Bioactivity studies of two copper complexes based on pyridinedicarboxylic acid N-oxide and 2,2′-bipyridine

A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury

“…It is worth noting that pyridine nitrogen oxides have been proven effective as reducing agents for scavenging ROS. 25,26 Initially, MOCs constructed directly from ligands containing pyridine nitrogen oxide moieties were considered. However, our attempts to obtain the desired MOC using the related ligand were unsuccessful.…”

On the importance of π-stacking interactions in the complexes of copper and zinc bearing pyridine-2,6-dicarboxylic acid N-oxide and N-donor auxiliary ligands

“…8 Among O-donor ligands, pyridine-based carboxylate ligands are responsible for creating thousands of compounds known not only for their structural diversity but also for their wide variety of applications in many fields from catalysts, 9,10 luminescence, 11,12 gas adsorption 13,14 to their antiproliferative activities. 15,16 For several years, pyridine-2,6dicarboxylic acid (H 2 pydco) has received considerable attention due to the symmetric position of its carboxylate groups on each side of the pyridine ring which can form 5-membered chelate rings or bridge with neighboring metal centres. Up to now, numerous metal-organic complexes, cocrystals, and salts based on this ligand have been reported.…”

“…20,23 In the recent past, transition metal complexes have been synthesized using H 2 pydco as primary ligand and bpy or other bridging N-donor as auxiliary ligands. 15,16 However, according to the CSD survey, examples containing phen and pz as auxiliary ligands have not yet been reported. Here, we report the synthesis and crystal description of three coordination complexes containing H 2 pydco ligand which are formulated as {[Cu(pydco)(pz) 0.5 (…”

Coordination complexes of zinc and manganese based on pyridine-2,5-dicarboxylic acid N-oxide: DFT studies and antiproliferative activities consideration

“… 12,22,23 It is important to note that N -oxidation of the pyridine ring in the H 2 pydc can produce an O -donor ligand (pyridine-2,5-dicarboxylic acid N -oxide (H 2 pydco)) with better electron donor affinity than the nitrogen atom of the pyridine ring in H 2 pydc because the neutral nitrogen atom can donate one pair of electrons, while the charge-polarized pyridine- N -oxide moiety can donate three pairs of electrons. 24 According to the literature survey, this feature can enhance the CO 2 separation properties of isoreticular MOFs. 11 Several reviews reflect the huge potential of metal-based frameworks as drug delivery and cancer theragnostic platforms.…”