Cabbage is an important leafy vegetable widely cultivated and consumed in Ghana. It offers a good source of vitamins and minerals to the human body. Despite its importance cabbage production is constrained by insect pests attack. Chemical control has being the main strategy, but without much success, thus the need for alternative options for pest management. Field experiments were conducted in the major and minor rainy seasons of 2014 to evaluate the insecticidal potential of Siam weed, Chromolaena odorata L. at three concentrations (10, 20 and 30 g/L w/v) in the management of the key pests of cabbage and its effect on their natural enemies. Neem seed extract (50 g/L) and Lambda cyhalothrin (Sunhalothrin ® 2.5 ml/L) were used as reference insecticides with tap water as a control. The key pests recorded during the major season were the cabbage aphid, Brevicoryne brassicae, and cabbage webworm, Hellula undalis, whiles Diamondback moths (DBM), Plutella xylostella and B. brassicae were recorded in the minor season. Generally, the three concentrations of C. odorata were efficacious in controlling aphids and DBM than the tap water and conventional insecticide, Sunhalothrin ® in both the minor and major seasons. However, the 10 and 20 g/L C. odorata recorded the highest buildup of natural enemy populations and also had higher yield as compared to 30 g/L C. odorata, Sunhalothrin ® , and tap water. The cabbage plots sprayed with neem obtained the highest yield and was the most economical to adopt, followed by the Chromolaena, and the least being the synthetic insecticide. Crude extracts from neem and C. odorata could become an integral part in the Integrated Pest Management of vegetables, especially in smallholder farms.