Bioactivity Screening of Antarctic Sponges Reveals Anticancer Activity and Potential Cell Death via Ferroptosis by Mycalols

Riccio, Gennaro; Nuzzo, Genoveffa; Zazo, Gianluca; Coppola, Daniela; Senese, Giuseppina; Romano, Lucia; Costantini, Maria; Ruocco, Nadia; Bertolino, Marco; Fontana, Angelo; Ianora, Adrianna; Verde, Cinzia; Giordano, Daniela; Lauritano, Chiara

doi:10.3390/md19080459

Cited by 18 publications

(12 citation statements)

References 54 publications

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“…The proliferation assay of human A549 and HepG2 tumor cell lines is adopted for screening anticancer drugs [27]. The A549 and HepG2 cell lines were obtained from the Affiliated Hospital of Guangdong Medical University.…”

Section: Methodsmentioning

confidence: 99%

Coding Recognition of the Dose-Effect Interdependence of Small Biomolecules Encrypted on Paired Chromatographic-Based Microassay Arrays

Deng

Lin

Cheng

2021

Preprint

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The discovery of new small molecular entities in diverse compounds suffers from the lack of a correlation recognition method between bioactivity and molecular characteristics such as DNA base pairing recognition in biomacromolecules. Here, by mapping a sample's 2D-HPTLC fingerprint into microplates with a grid size approximated to that of the chromatographic spots to create paired chromatographic-based microassay arrays, on which the microarray-based differentially expressed chromatographic spots are allowed to develop and assemble into a self-consistent array distribution gradient of multi-attributes of each chromatographic component's own, we propose a screening strategy to self-recognize small biomolecules. Specifically, on the paired chromatographic-based microassay arrays with the chromatographic matrix removed and the chromatographic distribution consistent, bioassays and bioguided LC-ESI-MS tracing are performed naturally, the expressed array distribution gradients of the bioactivity strength vs. the digital-specific quasimolecular ion intensity derived from the same chromatographic component are auto-collimated, and generated a pair of dose-effect interdependent 2D codes encrypted by the chromatographic fingerprint characteristics. Therefore, the recognition of molecules attributed to bioactivity in diverse compounds is transformed into a constraint satisfaction problem, which is addressed through examining the dose-effect interdependence of the 2D code pair by array matching algorithm. This approach represents the paradigm shift in small molecule drug screening from bioassay traversing molecular diversity library item-by-item to self-correlation recognition of each compound's own multiple attributes through its characteristic chromatographic behavior. This research strategy was successfully applied to galangal, and practiced the high-throughput digital preliminary screening of small biomolecules in a natural product.

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Section: Methodsmentioning

confidence: 99%

Coding Recognition of the Dose-Effect Interdependence of Small Biomolecules Encrypted on Paired Chromatographic-Based Microassay Arrays

Deng

Lin

Cheng

2021

Preprint

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“…A series of primary and secondary metabolites of marine organisms with potential applications for the prevention and treatment of different cancers have been reported to date [ 24 , 25 , 26 , 27 ]. Currently, there are 14 marine-derived drugs on the market, 9 of which are for cancer treatment.…”

Section: Why Marine Organisms and Which Are The Marine-derived Drugs ...mentioning

confidence: 99%

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Montuori

Hyde

Crea

et al. 2023

IJMS

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Prostate cancer is the most common cancer in men, with over 52,000 new cases diagnosed every year. Diagnostics and early treatment are potentially hindered by variations in screening protocols, still largely reliant on serum levels of acid phosphatase and prostate-specific antigen, with tumour diagnosis and grading relying on histopathological examination. Current treatment interventions vary in terms of efficacy, cost and severity of side effects, and relapse can be aggressive and resistant to the current standard of care. For these reasons, the scientific community is looking for new chemotherapeutic agents. This review reports compounds and extracts derived from marine organisms as a potential source of new drugs against prostate cancer. Whilst there are several marine-derived compounds against other cancers, such as multiple myeloma, leukemia, breast and lung cancer, already available in the market, the presently collated findings show how the marine environment can be considered to hold potential as a new drug source for prostate cancer, as well. This review presents information on compounds presently in clinical trials, as well as new compounds/extracts that may enter trials in the future. We summarise information regarding mechanisms of action and active concentrations.

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“…Mycalol can reduce the expression level of GPX4 and increase the expression of NCOA4 ( Table 3 ). Enhanced NCOA4 expression induces ferroptosis, which may be directly related to the inhibition of liver cancer cell growth by mycalol ( Riccio et al, 2021 ). Solasonine, a compound isolated from Solanum melongena, has anti-infective and neurogenesis-promoting effects.…”

Section: Current Stage Of Pharmacological Study Of Ferroptosis In Hep...mentioning

confidence: 99%

Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma

Wang

et al. 2022

Front. Mol. Biosci.

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Ferroptosis is a novel process of regulated cell death discovered in recent years, mainly caused by intracellular lipid peroxidation. It is morphologically manifested as shrinking of mitochondria, swelling of cytoplasm and organelles, rupture of plasma membrane, and formation of double-membrane vesicles. Work done in the past 5 years indicates that induction of ferroptosis is a promising strategy in the treatment of hepatocellular carcinoma (HCC). System xc-/GSH/GPX4, iron metabolism, p53 and lipid peroxidation pathways are the main focus areas in ferroptosis research. In this paper, we analyze the ferroptosis-inducing drugs and experimental agents that have been used in the last 5 years in the treatment of HCC. We summarize four different key molecular mechanisms that induce ferroptosis, i.e., system xc-/GSH/GPX4, iron metabolism, p53 and lipid peroxidation. Finally, we outline the prognostic analysis associated with ferroptosis in HCC. The findings summarized suggest that ferroptosis induction can serve as a promising new therapeutic approach for HCC and can provide a basis for clinical diagnosis and prevention of this disease.

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Bioactivity Screening of Antarctic Sponges Reveals Anticancer Activity and Potential Cell Death via Ferroptosis by Mycalols

Cited by 18 publications

References 54 publications

Coding Recognition of the Dose-Effect Interdependence of Small Biomolecules Encrypted on Paired Chromatographic-Based Microassay Arrays

Coding Recognition of the Dose-Effect Interdependence of Small Biomolecules Encrypted on Paired Chromatographic-Based Microassay Arrays

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma

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