Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix

Chan, Vincent; Liu, Kuo-Kang; Visage, Catherine Le; Ju, Bin-Feng; Leong, Kam W.

doi:10.1016/j.biomaterials.2003.11.021

Cited by 11 publications

(12 citation statements)

References 19 publications

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“…A critical factor that contributed to the success of this particle-mediated treatment was that the particles preferentially adsorbed to the mucosa lining the bladder wall. This preferential adhesion was attributed to the negative zeta potential resulting from partially hydrolyzed polymer side chains, or to the acidic pH, which may change the surface charges of the particles, allowing hydrophobic and ionic interactions with mucous (7,8). Residual poly(vinylalcohol) (PVA) on the particle was also reported to play a role in adhesion to the mucosa of the gastrointestinal tract (9).…”

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confidence: 99%

MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery

Chen

Visage

Qiu

et al. 2005

Magnetic Resonance in Med

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Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was encapsulated into biodegradable, bioadhesive polymeric microparticles to enable noninvasive monitoring of their local intravesical delivery with MRI. The microparticles were characterized by contrast agent encapsulation and release kinetics, T 1 relaxation rates, and contrast enhancement in vivo. The level of Gd-DTPA loading into microparticles was 14.3 ؎ 0.6 g/mg polymer. The measured T 1 relaxation rates of the microparticles showed a direct dependence on Gd-DPTA content. Both 1.5T and 4.7T MR scanners were used to image murine bladders instilled intravesically with Gd-DTPA-loaded particles in vivo. MR images showed ring-shaped regions of enhancement inscribing the bladder wall, which were attributed to the microparticles that were preferentially adherent to the mucosa lining the urothelium. The images of controls exhibited no such enhancement. The normalized signal intensities measured from post-instillation images were significantly greater (P < 0.05) than those in the pre-instillation images. Contrast enhancement was observed for at least 5 days after the initial instillation, although the enhancement decreased due to microparticle degradation or mucosa renewal. The localized distribution of biodegradable, bioadhesive microparticles encapsulating Gd-DTPA was successfully visualized with MRI in vivo, allowing particle-mediated delivery to be temporally and spatially monitored noninvasively. Magn Reson Med 53:614 -620, 2005.

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confidence: 99%

MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery

Chen

Visage

Qiu

et al. 2005

Magnetic Resonance in Med

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“…Chemical Stability of OB Solution After complete dissolution in methanol, OB was introduced into phosphate buffers of various pH (pHϭ1, 3,6,8,10,11,12), and OB concentration was fixed at 0.1 mg/ml. Sample solutions were then incubated in a water bath at 60°C, and the remaining OB was determined by HPLC.…”

Section: Methodsmentioning

confidence: 99%

“…In the urological field, the application of bioadhesive polymers such as chitosan, polycarbophil, 8,9) poly(methylidene, alonate 2.12) 10) and hydroxypropylcellulose (HPC) have been reported. 11,12) With regard to the OB intravesical instillation, Chiba et al demonstrated that addition of 1.0% HPC effective prolongs OB retention in the bladder.…”

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confidence: 99%

Formulation Study of Intravesical Oxybutynin Instillation Solution with Enhanced Retention in Bladder

Hanawa

Tsuchiya

Endo

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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A formulation study of intravesical oxybutynin (OB) preparations was carried out in order to improve the effectiveness in intravesical instillation therapy for spastic neurogenetic bladder. Sodium hyaluronate (HYA) was introduced to enhance the muco-adhesiveness of the instillation preparation, and the physicochemical properties of the OB formulation were evaluated in comparison with a conventional formulation containing hydroxypropylcellulose (HPC). The viscous properties and in vitro adhesiveness increased with the amount of the polymeric additives, and retention properties of OB in rabbit bladder were comparable after addition of 0.4% HYA and 1.0% HPC. HYA was able to enhance the intravesical retention properties of OB instillation solution to a lesser degree than HPC, it seemed to be a useful additive in the OB instillation due to its safety and mucosal-protective effect.

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“…125,126 Scleral disks were manufactured by a compression-molding method using a new synthetic polymer, poly(methylidenemalonate) (PMM2.1.2), as the matrix (Fig. 12).…”

Section: A Scleral Discoid Devicementioning

confidence: 99%

A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

Choonara

Pillay

Danckwerts

et al. 2010

Journal of Pharmaceutical Sciences

120

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Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix

Cited by 11 publications

References 19 publications

MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery

MR imaging of biodegradable polymeric microparticles: A potential method of monitoring local drug delivery

Formulation Study of Intravesical Oxybutynin Instillation Solution with Enhanced Retention in Bladder

A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

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