Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Vale, Gonçalo; Franco, Catarina; Diniz, Mário; Santos, Margarida M. Correia dos; Domingos, Rute F.

doi:10.1016/j.ecoenv.2014.07.035

Cited by 59 publications

(18 citation statements)

References 44 publications

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“…Moreover, exposure to nano-TiO 2 induced oxidative stress and lysosomal membrane alteration in the digestive gland of mussels910. In addition, some other molecular and functional parameters of digestive gland can be affected by nano-TiO 2 in mussels1259. These results further verify the hypothesis that NPs can enter the digestive system which is a typical target for NP toxic effect in mussels.…”

Section: Discussionsupporting

confidence: 68%

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Lin

Shang

et al. 2017

Sci Rep

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The increasing usage of nanoparticles has caused their considerable release into the aquatic environment. Meanwhile, anthropogenic CO2 emissions have caused a reduction of seawater pH. However, their combined effects on marine species have not been experimentally evaluated. This study estimated the physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus under high pCO2 (2500–2600 μatm). We found that respiration rate (RR), food absorption efficiency (AE), clearance rate (CR), scope for growth (SFG) and O:N ratio were significantly reduced by nano-TiO2, whereas faecal organic weight rate and ammonia excretion rate (ER) were increased under nano-TiO2 conditions. High pCO2 exerted lower effects on CR, RR, ER and O:N ratio than nano-TiO2. Despite this, significant interactions of CO2-induced pH change and nano-TiO2 were found in RR, ER and O:N ratio. PCA showed close relationships among most test parameters, i.e., RR, CR, AE, SFG and O:N ratio. The normal physiological responses were strongly correlated to a positive SFG with normal pH and no/low nano-TiO2 conditions. Our results indicate that physiological functions of M. coruscus are more severely impaired by the combination of nano-TiO2 and high pCO2.

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Section: Discussionsupporting

confidence: 68%

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Lin

Shang

et al. 2017

Sci Rep

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“…57 TiO 2 NPs are of great ecotoxicological interest due to their potential to alter the bioavailability and thus the toxicity of coexisting contaminants like heavy metals or organic compounds in aquatic organisms like fish and bivalves. [58][59][60][61][62][63] For the evaluation of the bioaccumulation potential of the MNMs applied in this study, total metal concentrations were analysed in the whole animals and the distribution of accumulated material in the soft tissue was determined. In addition, particle concentrations and particle sizes were measured in the different tissue compartments of the animals to allow the differentiation between bioaccumulation of dissolved and particulate material.…”

Section: Introductionmentioning

confidence: 99%

Testing the bioaccumulation of manufactured nanomaterials in the freshwater bivalveCorbicula flumineausing a new test method

Kuehr

Meisterjahn

Schröder

et al. 2020

Environ. Sci.: Nano

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Increasing amounts of manufactured nanomaterials (MNMs) are produced for their industrial use and released to the environment by the usage or disposal of the products. As depending on their annual production rate, substances are subjected to PBT assessment, the availability of reliable methods to evaluate these endpoints for (corresponding) nanoforms/MNMs becomes relevant. The classical method to elucidate the bioaccumulation potential of chemicals has been the flow-through study with fish, which has limitations as regards meeting the requirements of MNMs. Most MNMs tend to sediment in the aquatic environment. Thus, maintenance of stable exposure conditions for bioaccumulation testing with fish is nearly impossible to achieve when using MNMs. Corbicula fluminea, a freshwater filter-feeding bivalve distributed worldwide, has been previously shown to ingest and accumulate MNMs present in the water phase. To investigate the suitability of C. fluminea for bioaccumulation testing we developed a new flowthrough system to expose mussels under constant exposure conditions. Two nanoparticles (NPs), the AgNP NM 300K and the TiO 2 NP NM 105, were applied. In addition, C. fluminea was exposed to AgNO 3 as a source of dissolved Ag + to compare the bioaccumulation of Ag in dissolved and nanoparticulate forms. For each MNM exposure scenario we were able to determine steady-state bioaccumulation factors. BAF ss values of 31 and 128 for two NM 300K concentrations (0.624 and 6.177 μg Ag per L) and 6150 and 9022for TiO 2 (0.099 and 0.589 μg TiO 2 per L) showed the exposure dependence of the BAF ss estimates. The progression of metal uptake and elimination in the soft tissue provided clear indications that the uptake and thus accumulation is mainly driven by the uptake of NPs and less of dissolved ions.Filter-feeding organisms such as bivalves represent a major target for the bioaccumulation of nanomaterials in the aquatic environment. Therefore, bivalves should be considered as test organisms for the bioaccumulation assessment of nanomaterials. A new flow-through system to expose the freshwater bivalves under constant exposure conditions was developed. Bioaccumulation studies with the freshwater bivalve C. fluminea on two nanoparticles, the AgNP NM 300K and the TiO 2 NP NM 105, demonstrated the suitability of the new test system. The results obtained with this test system can be used to generate useful endpoints required for regulatory purposes and could be included in a tiered bioaccumulation testing strategy for manufactured nanomaterials.

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“…However, in the green algae Chlamydomonas reinhardtii, Cd 2þ toxicity as well as accumulation seemed to be reduced by n-TiO 2 (Yang et al, 2012), and no influence of n-TiO 2 was observed on Cd 2þ uptake on Lumbriculus variegatus (Hartmann et al, 2012). In the freshwater bivalve Corbicula fluminea, Cd 2þ uptake and antioxidant biomarker responses were unaffected by the presence of n-TiO 2 , despite n-TiO 2 significantly reducing the free Cd 2þ content in the medium (Vale et al, 2014). Overall, although available data indicate changes in bioavailability/uptake/bioaccumulation of Cd 2þ in the presence of n-TiO 2 , probably due to sorption of the metal to n-TiO 2 in freshwater media, no clear evidence of increased toxicity is provided.…”

Section: Interactive Effects Of Carbon-based Nps With Other Contaminantsmentioning

confidence: 50%

Interactive effects of nanoparticles with other contaminants in aquatic organisms: Friend or foe?

Canesi

Ciacci

Balbi

2015

Marine Environmental Research

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Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Cited by 59 publications

References 44 publications

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus

Testing the bioaccumulation of manufactured nanomaterials in the freshwater bivalveCorbicula flumineausing a new test method

Interactive effects of nanoparticles with other contaminants in aquatic organisms: Friend or foe?

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