Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts

Tsiapara, Anna; Jaakkola, Mari; Chinou, İoanna; Graikou, Konstantia; Tolonen, Tiina; Virtanen, Vesa; Moutsatsou, Paraskevi

doi:10.1016/j.foodchem.2009.03.024

Cited by 114 publications

(105 citation statements)

References 29 publications

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“…Gallic acid can be used as a marker in differentiating these two honeydew honeys. The presence of quercetin and kaempferol has been reported in previous studies, in agreement with our own (Karabagias, Vavoura, Badeka, Kontakos, & Kontominas, 2014), together with absence of gallic acid (Tsiapara et al, 2009).…”

Section: Phenolic Profilessupporting

confidence: 93%

An investigation of Turkish honeys: Their physico-chemical properties, antioxidant capacities and phenolic profiles

et al. 2015

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Section: Phenolic Profilessupporting

confidence: 93%

An investigation of Turkish honeys: Their physico-chemical properties, antioxidant capacities and phenolic profiles

et al. 2015

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“…[3]. It has been used for centuries for its medical proprieties for anti-microbial, anti-viral, anti-parasitary, antiinflammatory, anti-oxidant, anti-mutagenic and anti-tumoral effects [4][5][6][7][8]. These medical proprieties principally depend on the plant composition.…”

Section: Open Accessmentioning

confidence: 99%

DNA Barcoding for Honey Biodiversity

2010

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Honey is produced by honeybees from nectar and from secretions of living plants. It reflects the honeybees’ diet and the local plant communities. Honey also shows different plant compositions in different geographical locations. We propose a new method for studying the plant diversity and the geographical origin of honey using a DNA barcoding approach that combines universal primers and massive parallel pyrosequencing. To test this method we use two commercial honeys, one from a regional origin and one composed of a worldwide mix of different honeys. We demonstrate that the method proposed here is fast, simple to implement, more robust than classical methods, and therefore suitable for analyzing plant diversity in honey

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“…[29] Greek honey extracts also inhibited cell viability on human prostate and endometrial cancer cells. [30]…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative and apoptotic effects of spanish honeys

Morales

Haza

2013

Phcog Mag

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Background:Current evidence supports that consumption of polyphenols has beneficial effects against numerous diseases mostly associated with their antioxidant activity. Honey is a good source of antioxidants since it contains a great variety of phenolic compounds.Objective:The main objective of this work was to investigate the antiproliferative and apoptotic effects of three crude commercial honeys of different floral origin (heather, rosemary and polyfloral honey) from Madrid Autonomic Community (Spain) as well as of an artificial honey in human peripheral blood promyelocytic leukemia cells (HL-60).Material and Methods:HL-60 cells were cultured in the presence of honeys at various concentrations for up to 72 hours and the percentage of cell viability was evaluated by MTT assay. Apoptotic cells were identified by chromatin condensation and flow cytometry analysis. ROS production was determined using 2´,7´-dichlorodihydrofluorescein diacetate (H2DCFDA).Results:The three types of crude commercial honey induced apoptosis in a concentration and time dependent-manner. In addition, honeys with the higher phenolic content, heather and polyfloral, were the most effective to induce apoptosis in HL-60 cells. However, honeys did not generate reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC) could not block honeys-induced apoptosis in HL-60 cells.Conclusion:These data support that honeys induced apoptosis in HL-60 cells through a ROS-independent cell death pathway. Moreover, our findings indicate that the antiproliferative and apoptotic effects of honey varied according to the floral origin and the phenolic content.

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Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts

Cited by 114 publications

References 29 publications

An investigation of Turkish honeys: Their physico-chemical properties, antioxidant capacities and phenolic profiles

An investigation of Turkish honeys: Their physico-chemical properties, antioxidant capacities and phenolic profiles

DNA Barcoding for Honey Biodiversity

Antiproliferative and apoptotic effects of spanish honeys

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