Bioactivity of Isoflavones: Assessment through a Theoretical Model as a Way to Obtain a “Theoretical Efficacy Related to Estradiol (TERE)”

Abstract

Abstract:The increase of human life span will have profound implications in Public Health in decades to come. By 2030, there will be an estimated 1.2 billion women in postmenopause. Hormone Replacement Therapy with synthetic hormones is still full of risks and according to the latest developments, should be used for the shortest time possible. Searching for alternative drugs is inevitable in this scenario and science must provide physicians with other substances that can be used to treat the same symptoms with less side effects. Systematic research carried out on this field of study is focusing now on isoflavones but the randomised controlled trials and reviews of meta-analysis concerning postmenopause therapy, that could have an important impact on human health, are very controversial. The aim of the present work was to establish a theoretical calculation suitable for use as a way to estimate the "Theoretical Efficacy (TE)" of a mixture with different bioactive compounds as a way to obtain a "Theoretical Efficacy Related to Estradiol (TERE)". The theoretical calculation that we propose in this paper integrates different knowledge about this subject and sets methodological boundaries that can be used to analyse already published data. The outcome should set some consensus for new clinical trials using isoflavones (isolated or included in mixtures) that will be evaluated to assess their therapeutically activity. This theoretical method for evaluation of a possible efficacy could probably also be applied to other herbal drug extracts when a synergistic or OPEN ACCESSInt. J. Mol. Sci. 2010, 11 481 contradictory bio-effect is not verified. In this way, it we may contribute to enlighten and to the development of new therapeutic approaches.

Possible Risks in Caucasians by Consumption of Isoflavones Extracts Based

“…Like that it is possible evaluate the theoretical impact of exposure to estrogen-like activity of isoflavones in various countries from all the data of different studies already published [44]. This theoretical calculation estimates the "Theoretical Efficacy (TE)" of a mixture with different bioactive compounds in a way to obtain a "Theoretical Efficacy Related to Estradiol (TERE)".…”

“…For this confusing data our previous proposition was, and still is, applying the calculation of "Theoretical Efficacy (of isoflavones) Related to Estradiol (TERE) [44]. Like that it is possible evaluate the theoretical impact of exposure to estrogen-like activity of isoflavones in various countries from all the data of different studies already published [44].…”

“…The form in which isoflavones are present in soybased foods and health supplements is important to assess the bioavailability of these products [36], Considering that genistein is, in a theoretical point of view [15,44], about 1000 times more active that daidzein the heath benefit and/or the toxicity could be different in two apparently identical products.…”

“…To do the theoretical calculation [44] the amounts of isoflavones were multiply for the "ERs binding affinities" based on the values obtained in literature [15]. After applying the proposed model, "Theoretical efficiency related to estradiol (TERE), for each mixture of isoflavones, the" Theoretical Efficiency (TE) was estimated which can be used to compare the potential bioactivity [44].…”

“…After applying the proposed model, "Theoretical efficiency related to estradiol (TERE), for each mixture of isoflavones, the" Theoretical Efficiency (TE) was estimated which can be used to compare the potential bioactivity [44].…”