Bioadhesives with Antimicrobial Properties

Abstract

Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling on a variety of medical conditions. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents or inherently antimicrobial polymers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, we discuss the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties. In particular, we will summarize different methods for their synthesis and will review their experimental and clinical applications on a variety of organs. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive medical outcomes.This article is protected by copyright. All rights reserved

Hemostatic and Ultrasound-Controlled Bactericidal Silk Fibroin Hydrogel via Integrating a Perfluorocarbon Nanoemulsion

“…This enhancement may be attributed to ultrasonic cavitation sensitization by the perfluorocarbons. Meanwhile, the typical energetic free radical 1 O 2 , generated by PpIX, was observed only in the SP + US group, further validating the effectiveness of the sonodynamic ROS generation. Moreover, as depicted in Figure S6, via examination from near-infrared thermal imaging, the temperature of diverse concentrations of SF/SP hydrogels did not transcend 7 °C from ambient temperature.…”

“…Excessive blood loss and infections are the substantial contributors to mortality and disability in surgical or traumatic wounds. 1 In civilian settings, hemorrhage accounts for approximately 30% of prehospital deaths, while sepsis contributes to about 10%. According to the U.S. Army's Tactical Combat Casualty Care (TCCC) project, 24% of prehospital deaths on the battlefield are "reversible", among which 90.9% are caused by blood loss.…”

“…Excessive blood loss and infections are the substantial contributors to mortality and disability in surgical or traumatic wounds . In civilian settings, hemorrhage accounts for approximately 30% of prehospital deaths, while sepsis contributes to about 10%.…”

Natural polyphenolic antibacterial bio-adhesives for infected wound healing

“…Noting that the pig skin exhibited strong adhesion performances (∼300 kPa), which met the requirements of bio-tissues according to previous reports in the literature. 19,46–48 So, the excellent tissue adhesion performance of the MTA natural bioadhesives was further verified by using a tissue cutting repair process. In brief, various tissues including heart, liver, spleen, stomach, and kidney were made into a 5 mm wound using scissors, and the MTA natural bio-adhesives were applied onto the wound surface to achieve adhesion.…”

“…12–15 Bio-adhesives, as new medical adhesives, which are effective candidates to replace sutures, have the advantages of effective treatment of wounds, good biocompatibility, and provide a suitable environment for cell growth and tissue repair. 16–19 Therefore, it is important and effective to construct a new multifunctional bio-adhesive wound dressing for infected wounds.…”