Bioactivity of Extractives from<i>Stachytarpheta urticaefolia</i>

Chowdhury, Rasheduzzaman; Rashid, Mamun Ur; Khan, Omar; Hasan, Choudhury M.

doi:10.1080/13880200490514203

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Stachytarpheta urticaefolia [43], several Phlomis spp. [40,44], Wiedemannia orientalis [45] and is also reportedly present in plants belonging to the Family Verbenaceae [45].…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

Agampodi

Katavic

Collet

et al. 2021

Preprint

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Wounds of various types continue to have a severe socioeconomic impact on the cost of health care. Globally, there has been increased interest surrounding the identification of bioactive compounds that promote or modulate the wound healing process. Stachytarpheta indica Linn. is traditionally used to heal wounds and relieve inflammation, however, the theorised pharmacological properties have not yet been scientifically validated. In this study, dried and ground plant leaves were extracted with water and methanol, which were then subjected to various analyses. Antimicrobial activity of the plant extracts and isolated compounds was determined using well diffusion assays, while the minimum inhibitory concentrations were determined with a colorimetric assay. Morphological changes of human keratinocytes in response to plant extracts were observed with differential interference contrast microscope imaging. Cell viability, proliferation and migratory effects post-treatment with the plant extracts were also evaluated via colorimetric cytotoxicity assays and a real-time cell analyser protocol. Anti-inflammatory effects of plant extracts and isolated compounds were evaluated by flow cytometry and cyclooxygenase and lipoxygenase enzyme inhibition assays. Three active compounds i.e. ipolamiide, verbascoside and iso-verbascoside, were isolated from S. indica leaves. Verbascoside demonstrated broad-range antibacterial activity and imposed strong inhibition at 9.77 μg/mL against Staphylococci spp. S. indica extracts (0.1-0.2 mg/mL) were shown to improve human keratinocyte proliferation up to 60 % and induce morphological changes by producing cytoplasmic projections at concentrations higher than 0.4 mg/mL. Plant extracts (6.25-100 μg/mL) and individual compounds (3.125-50 μg/mL) elicited strong anti-inflammatory effects by suppressing the expression of interleukin-8 and inhibiting cyclooxygenase-1 and 5-lipoxygenase enzymes. Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce inflammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds.

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“…Stachytarpheta urticaefolia [43], several Phlomis spp. [40,44], Wiedemannia orientalis [45] and is also reportedly present in plants belonging to the Family Verbenaceae [45].…”

Section: Discussionmentioning

confidence: 99%

“…Although there is no evidence of antibacterial activity, the anti-inflammatory effects of ipolamiide have been demonstrated in several studies [40,43,46]. Ipolamiide was isolated from S. indica by Tantisewie and Sticher [47] and Roengsumaran et al [48], although there was no indication of biological activities.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

Agampodi

Katavic

Collet

et al. 2021

Preprint

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Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

Sobhy,

AbouZid,

Kirollos

et al. 2024

Chemistry & Biodiversity

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There is an increasing interest in using iridoids and secoiridoids as major targets for chemical synthesis and biosynthesis. Iridoids can be found in numerous species of Lamiaceae, Verbenaceae, Scrophulariaceae, and other families. Iridoids possess a chemical structure characterized by a cyclopentane ring with oxidative substituents, forming a six‐membered ring. Various research groups have used these structures as valuable starting materials for regioselective and stereoselective synthesis. This approach has enormous potential for the production of bioactive alkaloids, prostaglandin analogues, and other bioactive natural compounds. Because there is currently no review on lamiide and ipolamiide, this review intends to pique researchers' interest in this vital topic of natural science for drug discovery from naturally occurring iridoids. Lamiide and ipolamiide have the potential to be useful tools in the pharmaceutical sector, enabling the use of these plant metabolites in a variety of medicinal compositions. Given that these molecules appear to be potential natural substances for treating human ailments, we get light on them as alternative therapeutic approaches using these compounds alone or in combination with other substances which will potentially lead to future (pre)‐clinical investigations.

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Antibacterial and Anti-inflammatory Activity of Extracts and Major Constituents Derived from Stachytarpheta indica Linn. Leaves and Their Potential Implications for Wound Healing

Agampodi

Katavic

Collet

et al. 2022

Appl Biochem Biotechnol

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Wounds of various types continue to have a severe socioeconomic impact on the cost of health care.Globally, there has been increased interest surrounding the identi cation of bioactive compounds that promote or modulate the wound healing process. Stachytarpheta indica Linn. is traditionally used to heal wounds and relieve in ammation, however, the theorised pharmacological properties have not yet been scienti cally validated. In this study, dried and ground plant leaves were extracted with water and methanol, which were then subjected to various analyses. Antimicrobial activity of the plant extracts and isolated compounds was determined using well diffusion assays, while the minimum inhibitory concentrations were determined with a colorimetric assay. Morphological changes of human keratinocytes in response to plant extracts were observed with differential interference contrast microscope imaging. Cell viability, proliferation and migratory effects post-treatment with the plant extracts were also evaluated via colorimetric cytotoxicity assays and a real-time cell analyser protocol.Anti-in ammatory effects of plant extracts and isolated compounds were evaluated by ow cytometry and cyclooxygenase and lipoxygenase enzyme inhibition assays. Three active compounds i.e. ipolamiide, verbascoside and iso-verbascoside, were isolated from S. indica leaves. Verbascoside demonstrated broad-range antibacterial activity and imposed strong inhibition at 9.77 μg/mL against Staphylococci spp. S. indica extracts (0.1-0.2 mg/mL) were shown to improve human keratinocyte proliferation up to 60 % and induce morphological changes by producing cytoplasmic projections at concentrations higher than 0.4 mg/mL. Plant extracts (6.25-100 μg/mL) and individual compounds (3.125-50 μg/mL) elicited strong anti-in ammatory effects by suppressing the expression of interleukin-8 and inhibiting cyclooxygenase-1 and 5-lipoxygenase enzymes. Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce in ammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds.

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Bioactivity of Extractives fromStachytarpheta urticaefolia

Cited by 5 publications

References 8 publications

Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

Antibacterial and Anti-inflammatory Activity of Extracts and Major Constituents Derived from Stachytarpheta indica Linn. Leaves and Their Potential Implications for Wound Healing

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