Bioassay Applications of Aptamer-Functionalized Rare Earth Nanomaterials

Abstract

The levels of some biomolecules and ions in the body are usually related to the structural and functional changes of cells, tissues, organs, etc., which directly affect the prevention, diagnosis, and treatment of diseases. Therefore, in vivo bioassays of these substances are of great significance in medical and healthcare fields. The nano fluorescent probes consisted of rare earth nano materials have advantages of high sensitivity, simplicity, efficiency, and strong anti-interference ability, thus showing great potential in bioassays. The functionalization of aptamers on rare earth nanomaterials can further provide better specific recognition ability and biocompatibility for nano fluorescent probes, thereby enhancing their bioassays ability in complex samples. In this paper, the research progress of aptamer-functionalized rare earth nanomaterials as nano fluorescent probes in the field of bioassays is reviewed, and the main types, properties, detection mechanisms and detection substances are briefly introduced.

Experimental study on synchrotron radiation photoionization of secondary organic aerosol derived from styrene ozonolysis

“…Based on the above UV–Vis and IR spectra and the possible reaction mechanism between styrene and ozone, it can be confirmed that formaldehyde, formic acid, benzene, phenol, benzaldehyde, and benzoic acid are the main constituents of styrene SOA particles. This is consistent with the product information detected in the styrene ozonolysis experiments conducted by Chiappini et al, [ 9 ] Jia et al, [ 11 ] and Na et al [ 12 ] Compared with the previous styrene chamber experiments, [ 8–12 ] VUV‐PIMS is used to on‐line characterize the components of SOA particles in this study. By controlling the photon flux, VUV‐PIMS on‐line measurement technology based on synchrotron radiation photoionization can minimize the possibility of dissociation of tested organic molecules, reduce the generation of fragment ions, and obtain the molecular ion peak of the component.…”

“…In the infrared spectrum, 3,667 and 1,657 cm −1 correspond to the stretching vibration peaks of OH and CO, which can confirm the existence of carboxylic acids in extraction solutions. Also, peak at 1,249 cm −1 is the stretching vibration peak of CO in phenolic substances, [ 11,64 ] which further authenticates that the major constituents of styrene SOA particles are phenolic and carbonyl compounds.…”

“…[6,7] In addition, styrene mainly undergoes reactions with ozone and other oxidants in the atmosphere to form secondary organic aerosol (SOA). [8][9][10][11][12] SOA particles can absorb and scatter sunlight, reduce atmospheric visibility, [13,14] penetrate deep into the lungs and bronchus, and endanger human health. [15] The C C group and benzene ring make styrene, which has both alkene and aromatic properties and has strong reactivity.…”

“…Smog chamber system is commonly used to simulate the atmospheric ozonation [8][9][10][11][12] and photooxidation [17,18] reaction process of styrene. SOA particles are collected by filter membranes or impactors.…”

A Europium–Organic Framework Sensing Material for 2-Aminoacetophenone, a Bacterial Biomarker in Water

“…Lanthanide metal–organic frameworks (Ln-MOFs) constructed by lanthanide nodes and organic linkers via coordination bonds are promising sensing materials for not only their permanent porosities and structural tunabilities , but also excellent photoluminescence based on an “antenna effect” − with rapid and efficient sensing performance because the photoluminescence of Ln-MOFs can be fine-tuned by the host–guest interaction through rational structure and energy-level matching. − To date, well-designed luminescent Ln-MOFs have successfully been studied for the detection of gases, cations, anions, volatile organic compounds and persistent organic pollutants, , chiral molecules, biomakers, biomolecules, and so on. However, to the best of our knowledge, the application of Ln-MOFs for the detection of PA or its biomarker has not been reported.…”