Bioactivity of arid region honey: an in vitro study

Hilary, Serene; Habib, Hosam M.; Souka, Usama; Ibrahim, Wissam H.; Platat, Carine

doi:10.1186/s12906-017-1664-9

Cited by 28 publications

(19 citation statements)

References 37 publications

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“…Malondialdehyde (MDA), which is a lipid peroxidation product, was measured using the modified thiobarbituric acid reactive substances (TBARs) procedure [25]. Briefly, plasma samples were precipitated using 20% TCA and centrifuged at a high speed to retrieve the supernatant.…”

Section: Methodsmentioning

confidence: 99%

Urine Metabolites and Antioxidant Effect after Oral Intake of Date (Phoenix dactylifera L.) Seeds-Based Products (Powder, Bread and Extract) by Human

et al. 2019

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A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP, 360 g of 10% and 15% DSB, 30 mg and 60 mg/kg bodyweight DSE) was provided along with breakfast, with a two weeks wash-out period between 2 consecutive treatments. Blood was drawn at baseline, 1, 2, 8 and 24 h post intake. Urine was collected at baseline, 3, 8, and 24 h post intake. An abundant release of polyphenols was detected in urine within the 0–3 h post intake, reached a peak at 8 h, then decreased with polyphenols still being detected up to 24 h post intake. The antioxidant defence system, as measured by reduced glutathione (GSH), was strengthened as soon as 1 h and up to 8 h post intake. Markers of protein and lipid oxidative damages were reduced from 1 h and up to 8 and 24 h post intake, respectively. This supports an antioxidant effect of date seeds products in humans, most probably due to their polyphenols.

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Section: Methodsmentioning

confidence: 99%

Urine Metabolites and Antioxidant Effect after Oral Intake of Date (Phoenix dactylifera L.) Seeds-Based Products (Powder, Bread and Extract) by Human

et al. 2019

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“…Honey is a super saturated solution or semi-solid natural product synthesized from necter of flower by honey bees (Aljadi and Kamaruddin, 2004, Dashora et al, 2011, Hilary et al, 2017). Honey bees collect nectar, secretion of flowers or other living parts of plants and excretions of plant sucking insects.…”

Section: Introductionmentioning

confidence: 99%

Honey: Single food stuff comprises many drugs

Khan

Anjum

Rahman

et al. 2018

Saudi Journal of Biological Sciences

127

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Honey is a natural food item produced by honey bees. Ancient civilizations considered honey as a God gifted prestigious product. Therefore, a huge literature is available regarding honey importance in almost all religions. Physically, honey is a viscous and jelly material having no specific color. Chemically, honey is a complex blend of many organic and inorganic compounds such as sugars, proteins, organic acids, pigments, minerals, and many other elements. Honey use as a therapeutic agent is as old as human civilization itself. Prior to the appearance of present day drugs, honey was conventionally used for treating many diseases. At this instant, the modern research has proven the medicinal importance of honey. It has broad spectrum anti-biotic, anti-viral and anti-fungal activities. Honey prevents and kills microbes through different mechanism such as elevated pH and enzyme activities. Till now, no synthetic compound that works as anti-bacterial, anti-viral and anti-fungal drugs has been reported in honey yet it works against bacteria, viruses and fungi while no anti-protozoal activity has been reported. Potent anti-oxidant, anti-inflammatory and anti-cancerous activities of honey have been reported. Honey is not only significant as anti-inflammatory drug that relieve inflammation but also protect liver by degenerative effects of synthetic anti-inflammatory drugs. This article reviews physico-chemical properties, traditional use of honey as medicine and mechanism of action of honey in the light of modern scientific medicinal knowledge.

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“…8 So, they tend to react with other body chemicals and called reactive species (ROS oxygen -which are highly reactive). 34,35 The imbalance between oxidative stress and antioxidant scavengers leads to damage of important biomolecules in the cells, where lipids are biomolecules representing a significant target for ROS attack generating other reactive species such as MDA and can increase the risk of mutagenesis 36 and the body has a defense mechanism against its harmful effects through neutralizing the free radicals by means of either endogenous [e.g., glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CT)], 37 or exogenous from the diet e.g. flavonoids, 38 selenium, 39 vit.…”

Section: Resultsmentioning

confidence: 99%

“…54 Most of the antioxidant benefits of honey are associated with the presence of polyphenols since there is high correlation between honey's biological activity and the polyphenolic content. 36 Chrysin (5,7-dihydroxyflavone) is a dietary phytochemical abundantly present in many plant extracts, then in honey and propolis 45 which evolved as promising pharmacological agents as it possesses potent anti-inflammatory 63 and antioxidant properties 45,64 with direct positive effect on GPX, SOD and MDA. 64 Total serum globulins (Figure 4) increased significantly by the 1 st and the 4 th week respectively post intravenous infusion, while and ascorbic acid ( Figure 5) increased but not significantly.…”

Section: Resultsmentioning

confidence: 99%