Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement

Henning, Susanne M.; Niu, Yantao; Lee, Nicolas H; Thames, Gail; Minutti, Rosario R.; Wang, He-Jing; Go, Vay Liang W.; Heber, David

doi:10.1093/ajcn/80.6.1558

Cited by 292 publications

(197 citation statements)

References 16 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…Studies on bioavailability are often conducted collecting specimens at timed intervals (after ingestion). Various studies have been conducted using normally prepared green tea beverages [14][15][16], ingested green tea extract (total catechins) [14,17,18], or ingestion of specific catechins [19][20][21]. These studies have shown that ECG and EGCG, and metabolites of EC and EGC can be detected and measured in blood plasma.…”

Section: Introductionmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

View full text Add to dashboard Cite

Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

show abstract

Section: Introductionmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

View full text Add to dashboard Cite

show abstract

“…Catechins -EGCG, (−)-epigallocatechin (EGC), (−)-epicatechin-3-gallate (ECG), and (−)-epicatechin (EC)-are important components of green tea ( Fig. 1: A, C) (11). EGCG is the most abundant polyphenol in green tea.…”

Section: Introductionmentioning

confidence: 99%

“…1: B, C) (11,19). TFDG possesses two galloyl groups as a result of the polymerization of two EGCG molecules.…”

Section: Introductionmentioning

confidence: 99%

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

et al. 2012

View full text Add to dashboard Cite

Abstract. Matrix metalloproteinases (MMPs) play an important role in degeneration of the matrix associated with bone and cartilage. Regulation of osteoclast activity is essential in the treatment of bone disease, including osteoporosis and rheumatoid arthritis. Polyphenols in green tea, particularly epigallocatechin-3-gallate (EGCG), inhibit MMPs expression and activity. However, the effects of the black tea polyphenol, theaflavin-3,3′-digallate (TFDG), on osteoclast and MMP activity are unknown. Therefore, we examined whether TFDG and EGCG affect MMP activity and osteoclast formation and differentiation in vitro. TFDG or EGCG (10 and 100 μM) was added to cultures of rat osteoclast precursors cells and mature osteoclasts. Numbers of multinucleated osteoclasts and actin rings decreased in polyphenol-treated cultures relative to control cultures. MMP-2 and MMP-9 activities were lower in TFDG-and EGCG-treated rat osteoclast precursor cells than in control cultures. MMP-9 mRNA levels declined significantly in TFDG-treated osteoclasts in comparison to control osteoclasts. TFDG and EGCG inhibited the formation and differentiation of osteoclasts via inhibition of MMPs. TFDG may suppress actin ring formation more effectively than EGCG. Thus, TFDG and EGCG may be suitable agents or lead compounds for the treatment of bone resorption diseases.

show abstract

“…The predominant TFs in black tea are theaflavin (TF1), TF-3-O-gallate (TF2A), TF-3′-Ogallate (TF2B), and TF-3,3′-O-digallate (TF3), which are synthesized with different combinations of precursors. 1) TFs have several catechin-like properties, such as antioxidative 2,3) and antivirus 4) activities, with some being equal to 2) or stronger 4) than those of catechins. Bitter taste receptors (TAS2Rs) are known to respond to bitter substances.…”

mentioning

confidence: 99%

The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins

Yamazaki

Sagisaka

Ikeda

et al. 2014

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

We purified several hundred mgs of four major theaflavins (theaflavin, theaflavin-3-O-gallate, theaflavin-3′-O-gallate, and theaflavin-3,3′-O-digallate). Among the 25 hTAS2Rs expressed in HEK293T cells, hTAS2R39 and hTAS2R14 were activated by theaflavins. Both hTAS2R39 and hTAS2R14 responded to theaflavin-3′-O-gallate. In addition, hTAS2R39 was activated by theaflavin and theaflavin-3,3′-O-gallate, but not by theaflavin-3-O-gallate. In contrast, hTAS2R14 responded to theaflavin-3-O-gallate.

show abstract

Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement

Abstract: Our observations suggest that green tea extract supplements retain the beneficial effects of green and black tea and may be used in future chemoprevention studies to provide a large dose of tea polyphenols without the side effects of caffeine associated with green and black tea beverages.

Cited by 292 publications

References 16 publications

An Update on the Health Benefits of Green Tea

An Update on the Health Benefits of Green Tea

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins

Contact Info

Product

Resources

About