Bioadhesive Films for Drug Delivery Systems

Huanbutta, Kampanart; Sangnim, Tanikan

doi:10.1002/9781119640240.ch4

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Elemen kunci dari sistem untuk desain dari polimer mukoadhesif yaitu kemampuan untuk melekat pada lapisan mukosa [1][2][3] . Sistem penghantaran obat melalui rute mukosa oral tidak melewati first pass effect metabolism dan zat aktif tidak melewati cairan asam lambung sehingga terhindar dari kondisi yang ekstrem 4 .…”

Section: Pendahuluanunclassified

Optimasi Formula Basis Sediaan Edible Film dengan Kombinasi Polimer Carbomer 940 dan Kappa Karagenan

2020

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Salah satu bentuk sediaan mukoadhesif adalah edible film. Bentuk ini dapat meningkatkan waktu tinggal pada mukosa dibandingkan dengan gel oral. Pada penghantaran lokal untuk penyakit mulut seperti sariawan, edible film membantu melindungi luka permukaan sehingga rasa sakit dapat berkurang serta pengobatan lebih efektif. Tujuan penelitian ini adalah optimasi formula basis sediaan edible film menggunakan kombinasi Carbomer 940 dan kappa karagenan dengan merancang beberapa formula secara bertahap sampai didapatkan komposisi formula yang baik. Metode pembuatan sediaan edible film yang digunakan dalam penelitian ini adalah solvent casting yang evaluasinya berupa kemampuan formula membentuk lembaran sediaan edible film yang kering, tidak lengket dan tidak mudah sobek. Hasil optimasi menunjukkan bahwa basis sediaan edible film menggunakan kombinasi Carbomer 940 dan kappa karagenan menghasilkan sediaan edible film yang baik yaitu formula dengan konsentrasi karagenan sebesar 1,5% dan Carbomer 940 antara 0,1-0,5%. Berdasarkan hal tersebut dapat disimpulkan bahwa formula dengan kombinasi Carbomer 940 1,5% dan kappa karagenan 0,1-0,5% dapat digunakan sebagai basis sediaan edible film.Kata kunci: Mukoadhesif, Edible Film, Polimer, Carbomer, Kappa karagenan

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Section: Pendahuluanunclassified

Optimasi Formula Basis Sediaan Edible Film dengan Kombinasi Polimer Carbomer 940 dan Kappa Karagenan

2020

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“…The most common solvent evaporation method was used for the formulation of films; in this technique, all the ingredients, including the active drug, plasticizer, and polymer, are solubilized in water to make a solution. Then the ready solution was transferred to Petri dishes of the required size and allowed to cool or evaporate the water content [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study

Safhi,

Siddique,

Zaman

et al. 2023

Pharmaceuticals

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A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride (ITHC) to improve their bioavailability and, hence, improve compliance with the patients of migraines and its associated symptoms. The prepared films were evaluated for various in vitro parameters, including surface morphology, mechanical strength, disintegration test (DT), total dissolving time (TDT), drug release and drug permeation, etc., and in vivo pharmacokinetic parameters, such as area under curve (AUC), mean residence time (MRT), half-life (t1/2), time to reach maximum concentration (Tmax), and time to reach maximum concentration (Cmax). The outcomes have indicated the successful preparation of the films, as SEM has confirmed the smooth surface and uniform distribution of drugs throughout the polymer matrix. The films were found to be mechanically stable as indicated by folding endurance studies. Furthermore, the optimized formulations showed a DT of 13 ± 1 s and TDT of 42.6 ± 0.75 s, indicating prompt disintegration as well as the dissolution of the films. Albino rabbits were used for in vivo pharmacokinetics, and the outcomes were evident of improved pharmacokinetics. The drug was found to rapidly permeate across the buccal mucosa, leading to increased bioavailability of the drug: Cmax of 130 and 119 ng/mL of ITHC and EHBR, respectively, as compared to 96 (ITHC) and 90 ng/mL (EHBR) of oral solution. The conclusion can be drawn that possible reasons for the enhanced bioavailability could be the increased surface area in the form of buccal films, its rapid disintegration, and faster dissolution, which led toward the rapid absorption of the drug into the blood stream.

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