Bioassay-guided isolation and
            <i>in silico</i>
            study of antihyperlipidemic compounds from
            <i>Onosma hispidum</i>
            Wall

Saleem, Bushra; Islam, Muhammad; Ahmed, Abrar; Saeed, Hamid; Imtiaz, Fariha; Muzaffar, Sana

doi:10.1080/07391102.2023.2242503

Cited by 1 publication

(1 citation statement)

References 54 publications

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“…Thymidine (13) is also isolated from Hydrilla verticillata [20], and the structural analog of 13, azidothymidine (AZT), is commonly used to treat HIV infection [37]. 1,2-Benzenedicarboxylic acid bis(2-methyl heptyl) ester ( 16) is obtained from Phellinus linteus, and previous in silico and in vitro results have validated that 16 could be exploited as a promising pancreatic lipase inhibitor [38]. β-Sitosterol (17) has been reported to be present in different parts of plants, such as fruits, leaves [39], and rhizomes [40], and possesses anti-inflammatory and immunomodulatory activities [41].…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites from the Nematode-Trapping Fungus Dactylellina haptotyla YMF1.03409

Lei,

Zhang,

Zhao

et al. 2023

Microorganisms

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As a representative nematode-trapping fungus, Dactylellina haptotyla can capture and kill nematodes by producing traps, known as adhesive knobs. In this paper, the strain of D. haptotyla YMF1.03409 was studied by means of medium screening, fermentation, and purification and identification of crude extracts. Eighteen compounds were obtained from D. haptotyla YMF1.03409, including two new metabolites, nosporins C (1) and D (2). The known metabolites were identified to be 3-chloro-4-methoxybenzaldehyde (3), 3-chloro-4-methoxybenzoic acid (4), 2-chloro-1-methoxy-4-(methoxymethyl)benzene (5), 3-hydroxy-3-methyloxindole (6), nicotinic acid (7), succinic acid (8), 3,4-dihydroxybutanoic acid (9), 5′-O-methyladenosine (10), uridine (11), 2′-deoxyuridine (12), thymidine (13), 3-(phenylmethyl)-2,5-morpholinedione (14), methyl-β-D-glucopyranoside (15), 1,2-benzenedicarboxylic acid bis(2-methyl heptyl) ester (16), β-sitosterol (17), and 3β,6α-diol-stigmastane (18). The bioactive assay showed that these compounds had no obvious nematicidal activity against the nematodes Meloidogyne incognita and Panagrellus redivivus.

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Section: Discussionmentioning

confidence: 99%