Bioavailability and Erosive Activity of Some Non-Steroidal Anti-Inflammatory Drugs Solid-Dispersions

Improvement of the solubility and bioavailability of loratadine by pharmaceutical technological mtehods

“…Dispersions containing crystalline areas exhibit biphasic release profiles, with the amorphous areas dissolving quickly and the crystalline areas more slowly. For example, for a crystalline drug with a very poor aqueous solubility, the formation of an amorphous mixture with a water-soluble additive can provide an opportunity to enhance the dissolution and perhaps bioavailability [35].…”