Bioavailability and absorption analysis of oxytetracycline orally administered to the standardized moulting farmed Pacific white shrimps (Penaeus vannamei)

Faroongsarng, Damrongsak; Chandumpai, Ausa; Chiayvareesajja, Sommai; Theapparat, Yongyuth

doi:10.1016/j.aquaculture.2007.04.019

Cited by 25 publications

(21 citation statements)

References 15 publications

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“…In P. vannamei, the target species in this study, Chiayvareesajja et al (2006) have demonstrated both a two-and three-compartment models for OTC levels in hemolymph after intra-sinus dosing and made use of a two-compartment model for simplicity. On the other hand, Faroongsarng et al (2007) argued that OTC pharmacokinetics in shrimp may be modeled as a three-compartment system, including central (hemolymph), digestive (hepatopancreas) and peripheral compartments, rather than two. However, Gómez-Jimenez et al (2008) suggested that the hepatopancreas may be an important peripheral tissue in P. vannamei that accumulates OTC regardless of two-compartment or three-compartment models proposed for pharmacokinetics studies.…”

Section: Discussionmentioning

confidence: 98%

“…It has potential for use in farm-raised shrimp for the treatment of vibriosis like Vibrio alginolyticus and Vibrio harveyi. There are many studies on the pharmacokinetics and residues of OTC in marine and freshwater shrimp (Mohney et al 1997;Bermúdez-Almada et al 1999;Brillantes et al 2001;Uno 2002Uno , 2004Sangrungruang et al 2004;Reed et al 2004Reed et al , 2006Weifen et al 2004;Uno et al 2006;Poapolathep et al 2008a, b), but limited information of OTC dispositions in P. vannamei is available (Chiayvareesajja et al 2006;Nogueira-Lima et al 2006;Faroongsarng et al 2007;Gómez-Jimenez et al 2008). …”

Section: Introductionmentioning

confidence: 96%

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Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a twocompartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 lg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 lg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20-50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to [80%, while those were reduced to around 30% by alkaline treatment.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 96%

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Uno

Chaweepack²,

Ruangpan

2010

Aquacult Int

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“…The OTC levels in the biological matrices (haemolymph, muscle and hepatopancreas) were determined using a validated HPLC method, modified from the literature (Faroongsarng et al 2007). The reversed‐phase HPLC system (Waters) consisting of a pump (Waters 510) connected to an injector (Rhedyne 7125 with injector loop 20 μL), an integrator (Waters 745 data module) with an analytical column of 4 μm, 3.9 × 150 mm, Nova Pak C 18 protected by a column guard and a UV‐visible detector (Waters 484; wavelength of 360 nm) was used.…”

Section: Methodsmentioning

confidence: 99%

“…The numerical data were fitted with differential equations of the proposed physiological model using commercial software (Systat for windows V. 12, Systat Software). In addition, as OTC entered the hepatopancreas via the foregut in oral administration, the profile of the drug in the foregut was simulated based on first‐order kinetics using the initial drug concentration of the medicated feed and the absorption constant taken from the literature (0.2986 h −1 : Faroongsarng et al 2007) in order to complete the non‐linear regression.…”

Section: Methodsmentioning

confidence: 99%

“…All studies to date describing the pharmacokinetics of oxytetracycline (OTC) in shrimp, e.g. those by Reed, Siewicki and Shah (2004, 2006), Uno (2004), Sangrungruang, Chotchuang and Ueno (2004), Uno, Aoki, Kleechaya, Tanasomwang and Ruangpan (2006), Chiayvareesajja, Chandumpai, Theapparat and Faroogsarng (2006) and Faroongsarng, Chandumpai, Chiayvareesajja and Theapparat (2007), have utilized the compartmental models. Although the models yielded the detailed rate kinetics of OTC among compartments, this type of model uses simple approximations and result in a descriptive function regarding drug profiles in biological matrices.…”

Section: Introductionmentioning

confidence: 99%

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Hepatopancreatic and muscular distribution of oxytetracycline antibiotics in farmed pacific white shrimp (Penaeus vannamei): a physiological-based pharmacokinetic model approach

Faroongsarng

Chiayvareesajja

Chandumpai

et al. 2009

Aquaculture Research

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Oxytetracycline (OTC) pharmacokinetic models previously used to investigate Penaeus vannamei have not addressed the specific problems related to drug distribution/disposition in particular tissues. This study aimed to provide an insight into OTC kinetics in the hepatopancreas and muscle based on a physiological model approach. Adult male P. vannamei at the C‐D0 inter‐moulting stage were randomly assigned to intra‐sinus and oral administrations. In the intra‐sinus group, shrimps were dosed via the ventral sinus at an OTC level of 10.0 μg g−1 body weight, while in the oral one, they were force fed at a dose level of 50.2 μg g−1. The medicated animals were sampled at various time intervals until 170 h after dosing. Haemolymph, muscle and hepatopancreas samples were taken and OTC levels were determined using the validated HPLC method. A model focused on the hepatopancreas and muscle was developed. Oxytetracycline pharmacokinetic profiles in particular tissues were fitted into the model with an R2 of between 0.6568 and 0.9904. Oxytetracycline muscular distributions were essentially identical for both groups and the drug did not accumulate in muscle. The distributions in the hepatopancreas for both groups were extensive, whereas that for oral administration was approximately 2.3 times greater than that for the intra‐sinus one. It was demonstrated that hepatopancreatic OTC may undergo significant first‐pass elimination with non‐linear kinetics.

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Pharmaceuticals in biota in the aquatic environment: analytical methods and environmental implications

2012

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The presence of pharmaceuticals in the aquatic environment is an ever-increasing issue of concern as they are specifically designed to target specific metabolic and molecular pathways in organisms, and they may have the potential for unintended effects on nontarget species. Information on the presence of pharmaceuticals in biota is still scarce, but the scientific literature on the subject has established the possibility of bioaccumulation in exposed aquatic organisms through other environmental compartments. However, few studies have correlated both bioaccumulation of pharmaceutical compounds and the consequent effects. Analytical methodology to detect pharmaceuticals at trace quantities in biota has advanced significantly in the last few years. Nonetheless, there are still unresolved analytical challenges associated with the complexity of biological matrices, which require exhaustive extraction and purification steps, and highly sensitive and selective detection techniques. This review presents the trends in the analysis of pharmaceuticals in aquatic organisms in the last decade, recent data about the occurrence of these compounds in natural biota, and the environmental implications that chronic exposure could have on aquatic wildlife.

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Bioavailability and absorption analysis of oxytetracycline orally administered to the standardized moulting farmed Pacific white shrimps (Penaeus vannamei)

Cited by 25 publications

References 15 publications

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell

Hepatopancreatic and muscular distribution of oxytetracycline antibiotics in farmed pacific white shrimp (Penaeus vannamei): a physiological-based pharmacokinetic model approach

Pharmaceuticals in biota in the aquatic environment: analytical methods and environmental implications

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