Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

Sun, Peng; Zhao, Liang; Zhang, Nanhai; Zhou, Jingxuan; Zhang, Liebing; Wu, Wei; Ji, Baoping; Zhou, Feng

doi:10.3390/foods10112666

Cited by 24 publications

(16 citation statements)

References 240 publications

(202 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several dietary compounds could have cholesterol lowering effect. Such dietary compounds include oat/barley β-glucans [ 127 , 128 ], plant sterols/stanols [ 129 , 130 ], omega-3 fatty acids [ 131 , 132 ], polyphenols [ 133 , 134 ], and soy proteins [ 135 , 136 , 137 , 138 ]. In addition to cholesterol lowering effects, dietary molecules potentially have immunomodulatory effects.…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

“…Polyphenols are secondary metabolites containing one or more hydroxyl groups. Studies have shown that many polyphenols such as catechins, gallic acid, quercetin, chlorogenic acid, curcumin, and resveratrol, lower cholesterol levels in mice and in cultured cells in vitro [ 133 , 134 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

“…(iii) Berberine, curcumin, epigallocatechin gallate, resveratrol, and many others, increase the expression of hepatic LDL receptors by inhibiting the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), which is involved in cholesterol homeostasis [ 175 , 176 ]. (iv) Genistein inhibits the processing and the nuclear translocation of SREBP2, a regulator of cellular cholesterol synthesis, whereas epigallocatechin gallate, luteolin, and several other polyphenols, inhibit expression of SREBP2 ( Figure 2 ) [ 133 , 134 ]. (v) Quercetin, epigallocatechin gallate, naringin, and several others, increase the activity of CYP7A1, the rate-limiting enzyme that promotes cholesterol-to-bile acid conversion in the classical pathway of bile acids [ 177 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

“…(v) Quercetin, epigallocatechin gallate, naringin, and several others, increase the activity of CYP7A1, the rate-limiting enzyme that promotes cholesterol-to-bile acid conversion in the classical pathway of bile acids [ 177 ]. (vi) Anthocyanins reduce biliary cholesterol levels by increasing the expression of the ATP-binding cassette (ABC) transporters G5 (ABCG5), G8 (ABCG8), and decreasing the expression of ACAT2, in the liver and small intestine [ 133 , 134 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

“…Importantly, molecular mechanisms for the cholesterol lowering effect of polyphenols have been elucidated mainly in experimental systems. After ingestion, the presence of dietary polyphenols in the circulatory system rarely exceeds nanomolar concentrations in humans [ 133 , 178 ]. This inefficient absorption and low levels of circulation of polyphenols could explain the inconsistent lowering effects of polyphenols on blood cholesterols in clinical studies [ 179 , 180 , 181 ].…”

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

See 4 more Smart Citations

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Yanagisawa

Asai

et al. 2022

IJMS

View full text Add to dashboard Cite

Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized de novo. Cholesterol and oxysterols influence molecular and cellular events and subsequent biological responses of immune cells. The amount of dietary cholesterol influence on the levels of LDL cholesterol and blood oxysterols plays a significant role in the induction of pro-inflammatory state in immune cells, leading to inflammatory disorders, including cardiovascular disease. Cholesterol and oxysterols synthesized de novo in immune cells and stroma cells are involved in immune homeostasis, which may also be influenced by an excess intake of dietary cholesterol. Dietary compounds such as β-glucan, plant sterols/stanols, omega-3 lipids, polyphenols, and soy proteins, could lower blood cholesterol levels by interfering with cholesterol absorption and metabolism. Such dietary compounds also have potential to exert immune modulation through diverse mechanisms. This review addresses current knowledge about the impact of dietary-derived and de novo synthesized cholesterol and oxysterols on the immune system. Possible immunomodulatory mechanisms elicited by cholesterol-lowering dietary compounds are also discussed.

show abstract

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

Section: Cholesterol Lowering Dietary Compoundsmentioning

confidence: 99%

See 3 more Smart Citations

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Yanagisawa

Asai

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Alliaceae versus Brassicaceae for Dyslipidemia: State of the Art and Future Perspectives. Systematic Review and Meta‐Analysis of Clinical Studies

Piragine,

Malanima,

Ceccanti

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Dyslipidemia is a risk factor for cardiovascular diseases. Preclinical studies have shown that organosulfur compounds from the Alliaceae and Brassicaceae plants, such as garlic (Allium sativum L.) and broccoli (Brassica oleracea L.), have potential lipid‐lowering effects. However, their clinical efficacy is controversial, especially in “drug‐free” patients. The aim of this work was to summarize evidence on the lipid‐lowering properties of extracts containing organosulfur compounds in patients with dyslipidemia. Studies were searched in four databases (Medline, Scopus, Embase, and CENTRAL), from inception to October 11, 2023.Controlled clinical studies on patients with dyslipidemia receiving Alliaceae or Brassicaceae were included. The outcome was the change in lipid parameters from baseline. Random‐effect meta‐analysis of the extracted data was performed using R software. The effect size was expressed as mean difference (MD) and 95% confidence interval (CI). The certainty of evidence was assessed with the GRADE approach. Out of 28 studies that were reviewed, 22 were included in the meta‐analysis (publication period: 1981–2022). Results showed that Alliaceae extracts significantly reduce total cholesterol [MD: −15.2 mg/dL; 95% CI: −21.3; −9.1] and low‐density lipoprotein cholesterol levels [MD: −12.0 mg/dL; 95% CI: −18.1; −5.7], although with low certainty of evidence. Conversely, the lipid‐lowering properties of Brassicaceae extracts are still unexplored. Our results support the use of Alliaceae extracts in patients with hypercholesterolemia, but future high‐quality studies are needed. Our work suggests further exploration of the efficacy of Brassicaceae extracts, which may have high nutraceutical/phytotherapeutic potential, opening new perspectives in the management of dyslipidemia.

show abstract

A New Approach to Polycystic Ovary Syndrome and Related Cardio-metabolic Risk Factors: Dietary Polyphenols

Ulug,

Pinar

2023

Curr Nutr Rep

View full text Add to dashboard Cite

Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

Cited by 24 publications

References 240 publications

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System

Alliaceae versus Brassicaceae for Dyslipidemia: State of the Art and Future Perspectives. Systematic Review and Meta‐Analysis of Clinical Studies

A New Approach to Polycystic Ovary Syndrome and Related Cardio-metabolic Risk Factors: Dietary Polyphenols

Contact Info

Product

Resources

About