Bioavailability of Arsenic in Soil and House Dust Impacted by Smelter Activities Following Oral Administration in Cynomolgus Monkeys

Freeman, G. B.; Schoof, Rosalind A.; Ruby, Michael V.; Davis, Andy; Dill, Jeffrey A.; Liao, Shiyan; Lapin, Charles A.; Bergstrom, Paul D.

doi:10.1006/faat.1995.1162

Cited by 106 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Soil As RBA estimates obtained in juvenile swine and monkeys have ranged from 0% to 52% (Casteel et al 1997; Freeman et al 1995; Lorenzana et al 1996; Rees et al 2009; Roberts et al 2002; Rodriguez et al 1999). Comparisons of As RBA data obtained in mice and juvenile swine are problematic because of differences in experimental design and dosing levels.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils

Bradham

Scheckel

Nelson

et al. 2011

Environ Health Perspect

163

177

View full text Add to dashboard Cite

Background: Assessment of soil arsenic (As) bioavailability may profoundly affect the extent of remediation required at contaminated sites by improving human exposure estimates. Because small adjustments in soil As bioavailability estimates can significantly alter risk assessments and remediation goals, convenient, rapid, reliable, and inexpensive tools are needed to determine soil As bioavailability.Objectives: We evaluated inexpensive methods for assessing As bioavailability in soil as a means to improve human exposure estimates and potentially reduce remediation costs.Methods: Nine soils from residential sites affected by mining or smelting activity and two National Institute of Standards and Technology standard reference materials were evaluated for As bioavailability, bioaccessibility, and speciation. Arsenic bioavailability was determined using an in vivo mouse model, and As bioaccessibility was determined using the Solubility/Bioavailability Research Consortium in vitro assay. Arsenic speciation in soil and selected soil physicochemical properties were also evaluated to determine whether these parameters could be used as predictors of As bioavailability and bioaccessibility.Results: In the mouse assay, we compared bioavailabilities of As in soils with that for sodium arsenate. Relative bioavailabilities (RBAs) of soil As ranged from 11% to 53% (mean, 33%). In vitro soil As bioaccessibility values were strongly correlated with soil As RBAs (R2 = 0.92). Among physicochemical properties, combined concentrations of iron and aluminum accounted for 80% and 62% of the variability in estimates of RBA and bioaccessibility, respectively.Conclusion: The multifaceted approach described here yielded congruent estimates of As bioavailability and evidence of interrelations among physicochemical properties and bioavailability estimates.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Studies of soil As bioavailability have used species as diverse as rodents, swine, and monkeys (Casteel et al 1997; Freeman et al 1995; Lorenzana et al 1996; Nagar et al 2009; Ng et al 1998; Pascoe et al 1994; Rees et al 2009; Roberts et al 2002). Time and cost considerations may limit use of some species in bioavailability assays (U.S. EPA 2007a, 2007b).…”

mentioning

confidence: 99%

Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils

Bradham

Scheckel

Nelson

et al. 2011

Environ Health Perspect

163

177

View full text Add to dashboard Cite

show abstract

“…About 80–90% of ingested As[III] or As[V] is absorbed from the gastrointestinal tract [28–30]. Data derived from autopsies has determined that muscles, bones, kidneys, and lungs have the highest absolute accumulated amounts of iAs, while skin and excretory/storage organs, such as nails and hair, are the most concentrated [31].…”

Section: Arsenic Biotransformationmentioning

confidence: 99%

Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms

Martínez

Vucic

Adonis

et al. 2011

Molecular Biology International

View full text Add to dashboard Cite

Chronic exposure to arsenic in drinking water poses a major global health concern. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences, including alarming cancer incidence and death rates. Arsenic is biotransformed through sequential addition of methyl groups, acquired from s-adenosylmethionine (SAM). Metabolism of arsenic generates a variety of genotoxic and cytotoxic species, damaging DNA directly and indirectly, through the generation of reactive oxidative species and induction of DNA adducts, strand breaks and cross links, and inhibition of the DNA repair process itself. Since SAM is the methyl group donor used by DNA methyltransferases to maintain normal epigenetic patterns in all human cells, arsenic is also postulated to affect maintenance of normal DNA methylation patterns, chromatin structure, and genomic stability. The biological processes underlying the cancer promoting factors of arsenic metabolism, related to DNA damage and repair, will be discussed here.

show abstract

“…Over the past two decades, as the practice of risk assessment has matured there has been an increasing emphasis on incorporating relevant measures of environmental exposure to ensure that site assessments are realistic. During this period a body of literature was growing that indicated that metals/metalloids (typically lead and arsenic) are less well absorbed from soil by the gastrointestinal tract (Freeman et al, 1995;Ruby et al, 1999;Roberts et al, 2002Roberts et al, , 2006.…”

Section:  Relative Bioavailabilitymentioning

confidence: 99%

“…As interest grew in the site-specific bioavailability to people of metals/metalloids in contaminated soils, animal soil feeding studies with lead using a number of animal models, including juvenile swine, and with arsenic in cynomolgus monkeys, began to be undertaken at some sites in the United States -typically 'Superfund' sites (e.g., Casteel et al, 1997;Freeman et al, 1995). These studies, typically live animal feeding studies, evaluated the relative bioavailability from soils from a variety of contaminated metals sites.…”

Section:  Relative Bioavailabilitymentioning

confidence: 99%

Metal/metalloid bioavailability considerations in addressing site risk and remediation in mine closure

Robinson¹

2013

Proceedings of the Eighth International Seminar on Mine Closure

View full text Add to dashboard Cite

Current best mining practices call for mine closure planning throughout the lifecycle of a mining project, and many countries have specific guidance for developing mine closure plans. These guidelines (country-specific) are intended to address the footprint left behind from historical mining and processing activities and ensure that the post-closure condition does not represent a health risk to current or future communities and the environment (biodiversity). Among many other aspects, the closure plan should provide an approach for evaluating post-closure risk that incorporates the best available site data, including environmental (e.g., physical, chemical, biological, end-use and social data)-all of which are important for developing a site-specific post-closure risk assessment and protective site remediation levels. A key issue in characterising potential chemical exposure and risk from a closed mine site is understanding the chemical and physical processes affecting site environmental media (e.g., tailings, contaminated soil, surface water, etc.) as these characteristics influence chemical (metal/metalloid) mobility and bioavailability. Important fate characteristics influencing bioavailability include pH, soil cation exchange capacity, organic carbon content, acid volatile sulphides and redox potential. Reduced bioavailability as a result of site and media-specific physical/chemical characteristics translates to a reduction in organism (human, ecological) toxicity potential and, as illustrated for human health, in the development of more-realistic (and site-specific) remediation levels. Accordingly, understanding mine site environmental conditions affecting bioavailability is important in preparing a scientifically robust mine closure risk assessment and in developing site-specific remediation levels protective of site end uses.

show abstract

Bioavailability of Arsenic in Soil and House Dust Impacted by Smelter Activities Following Oral Administration in Cynomolgus Monkeys

Cited by 106 publications

References 0 publications

Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils

Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils

Arsenic Biotransformation as a Cancer Promoting Factor by Inducing DNA Damage and Disruption of Repair Mechanisms

Metal/metalloid bioavailability considerations in addressing site risk and remediation in mine closure

Contact Info

Product

Resources

About