Bioavailability and daily requirement of vitamin B12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [13C]-cyanocobalamin kinetics

Kurpad, Anura V.; Pasanna, Roshni M.; Hegde, Shalini G.; Patil, Mallikarjun; Mukhopadhyay, Arpita; Sachdev, Harshpal S.; Bhat, Kishor G.; Sivadas, Ambily; Devi, Sarita

doi:10.1016/j.ajcnut.2023.08.020

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…23,24 Absorption by this nonphysiological process appears to occur across the entire length of the GI tract. 25…”

Section: Requirement For Vitamin B 12 In Human Physiologymentioning

confidence: 99%

Vitamin B₁₂ Status and Supplementation in Plant-Based Diets

Hannibal,

Lederer,

Storz

et al. 2024

Food Nutr Bull

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Plant-based diets are increasingly popular worldwide. A well-planned plant-based diet lowers the risk of cardiovascular disease, type 2 diabetes and certain cancers. In contrast, a poorly planned plant-based diet increases the risk of certain micronutrient deficiencies, chiefly, vitamin B12 (B12). Because B12 is not present in plants or in unfortified plant-based foodstuffs, the safest way to prevent its deficiency in plant-based diets is to take an oral B12 supplement. Studies determining the dose and frequency of B12 to be taken by healthy individuals on a plant-based diet to support an adequate B12 status are scarce. Here, we summarize the natural sources, metabolic requirements, biomarker findings with and without supplementation with B12, and current recommendations to help prevent vitamin B12 deficiency in healthy individuals adhering or transitioning to plant-based diets. This review focuses on the prevention of vitamin B12 deficiency in healthy individuals adhering to plant-based diets. The information covered in this review does not apply to individuals suffering from autoimmune-based malabsorption of vitamin B12 resulting from pernicious anemia due to atrophic gastritis, other acquired causes of B12 malabsorption or to those with genetic disorders that impair vitamin B12 absorption, transport and utilization.

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“…23,24 Absorption by this nonphysiological process appears to occur across the entire length of the GI tract. 25…”

Section: Requirement For Vitamin B 12 In Human Physiologymentioning

confidence: 99%