Bioartificial Liver Inoculated with Porcine Hepatocyte Spheroids for Treatment of Canine Acute Liver Failure Model

Chen, Zhong; Ding, Yitao; Xu, Qi; Yu, Decai

doi:10.1046/j.1525-1594.2003.07140.x

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Hepatocyte transplantation may also be able to replace whole‐organ transplantation in the treatment of certain metabolic liver diseases (19). Many sources of hepatic cells have been proposed and investigated as an alternative to isolated human hepatocytes, such as human‐derived tumoral cell lines (20), immortalized human hepatocytes, (21, 22) porcine liver cells (23–25), etc. Each of these sources presents problems and relative contraindications to their clinical use including the risk of neoplastic transmission or transformation and biosafety for animal tissue.…”

Section: Discussionmentioning

confidence: 99%

In vitroanalysis of cryopreserved alginate-poly-l-lysine-alginate-microencapsulated human hepatocytes

Hang

Shi

et al. 2010

Liver International

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Section: Discussionmentioning

confidence: 99%

In vitroanalysis of cryopreserved alginate-poly-l-lysine-alginate-microencapsulated human hepatocytes

Hang

Shi

et al. 2010

Liver International

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“…Many BAL systems have been tested, such as ELAD (Extracorporeal Liver Assist Devices) [183], BLSS (bioartificial liver support system) [184], and BIOLIV A3A [185]. Although considerable improvements have been made, BAL systems are still in early stages of development with countless challenges.…”

Section: Artificial Livermentioning

confidence: 99%

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

Nguyen

Thi

et al. 2021

Membranes

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The recent outbreak of the COVID-19 pandemic in 2020 reasserted the necessity of artificial lung membrane technology to treat patients with acute lung failure. In addition, the aging world population inevitably leads to higher demand for better artificial organ (AO) devices. Membrane technology is the central component in many of the AO devices including lung, kidney, liver and pancreas. Although AO technology has improved significantly in the past few decades, the quality of life of organ failure patients is still poor and the technology must be improved further. Most of the current AO literature focuses on the treatment and the clinical use of AO, while the research on the membrane development aspect of AO is relatively scarce. One of the speculated reasons is the wide interdisciplinary spectrum of AO technology, ranging from biotechnology to polymer chemistry and process engineering. In this review, in order to facilitate the membrane aspects of the AO research, the roles of membrane technology in the AO devices, along with the current challenges, are summarized. This review shows that there is a clear need for better membranes in terms of biocompatibility, permselectivity, module design, and process configuration.

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“…By applying capillary membrane technology that gives a dynamic and continuous perfusion, a physical active scaffold for cell aggregation is provided. The medium perfusion with the cells floating in the space between capillaries offer a system allowing the cells to grow with increased cell density closer to physiological levels (Chen et al, 2003). The hollow fiber reactors have been further developed to a special four‐compartment bioreactor developed by Gerlach et al (1994) and Zeilinger et al (2002), a highly sophisticated device for culturing of hepatocytes (Fig.…”

Section: Differentiation Of Hesc Into Functional Cell Typesmentioning

confidence: 99%

Elastofibroma: Cytomorphologic, histologic, and radiologic findings in five cases

Vincent

Maleki

2011

Diagnostic Cytopathology

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Elastofibroma is a rare benign, solid, ill-defined and slow-growing soft tissue lesion that typically arises between the tip of scapula and chest wall of elderly. Fine needle aspiration (FNA) is a commonly used technique to definitively diagnose the condition. However, the collagenous nature of the mass often results in a paucicellular FNA smear, resulting in a false-negative report. Herein, we report cytomorphologic, histological, and radiologic findings in five cases. Five cases of elastofibroma were retrospectively retrieved from the cytopathology archives of a teaching hospital. The cytological material was obtained by CT-guided (n = 2) and ultrasound-guided (n = 3) FNA. Smears were stained with Diff-Quik and Papanicolaou stains. Elastic stain and mucicarmine were reviewed in one case. Radiologic images and medical records and histology of all cases were reviewed. There were four patients (two men and two women). Their ages ranged from 64 to 84 (mean = 71.25 years). All tumors were subscapular (n = 2 right side, n = 1 left side, and one bilateral). Tumor sizes ranged from 3.3 to 7.5 cm in greatest dimension. Aspirated material was hypocellular in all cases, consisting of scattered uniform spindle cells, mature adipocytes, and collagen. Petaloid globules and serrated and braid-like linear elastic fibers were haphazardly scattered. The characteristic petaloid globules typical of elastofibroma in aspirated material can be inadvertently mistaken or overlooked sincethe samples are hypocellular. Awareness of cytomorphologic features of elastofibroma and the typical clinical setting will permit an accurate diagnosis and eliminate the need for preoperative biopsy.

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Bioartificial Liver Inoculated with Porcine Hepatocyte Spheroids for Treatment of Canine Acute Liver Failure Model

Cited by 12 publications

References 45 publications

In vitroanalysis of cryopreserved alginate-poly-l-lysine-alginate-microencapsulated human hepatocytes

In vitroanalysis of cryopreserved alginate-poly-l-lysine-alginate-microencapsulated human hepatocytes

The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives

Elastofibroma: Cytomorphologic, histologic, and radiologic findings in five cases

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