Bioavailability of Dietary Carotenoids: Intestinal Absorption and Metabolism

Nagao, Akihiko

doi:10.6090/jarq.48.385

Cited by 55 publications

(32 citation statements)

References 24 publications

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“…; During & Harrison ; Fernandez‐Garcia et al . ; Nagao ). Carotenoid absorption within the mammalian gastrointestinal tract generally involves the following major steps: (i) release of carotenoids from food matrix; (ii) solubilization of carotenoids into mixed lipid micelles; (iii) cellular uptake of carotenoids by intestinal absorptive cells (enterocytes); (iv) incorporation of carotenoids into chylomicrons; (v) secretion of carotenoids and their metabolites associated with chylomicrons into the lymph within the systemic circulation and; (vi) tissue distribution, metabolism and recycling of carotenoids (van het Hof et al .…”

Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

“…The principle mechanisms modulating the pharmacokinetics of astaxanthin in mammalian and nonmammalian systems have not been completely demonstrated. Few scientific literatures to date have reviewed the different steps of absorption, transport and tissue uptake of dietary carotenoids in mammals, including humans (Furr & Clark 1997;Castenmiller & West 1998;Lee et al 1999;During & Harrison 2004;Fernandez-Garcia et al 2012;Nagao 2014). Carotenoid absorption within the mammalian gastrointestinal tract generally involves the following major steps: (i) release of carotenoids from food matrix; (ii) solubilization of carotenoids into mixed lipid micelles; (iii) cellular uptake of carotenoids by intestinal absorptive cells (enterocytes); (iv) incorporation of carotenoids into chylomicrons; (v) secretion of carotenoids and their metabolites associated with chylomicrons into the lymph within the systemic circulation and; (vi) tissue distribution, metabolism and recycling of carotenoids (van het Hof et al 2000;Thyssandier et al 2001;Olson 2004;Harrison 2012).…”

Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

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Astaxanthin as feed supplement in aquatic animals

Lim

Yusoff

Shariff

et al. 2017

Reviews in Aquaculture

307

208

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Astaxanthin is a high value keto‐carotenoid pigment renowned for its commercial application in various industries comprising aquaculture, food, cosmetic, nutraceutical and pharmaceutical. Among the verified bio‐resources of astaxanthin are red yeast Phaffia rhodozyma and green alga Haematococcus pluvialis. The supreme antioxidant property of astaxanthin reveals its tremendous potential to offer manifold health benefits among aquatic animals which is a key driving factor triggering the upsurge in global demand for the pigment. Numerous scientific researches devoted over a number of years have persistently demonstrated the instrumental role of astaxanthin in targeting several animal health conditions. This review article evaluates the current best available evidence to judge the beneficial usage of astaxanthin in aquaculture industry. Most apparent is the profound effect on pigmentation, where astaxanthin is frequently utilized as an additive in formulated diets to boost and improve the coloration of many aquatic animal species, and subsequently product quality and price. Moreover, the wide range of other physiological benefits that this biological pigment confers to these animals is also presented which include various improvements in survival, growth performance, reproductive capacity, stress tolerance, disease resistance and immune‐related gene expression.

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Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

Section: Pharmacokinetics Of Astaxanthinmentioning

confidence: 99%

Astaxanthin as feed supplement in aquatic animals

Lim

Yusoff

Shariff

et al. 2017

Reviews in Aquaculture

307

208

View full text Add to dashboard Cite

show abstract

“…However, the tomato matrix seemed to improve the retention of the ketocarotenoids in the fillets by nearly twofold (Table 1). Additional work is required to ascertain the mechanism underlying these important phenomena, although we speculate that the lipid microenvironment within the material may enhance ketocarotenoid absorption into the gastrointestinal tract of the trout, as fat and oil are known to improve carotenoid solubilization into micelles and therefore their bioavailability (16). Furthermore, analysis of the carotenoid distribution in the specific organs/tissues of the trout (fillet, eye, and liver) showed that distinct chemical classes of carotenoids were deposited in a differential manner (SI Appendix, Tables S5 and S6).…”

Section: Discussionmentioning

confidence: 99%

“…The high β-carotene line used in this study (RI) derives from the crossing of the cultivated tomato S. lycopersicum [LA4024 in the Tomato Genetics Resource Center (TGRC) database] with the wild S. galapagense accession (LA0483 in the TGRC database) (12,13). Two ZW events (10)(11)(12)(10)(11)(12)(13)(14)(15)(16)(17) were crossed with two RI lines (RI33 and RI1). The lines were cross-pollinated.…”

Section: Methodsmentioning

confidence: 99%

Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed

Nogueira

Enfissi

Valenzuela

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Ketocarotenoids are high-value pigments used commercially across multiple industrial sectors as colorants and supplements. Chemical synthesis using petrochemical-derived precursors remains the production method of choice. Aquaculture is an example where ketocarotenoid supplementation of feed is necessary to achieve product viability. The biosynthesis of ketocarotenoids, such as canthaxanthin, phoenicoxanthin, or astaxanthin in plants is rare. In the present study, complex engineering of the carotenoid pathway has been performed to produce high-value ketocarotenoids in tomato fruit (3.0 mg/g dry weight). The strategy adopted involved pathway extension beyond β-carotene through the expression of the β-carotene hydroxylase (CrtZ) and oxyxgenase (CrtW) from Brevundimonas sp. in tomato fruit, followed by β-carotene enhancement through the introgression of a lycopene β-cyclase (β-Cyc) allele from a Solanum galapagense background. Detailed biochemical analysis, carried out using chromatographic, UV/VIS, and MS approaches, identified the predominant carotenoid as fatty acid (C14:0 and C16:0) esters of phoenicoxanthin, present in the S stereoisomer configuration. Under a field-like environment with low resource input, scalability was shown with the potential to deliver 23 kg of ketocarotenoid/hectare. To illustrate the potential of this "generally recognized as safe" material with minimal, low-energy bioprocessing, two independent aquaculture trials were performed. The plant-based feeds developed were more efficient than the synthetic feed to color trout flesh (up to twofold increase in the retention of the main ketocarotenoids in the fish fillets). This achievement has the potential to create a new paradigm in the renewable production of economically competitive feed additives for the aquaculture industry and beyond.carotenoids | genetic intervention | tomato | aquaculture | industrial biotechnology

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“…Estes compostos são isoprenóides sintetizados por plantas e microorganismos (NAGAO, 2014 Esta tem sido alvo de diversos estudos relacionados à prática de exercícios físicos GUIMARÃES, SILVA, 2013;XAVIER et al, 2015) mostrando contribuição no aumento do gasto calórico e na queima de gordura.…”

Section: Consumo De Carotenóidesunclassified

Consumo alimentar e estilo de vida: um estudo longitudinal com estudantes universitários

Cardoso¹

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Bioavailability of Dietary Carotenoids: Intestinal Absorption and Metabolism

Cited by 55 publications

References 24 publications

Astaxanthin as feed supplement in aquatic animals

Astaxanthin as feed supplement in aquatic animals

Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed

Consumo alimentar e estilo de vida: um estudo longitudinal com estudantes universitários

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