Bioavailability of methionine hydroxy analog‐free acid relative to DL‐methionine in broilers

Payne, Robert; Lemme, A.; Seko, Hiroaki; Hashimoto, Yasushi; Fujisaki, Hirokazu; Koreleski, J.; Świątkiewicz, Sylwester; Szczurek, W.; Rostagno, Horatio

doi:10.1111/j.1740-0929.2006.00369.x

Cited by 23 publications

(22 citation statements)

References 17 publications

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“…This result shows that there was 15.29 and 9.73% improvement in gain and 8.43 and 6.27% in feed conversion, respectively, for both DLM-65 and DL-HMB. These results differed from those previously reported by Payne et al (2006) and Viana et al (2009), who observed similar performance responses in birds that were supplemented with increasing levels of DL-HMB or DLM in an amount equivalent to 65% according to the amount of each level of DL-HMB.…”

Section: Resultscontrasting

confidence: 57%

“…According to the studied bioavailability values for weight gain and feed conversion, the average bioavailability of DL-HMB was 42% compared to that of DLM. However, some studies (Lemme et al, 2002;Jansman et al 2003;Hoehler et al, 2005b;Payne et al, 2006) have obtained average values of bioavailability concerning DL-HMB in relation to DLM that ranged from 57 to 65%. These variations of bioavailability values are common and essential because they are estimated using biological assays.…”

Section: Resultsmentioning

confidence: 99%

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Bioavailability of different methionine sources for broilers from 1 to 21 days old

et al. 2015

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. 2015. Bioavailability of different methionine sources for broilers from 1 to 21 days old. Cien. Inv. Agr. 42(1): 35-43. This trial aimed to evaluate the bioavailability of DL-2-hydroxy-4-(methyl) butanoic acid (DL-HMBA) and a poly-herbal ingredient (PHI) in relation to DL-methionine (DLM) on broilers. A sample of 1100 broiler chickens of the Cobb 500 strain, both male and female, were fed either a basal diet without industrial methionine supplementation or a basal diet that was supplemented with three DL-HMBA levels (0.170, 0.340, and 0.511%) or three DLM levels (0.111, 0.221, and 0.332%) in an amount equivalent to 65% of the respective DL-HMBA levels (on a product weight basis) and three levels of PHI (0.111, 0.221, and 0.332%) in amounts equivalent to the used DLM levels from 1 to 21 days of age. The simultaneous linear regression analysis (slope ratio) revealed a relative bioavailability of DL-HMBA of 39% compared to that of DLM for weight gain and 44% for feed conversion. However, the performance data from birds that were supplemented with PHI did not significantly adjust to simultaneous regression designs; therefore, it was not possible to determine the PHI bioavailability in relation to the DLM. Considering together all of the studied parameters, the relative bioavailability of DL-HMBA was 42% compared to the DLM on a product basis.

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Section: Resultscontrasting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Bioavailability of different methionine sources for broilers from 1 to 21 days old

et al. 2015

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“…Many of these studies compared the effectiveness of two major commercial sources of supplementation available on the market, DL-methionine and methionine hydroxy analog, on characteristics such as weight gain and feed efficiency (Lemme et al, 2002;Bunchasak et al, 2006;Payne et al, 2006). Differences between MHA-FA and DL-methionine are due to chemical composition of the two sources: MHA-FA formulation is composed not only by monomers of methionine, but 12% water and impurities, while DL-methionine is composed of a 99% amino acid monomer powdery substance (Lemme et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Dietary methionine effects on IGF-I and GHR mRNA expression in broilers

Gasparino

Ar³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. This study aimed to evaluate liver and breast muscle insulin-like growth factor I (IGF-I) and growth hormone receptor (GHR) gene expression between broilers fed different methionine levels and sources. Broiler chicks were 22 to 42 days old, distributed in 5 treatments (control diet, DL1 -0.08% DL-methionine, DL2 -0.24% DL-methionine, MHA-FA1 -0.11% methionine hydroxy analoguefree acid, and MHA-FA2 -0.33% methionine hydroxy analogue-free acid). The broilers were euthanized by cervical dislocation. RNA was extracted from liver and breast muscle, followed by cDNA synthesis and amplification using qRT-PCR. DL2 methionine supplementation provided best animal performance results. GHR and IGF-I gene expression in the muscle tissue was not affected by methionine supplementation. IGF-I gene expression in the liver was higher in animals fed methionine supplementation than in animals fed control diet. IGF-I mRNA levels in broilers fed DL2 were greater than DL1 (1.56 vs 0.97 AU) and greater than MAH-FA1 and MAH-FA2. Broilers 6415 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6414-6423 (2013) Gene expression in broilers fed DL2 increased significantly GHR gene expression in the liver than animals fed the control diet. Addition of methionine improved animal performance by stimulating synthesis and release of growth factor.

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“…Both D-and L-isomers of MHA-Ca must be converted to L-Met whereas only D-isomers of DL-Met have to be converted (Dilger and Baker, 2008), thus allowing for a more efficient utilization of DL-Met for body protein synthesis (Payne et al, 2006). The process includes a unique oxidation step for each of the three compounds yielding keto-Met as an intermediate followed by a common transamination step to L-Met.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

Opapeju

Htoo

Dapoza³

et al. 2012

Animal

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This study assessed the efficacy of a calcium salt of methionine hydroxy analog (MHA-Ca, 84%) relative to DL-methionine 99%) in starter pigs. In Experiment 1 (Exp. 1, N balance trial), 42 individually housed barrows (Genesus, average initial BW 19 kg) were used in two blocks of 21 pigs each with six replicates per treatment. Within each block, pigs were randomly allotted to seven diets: a methionine (Met)-deficient basal diet or the basal diet with three added levels of DL-Met (0.02%, 0.04% and 0.06%) or MHA-Ca (0.024%, 0.048% and 0.071%) on an equimolar basis. After a 7-day adaptation period, feces and urine were collected quantitatively for 5 days. Urinary and total N outputs decreased linearly (P , 0.05) with DL-Met or MHA-Ca supplementation. Nitrogen retention, expressed as g/day and as % of intake increased linearly (P , 0.01) with DL-Met and MHA-Ca supplementations. The relative efficacy of MHA-Ca to DL-Met was estimated to be 71.2% on a product-to-product basis for N retention expressed as % of intake. In Exp. 2 (performance trial), 280, 21-day-old crossbred (Pietrain 3 (Landrace 3 Large White)) pigs (eight pigs per pen, seven pens per treatment), were allocated to five diets in a completely randomized block design after a 10-day adaptation period. The Met-deficient basal diet contained 16.5% CP and 0.21% Met. Other diets were basal diet supplemented with two graded levels of DL-Met (0.04% and 0.08%) or MHA-Ca (0.062% and 0.12%) on a product basis at a DL-Met to MHA-Ca ratio of 65 : 100 at the expense of maize. BW and feed disappearance were monitored weekly for 3 weeks to determine performance. Final BW, average daily gain and average daily feed intake increased (P , 0.05) and feed to gain ratio decreased (P , 0.05) with the addition of Met to the basal diet irrespective of the source. Overall, the N retention results of Exp. 1 showed that the average relative bioavailability of MHA-Ca to DL-Met to support N retention (% of N intake) was 71% on a product-to-product basis (85% on an equimolar basis). In Exp. 2, pig performance was not different when Met was supplemented in the Met-deficient diet at a DL-Met to MHA-Ca ratio of 65 : 100 on a product basis.

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Bioavailability of methionine hydroxy analog‐free acid relative to DL‐methionine in broilers

Cited by 23 publications

References 17 publications

Bioavailability of different methionine sources for broilers from 1 to 21 days old

Bioavailability of different methionine sources for broilers from 1 to 21 days old

Dietary methionine effects on IGF-I and GHR mRNA expression in broilers

Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

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