Bioadhesion design of hydrogels: adhesion strategies and evaluation methods for biological interfaces

Wang, Huanhui; Li, Xuena; Li, Maocheng; Wang, Shuangqing; Zuo, Along; Jian-peng, Guo

doi:10.1080/01694243.2021.2020502

Cited by 4 publications

(5 citation statements)

References 151 publications

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“…On the other hand, a rough interface, in accordance with mechanical theory, increases the surface area that can make contact as well as the viscoelastic and plastic energy dissipation during joint breakage (Figure 3d) [35]. The first bonding hypothesis, known as me- [36] with permission.…”

Section: Adhesion Properties 221 Four Theories Of Bio-adhesionmentioning

confidence: 60%

“…The findings demonstrated that the interstitial liquid's contact geometry, and capillary density are strongly connected to the wet adhesion, and the ratio of capillary and adhesive forces is key to elucidating the mechanism of wet adhesion. [36] with permission.…”

Section: Adhesion Properties 221 Four Theories Of Bio-adhesionmentioning

confidence: 99%

“…The chitosan chains diffuse into the gel at pH = 7, using hydrogen bonds to form a new network. Figures modified from[36] with permission.…”

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confidence: 99%

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Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Han

Wang

2022

Gels

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Currently, uncontrolled bleeding remains a serious problem in emergency, surgical and battlefield environments. Despite the specific properties of available hemostatic agents, sealants, and adhesives, effective hemostasis under wet and dynamic conditions remains a challenge. In recent years, polymeric hydrogels with excellent hemostatic properties have received much attention because of their adjustable mechanical properties, high porosity, and biocompatibility. In this review, to investigate the role of hydrogels in hemostasis, the mechanisms of hydrogel hemostasis and adhesion are firstly elucidated, the adhesion design strategies of hemostatic hydrogels in wet environments are briefly introduced, and then, based on a comprehensive literature review, the studies and in vivo applications of wet-adhesive hemostatic hydrogels in different environments are summarized, and the improvement directions of such hydrogels in future studies are proposed.

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Section: Adhesion Properties 221 Four Theories Of Bio-adhesionmentioning

confidence: 60%

Section: Adhesion Properties 221 Four Theories Of Bio-adhesionmentioning

confidence: 99%

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Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Han

Wang

2022

Gels

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“…18,19 Nonetheless, low-adhesive hydrogel scaffolds often lack the biological activity inherent in natural matrices, thereby leading to a diminished long-term cell survival rate. 20 In addition to low-adhesive polymers, chitosan has been found to improve the calcium binding capacity of the substrate and up-regulate the N-cadherin adhesion molecule, facilitating stem cells into spheroids. 21,22 Moreover, it is remarkable that the cellular spheroids on chitosan-based scaffolds exhibited long-term proliferation and high chondrogenic differentiation efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 Nonetheless, low-adhesive hydrogel scaffolds often lack the biological activity inherent in natural matrices, thereby leading to a diminished long-term cell survival rate. 20…”

Section: Introductionmentioning

confidence: 99%

Bioprinted biomimetic hydrogel matrices guiding stem cell aggregates for enhanced chondrogenesis and cartilage regeneration

Liu,

Du,

Zhang

et al. 2024

J. Mater. Chem. B

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Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management

Jafari,

Al‐Ostaz,

Nouranian

2024

Polymers for Advanced Techs

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Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development and multifunctional nature of these bioadhesives, particularly emphasizing their role in enhancing adhesion performance in wet environments and optimizing mechanical properties for use in dynamic tissues. Key areas covered include the chemical and physical mechanisms of adhesion, the incorporation of multi‐adhesion strategies that combine covalent and non‐covalent bonding, and bioinspired designs mimicking natural adhesives such as those of barnacles and mussels. Additionally, the review discusses emerging applications of bioadhesives in the regeneration of musculoskeletal, cardiac, neural, and ocular tissues, highlighting the potential for bioadhesive‐based therapies in complex biological settings. Despite substantial progress, challenges such as scaling lab‐based innovations for clinical use and overcoming environmental and mechanical constraints remain critical. Ongoing research in bioadhesive technologies aims to bridge these gaps, promising significant improvements in medical adhesives tailored for diverse therapeutic needs.

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Bioadhesion design of hydrogels: adhesion strategies and evaluation methods for biological interfaces

Cited by 4 publications

References 151 publications

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Bioprinted biomimetic hydrogel matrices guiding stem cell aggregates for enhanced chondrogenesis and cartilage regeneration

Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management

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