Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization

López-Lluch, Guillermo; Pozo-Cruz, Jesús del; Sánchez-Cuesta, Ana; Cortés-Rodríguez, Ana Belén; Navas, Plácido

doi:10.1016/j.nut.2018.05.020

Cited by 115 publications

(88 citation statements)

References 41 publications

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“…Interestingly, in a single-dose (100 mg) study on older participants (>60 years), Evans et al [19] reported more distinct differences between the bioavailabilities of ubiquinol and ubiquinone formulations; however, they did not test water-soluble CoQ10 formulations. On the other hand, López-Lluch et al have recently reported the results of their single-dose study (100 mg CoQ10, several different formulations) on healthy young participants (18-33 years), where a ubiquinone formulation was notably more bioavailable than ubiquinol [29].…”

Section: Discussionmentioning

confidence: 99%

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

et al. 2020

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Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65–74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital® water-soluble CoQ10 syrup (the investigational product—IP); ubiquinol capsules (the comparative product—CP); and ubiquinone capsules (the standard product—SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (ΔAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3–4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9–3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.

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Section: Discussionmentioning

confidence: 99%

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

et al. 2020

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“…Another limitation of our study was that there is no negative control, i.e., meals alone. In the previous reports, there was no placebo control for the determination of the absorption/bioavailability of CoQ 10 supplements [25][26][27][52][53][54][55]. Also, the effect of CoQ 10 contents in the provided meals seemed to be extremely low as the estimated CoQ 10 amount was less than one two-hundredth of the CoQ 10 supplements ingested.…”

Section: Discussionmentioning

confidence: 98%

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀

Τakahashι

Nagata

Kaneko

et al. 2020

Journal of Nutrition and Metabolism

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Coenzyme Q10 (CoQ10) is an essential compound that is involved in energy production and is a lipid-soluble antioxidant. Although it has been proposed as an antiaging and a health-supporting supplement, its low bioavailability remains a significant issue. Concurrent food intake enhances the absorption of orally administered CoQ10, but it has not been fully established whether specific food substances affect intestinal CoQ10 absorption. Therefore, to determine whether the bioavailability of supplemental CoQ10 is affected by diet, P30, a granulated and reduced form of CoQ10, was dispersed in four different foods, clear soup, miso soup, milk soup, and raw egg sauce. Those foods which contained CoQ10 were consumed on different occasions at intervals of 6–14 weeks by the same participants. Thirteen participants were recruited in the single-dose and repeated clinical study. When miso soup containing P30 was provided, the serum CoQ10 concentration increased faster than when participants consumed other P30-containing soups or a P30-containing raw egg sauce. The area under the curve for serum CoQ10 during the first 5 h after consumption of the P30-containing miso soup was approximately 1.5 times larger than those after the consumption of other P30-containing meals. These data imply that the absorption of CoQ10 supplements can be enhanced by consuming them with food and in particular with specific food substances, such as miso soup.

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“…Secondly, mitochondrial inefficiency could be targeted during synaptogenesis in affected children using a variety of relatively safe therapeutic agents, such as CoQ 10 80 . Although CoQ 10 has low bioavailability and must be administered in high doses to achieve brain penetration, such an agent could be seamlessly incorporated into future multimodal therapeutic approaches to treat FXS 81,82 …”

Section: Discussionmentioning

confidence: 99%

Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome

Griffiths

Wang

et al. 2020

FASEB j.

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Fragile X syndrome (FXS) is the leading known inherited intellectual disability and the most common genetic cause of autism. The full mutation results in transcriptional silencing of the Fmr1 gene and loss of fragile X mental retardation protein (FMRP) expression. Defects in neuroenergetic capacity are known to cause a variety of neurodevelopmental disorders. Thus, we explored the integrity of forebrain mitochondria in Fmr1 knockout mice during the peak of synaptogenesis. We found inefficient thermogenic respiration due to futile proton leak in Fmr1 KO mitochondria caused by coenzyme Q (CoQ) deficiency and an open cyclosporine‐sensitive channel. Repletion of mitochondrial CoQ within the Fmr1 KO forebrain closed the channel, blocked the pathological proton leak, restored rates of protein synthesis during synaptogenesis, and normalized the key phenotypic features later in life. The findings demonstrate that FMRP deficiency results in inefficient oxidative phosphorylation during the neurodevelopment and suggest that dysfunctional mitochondria may contribute to the FXS phenotype.

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Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization

Cited by 115 publications

References 41 publications

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀

Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome

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Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization

Cited by 115 publications

References 41 publications

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals

Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q10

Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome

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Miso Soup Consumption Enhances the Bioavailability of the Reduced Form of Supplemental Coenzyme Q₁₀