Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols

Bansode, Rishipal R.; Randolph, Priscilla; Ahmedna, Mohamed; Williams, Leonard; Yu, Jianglong

doi:10.1089/jmf.2014.0060

Cited by 22 publications

(15 citation statements)

References 66 publications

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“…Especially, compared to peanut seeds, germinated peanuts exhibit enhanced antioxidant activity [8]. These phenolic compounds have been associated with a wide range of health benefits such as the prevention of coronary heart diseases, different types of cancer, diabetes, and obesity [9]. Given the health benefits and commercial value, it is useful to comprehensively analyze the phenolic profiles and bioactivities of germinated peanuts.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Phenolic Profiles of Soaked and Germinated Peanut Cultivars via UPLC-QTOF-MS

et al. 2019

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Diverse peanut varieties are widely cultivated in China. However, few studies have investigated the effects of germination on the phenolic profiles and antioxidant activities of specific Chinese peanut cultivars. Therefore, this study was conducted to evaluate the effects of germination on total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and phenolic profiles of seven peanut cultivars in China. The TPC, TFC, and antioxidant activities were determined by spectrophotometry, while phenolic profiles were analyzed by using ultra-high performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS). The results found that germination significantly increased TPC, TFC, and antioxidant activity. Antioxidant activity was found to be closely related to TPC in germinated peanut extracts, which indicates that phenolics are the main contributors of antioxidants in germinated peanuts. In addition, germination induced significant changes in polyphenolic profiles. In the analyzed samples, 36 phenolic compounds were identified in which most were flavonoids. Overall, these findings highlight that germinated peanuts can be a good natural source of natural antioxidants for human consumption and functional food development.

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Section: Introductionmentioning

confidence: 99%

Comparison of the Phenolic Profiles of Soaked and Germinated Peanut Cultivars via UPLC-QTOF-MS

et al. 2019

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“…19 These health benefits are attributed to the trans-fatty acids, minerals, vitamins, fibers, and bioactive compounds present in the peanut. 20 The peanut skin, a byproduct of the peanut industry, contains high levels of polyphenols which exert potent antioxidant, 21 anti-inflammatory, 22 hypolipidemic, 23 and anti-bacterial, 24 effects. Despite these studies indicating that peanut skins are a potentially rich, safe, and inexpensive source of functional ingredients and could be helpful in combating microbial infections, their antiviral activity remains to be studied.…”

mentioning

confidence: 99%

Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses

Makau

Watanabe

Mohammed

et al. 2018

Journal of Medicinal Food

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The high propensity of influenza viruses to develop resistance to antiviral drugs necessitates the continuing search for new therapeutics. Peanut skins, which are low-value byproducts of the peanut industry, are known to contain high levels of polyphenols. In this study, we investigated the antiviral activity of ethanol extracts of peanut skins against various influenza viruses using cell-based assays. Extracts with a higher polyphenol content exhibited higher antiviral activities, suggesting that the active components are the polyphenols. An extract prepared from roasted peanut skins effectively inhibited the replication of influenza virus A/WSN/33 with a half maximal inhibitory concentration of 1.3 μg/mL. Plaque assay results suggested that the extract inhibits the early replication stages of the influenza virus. It demonstrated activity against both influenza type A and type B viruses. Notably, the extract exhibited a potent activity against a clinical isolate of the 2009 H1N1 pandemic, which had reduced sensitivity to oseltamivir. Moreover, a combination of peanut skin extract with the anti-influenza drugs, oseltamivir and amantadine, synergistically increased their antiviral activity. These data demonstrate the potential application of peanut skin extract in the development of new therapeutic options for influenza management.

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“…Polyphenols can prevent reabsorption of bile acids in the small intestine by binding to them and triggering cholesterol destruction [25,26]. Bansode et al [27] concluded that low molecular weight polyphenols inhibited the intestinal transport of dietary cholesterol because of the decomposition of the bile acid-emulsified micellar structure in the intestines. In vitro bile acid binding activity is potentially related to the reduction in cholesterol content [18].…”

Section: In Vitro Hypocholesterolemic Effect Of Phenol Extracts Of DImentioning

confidence: 99%

Phenolics and related in vitro functional activities of different varieties of fresh waxy corn: a whole grain

Chen

Guo

et al. 2020

Preprint

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The polyphenol distribution in fresh waxy corns of different color varieties and their functional activities, which may be useful for treating various chronic diseases, were investigated. The in vitro antioxidant activity, and hypoglycemic and hypocholesterolemic effects of the free and bound corn phenolics were determined to evaluate the edible value of fresh waxy corn. The colored varieties contained more phenols than the common varieties (white and/or yellow). The total free phenolic acid content of the six varieties was 6637.73 μg/g DW (dry weight), which was slightly higher (P >0.05) than that of the total bound form (6276.65 μg/g DW). The total free flavonoid content was 5850.09 μg/g DW, which was higher (P < 0.05) than that of the total bound form (4874.51μg/g DW). No bound anthocyanin was detected in the methanol extracts of the tested varieties. For all the varieties, free polyphenols contributed 86-100% and 70-78% of the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging abilities, respectively, and 100% of the ferric reducing capacity. The free phenolics in fresh waxy corn showed significantly better (P < 0.05) hypoglycemic effect than the bound form in terms of inhibition of α-amylase activity, whereas the bound phenolics of most varieties showed higher α-glucosidase inhibitory activity than the free forms. The free phenolics showed significantly better (P < 0.05) glycocholesterol binding than the bound form for all varieties. The bound polyphenols showed better sodium cholate and taurocholate binding than the free form for most varieties. In conclusion, the difference between free and bound polyphenol content and functional activities indicates that fresh waxy corn can be potentially used for the development of functional food.Keywords: fresh waxy corn; polyphenol; antioxidant activity; hypoglycemic; hypocholesterol

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Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols

Cited by 22 publications

References 66 publications

Comparison of the Phenolic Profiles of Soaked and Germinated Peanut Cultivars via UPLC-QTOF-MS

Comparison of the Phenolic Profiles of Soaked and Germinated Peanut Cultivars via UPLC-QTOF-MS

Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses

Phenolics and related in vitro functional activities of different varieties of fresh waxy corn: a whole grain

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