Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge

Janga, Karthik Yadav; Jukanti, Raju; Velpula, Ashok; Sunkavalli, Sharath; Bandari, Suresh; Kandadi, Prabhakar; Veerareddy, Prabhakar Reddy

doi:10.1016/j.ejpb.2011.10.010

Cited by 88 publications

(49 citation statements)

References 39 publications

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“…Proliposomes are more stable for longer duration without significant changes during sterilization and storage (Janga et al, 2012). However, the problem of degradation of phospholipids by oxidation was still there.…”

Section: Introductionmentioning

confidence: 99%

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

et al. 2017

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Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs. They have the potential to deliver drugs effectively through different routes at specific site of action to achieve controlled release action and reduce toxic effects associated with drugs. This review discusses the general preparation techniques of proniosomes and mainly focus on the applications of proniosomes in drug delivery and targeting. Moreover, this review demonstrates critical appraisal of the literature for proniosomes. Additionally, this review extensively explains the potential of proniosomes in delivering drugs via different routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. Finally, the comparison of proniosomes with niosomes manifests the clear distinction between them. Moreover, proniosomes need to be explored for proteins and peptide delivery and in the field of nutraceuticals and develop pilot plant scale up studies to investigate them in industrial set up. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

et al. 2017

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“…Proliposomes show great flexibility in the route of administration including reconstituted parenteral, oral, topical, intranasal administration and as dry powder aerosol (210). Proliposomes have successfully been used for enhancing bioavailability of anticancer drugs and other therapeutic agents (211)(212)(213).…”

Section: Applicationsmentioning

confidence: 99%

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

et al. 2014

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-Liposomes are lipid based vesicular systems that offer novel platform for versatile drug delivery to target cell. Liposomes were first reported by Bangham and his co-workers in 1964 (1). Since then, liposomes have undergone extensive research with the prime aim to optimize encapsulation, stability, circulation time and target specific drug delivery. Manipulation of a liposome's lipid bilayer and surface decoration with selective ligands has transformed conventional liposomes into adaptable and multifunctional liposomes. Development of liposomes with target specificity provide the prospect of safe and effective therapy for challenging clinical applications. Bioresponsive liposomes offer the opportunity to release payload in response to tissue specific microenvironment. Incorporation of novel natural and synthetic materials has extended their application from stable formulations to controlled release targeted drug delivery systems. Integration and optimization of multiple features into one system revolutionized research in the field of cancer, gene therapy, immunotherapy and infectious diseases. After 50 years since the first publication, this review is aimed to highlight next generation of liposomes, their preparation methods and progress in clinical applications.

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“…However, the application of liposomes containing bile salts in oral delivery has been limited by a number of factors including drug leakage, vesicle aggregation and sedimentation, and phospholipid hydrolysis and oxidation. A proliposome formulation is adopted in the current study because it provides a key breakthrough in addressing these issues (Janga et al, 2012;Song et al, 2005;Xiao et al, 2006;Xu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats

Zheng

Teng

Xing

et al. 2015

European Journal of Pharmaceutical Sciences

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Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge

Cited by 88 publications

References 39 publications

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats

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