Bioavailability of lutein in humans from intrinsically labeled vegetables determined by LC-APCI-MS11Financial Support: NATO Collaborative Linkage Grant “Determination of Carotenoid Biometabolites Using Advanced HPLC, NMR and MS” (No. 978601), the USDA-CSREES-NRI (99-35200-7564), and USDA ARS Nos. 581950-9-001 and 58-6250-6-001. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the US Dept. of Agricultur

Lienau, Annette; Glaser, Tobias; Tang, Guangwen; Dolnikowski, Gregory G.; Grusak, Michael A.; Albert, Klaus

doi:10.1016/j.jnutbio.2003.08.004

Cited by 57 publications

(8 citation statements)

References 32 publications

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“…How to set the amount of L supplements and the use of methods, in order to achieve the purpose of avoiding the occurrence of yellow skin? Studies have shown that in the human body, it takes 14–16 h for plasma concentration of L to reach its peak following intake [ 181 , 182 ]. About the half-life in blood and cleared time difference between the results of study, some studies suggest that plasma L has a half-life of about 76 days [ 183 ]; studies also have shown that L is cleared in only 528 h (that is 22 days) [ 184 ].…”

Section: Discussionmentioning

confidence: 99%

The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases

Jia

Sun

et al. 2017

Molecules

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Lutein (L) and zeaxanthin (Z) are dietary carotenoids derived from dark green leafy vegetables, orange and yellow fruits that form the macular pigment of the human eyes. It was hypothesized that they protect against visual disorders and cognition diseases, such as age-related macular degeneration (AMD), age-related cataract (ARC), cognition diseases, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, uveitis and diabetic retinopathy. The mechanism by which they are involved in the prevention of eye diseases may be due their physical blue light filtration properties and local antioxidant activity. In addition to their protective roles against light-induced oxidative damage, there are increasing evidences that L and Z may also improve normal ocular function by enhancing contrast sensitivity and by reducing glare disability. Surveys about L and Z supplementation have indicated that moderate intakes of L and Z are associated with decreased AMD risk and less visual impairment. Furthermore, this review discusses the appropriate consumption quantities, the consumption safety of L, side effects and future research directions.

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Section: Discussionmentioning

confidence: 99%

The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases

Jia

Sun

et al. 2017

Molecules

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“…Lienau et al. (2003) reported that 12.8%–26.2% of lutein in vegetables can be absorbed by humans. Lutein and zeaxanthin in egg yolk were also found to be of high bioavailable (Handelman et al., 1999).…”

Section: Bioavailability Of Wheat Phytochemicalsmentioning

confidence: 99%

A comprehensive review of wheat phytochemicals: From farm to fork and beyond

Tian

Zheng

Wang

et al. 2022

Comp Rev Food Sci Food Safe

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The health benefits of whole wheat consumption can be partially attributed to wheat's phytochemicals, including phenolic acids, flavonoids, alkylresorcinols, carotenoids, phytosterols, tocopherols, and tocotrienols. It is of increasing interest to produce whole wheat products that are rich in bioactive phytochemicals. This review provides the fundamentals of the chemistry, extraction, and occurrence of wheat phytochemicals and includes critical discussion of several long-lasting issues: (1) the commonly used nomenclature on distribution of wheat phenolic acids, namely, soluble-free, soluble-conjugated, and insolublebound phenolic acids; (2) different extraction protocols for wheat phytochemicals; and (3) the chemistry and application of in vitro antioxidant assays. This review further discusses recent advances on the effects of genotypes, environments, field management, and processing techniques including ultrafine grinding, germination, fermentation, enzymatic treatments, thermal treatments, and food processing. These results need to be interpreted with care due to varied sample preparation protocols and limitations of in vitro assays. The bioaccessibility, bioavailability, metabolism, and potential health benefits of wheat phytochemicals are also reviewed. This comprehensive and critical review will benefit scientific researchers in the field of bioactive compounds of cereal grains and also those in the cereal food industry to produce high-quality functional foods.

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“…Having such biological functions, lutein is not synthesized de nova in the human body and must be obtained through diet [4]. However, the bioavailability of lutein from food, fruits and raw vegetables is relatively poor (≤ 10-15%) due to its association with a complex matrix [5]. Hence, various commercial formulations have emerged in the market to tackle lutein scarcity (6-10 mg/day).…”

Section: Introductionmentioning

confidence: 99%

Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of retinal protective carotenoid lutein in rat model

Toragall

Godhwani

Baskaran

et al. 2021

Preprint

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There is excessive interest in emerging colloidal delivery systems to enhance the water solubility and oral bioavailability of lutein, which is a hydrophobic carotenoid claimed to possess health benefits. The present study aimed to design lutein-enriched nanoemulsions with improved physicochemical properties and to achieve various health benefits of lutein. The prepared lutein nanoemulsion was characterized, and its bioavailability was examined in vitro (simulated gastrointestinal digestion) and in vivo. The mean size, PDI and zeta potential of the lutein nanoemulsion were 110 ± 8 nm, 0.271 and 36 ± 2 mV, respectively. Furthermore, TEM examination revealed that the particles are nanosized and spherical in shape. Notably, the aqueous solubility of the nanoemulsion was 726-fold higher than that of free lutein. The composite nanoemulsion also showed exceptionally higher (87.4%) in vitro bioaccessibility than that of nonencapsulated or free lutein (15%). The in vivo bioavailability of lutein nanoemulsion (112.6 ng/mL) was much higher than that of nonencapsulated lutein (48.6 ng/ml) and mixed micelles (68.5 ng/mL), and the tissue distribution pattern of lutein nanoemulsion showed higher lutein accumulation in the liver (2.80- and 1.70-fold) and eye (1.91- and 1.48-fold) compared to free lutein and mixed micelle-fed groups. These results suggested that oleic acid-linoleic acid composite nanoemulsions may be a promising delivery system for lutein and may help enhance the solubility, oral bioavailability and bioefficacy of lutein and could be used as an ingredient for the formulation of beverages or functional foods.

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Cited by 57 publications

References 32 publications

The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases

The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases

A comprehensive review of wheat phytochemicals: From farm to fork and beyond

Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of retinal protective carotenoid lutein in rat model

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