Bioavailability of oxytetracycline in sea bass, <i>Dicentrarchus labrax</i> (L.)

Rigos, George; Nengas, Ioannis; Alexis, M.N.; Athanassopoulou, F.

doi:10.1046/j.1365-2761.2003.00510.x

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…, 2 0 1 0 ) . H o w e v e r , unmetabolised oxytetracycline can be passed unabsorbed through the body of treated sparids and then excreted via the faeces into the local marine environment (Rigos & Troisi, 2005;Rigos et al, 2004). …”

Section: Drug Metabolism In Fishmentioning

confidence: 99%

Antibacterial Drugs in Fish Farms: Application and Its Effects

Sekkin¹,

Kum²

2011

Recent Advances in Fish Farms

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The world keeps changing. There are always risks associated with change. To make careful risk assessment it is always needed to re-evaluate the information according to new findings in research. Scientific knowledge is essential in determining the strategy for fish farming. This information should be updated and brought into line with the required conditions of the farm. Therefore, books are one of the indispensable tools for following the results in research and sources to draw information from. The chapters in this book include photos and figures based on scientific literature. Each section is labeled with references for readers to understand, figures, tables and text. Another advantage of the book is the "systematic writing" style of each chapter. There are several existing scientific volumes that focus specially on fish farms. The book consists of twelve distinct chapters. A wide variety of scientists, researchers and other will benefit from this book.

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Section: Drug Metabolism In Fishmentioning

confidence: 99%

Antibacterial Drugs in Fish Farms: Application and Its Effects

Sekkin¹,

Kum²

2011

Recent Advances in Fish Farms

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“…Incomplete absorption of the drug was observed in all euryhaline fish species tested (Rigos et al, 2003a2004a, b). The bioavailability (F%) of OTC has been found to be higher in European sea bass (22%) (Rigos et al, 2004a) compared to gilthead sea bream (9%) (Rigos et al, 2003a), while F was almost negligible in sharpsnout sea bream (Rigos et al, 2004b). Therefore, a significant fraction of the administered OTC is not found in the circulation of euryhaline fish.…”

Section: Tetracyclinesmentioning

confidence: 99%

“…However, the chemical behavior and kinetic profiles of these two drugs in other food-producing animal species, has been shown to be very similar (EMEA, 1995a). The pharmacokinetics of OTC have been extensively investigated in experimental studies of euryhaline farmed fish species including European sea bass, gilthead sea bream and sharpsnout sea bream (Malvisi et al, 1996;Rigos et al, 2002aRigos et al, , 2003aRigos et al, , 2004a (Table 6). Incomplete absorption of the drug was observed in all euryhaline fish species tested (Rigos et al, 2003a2004a, b).…”

Section: Tetracyclinesmentioning

confidence: 99%

“…Maximum plasma OTC concentration in gilthead sea bream and European sea bass following a single oral administration has been reported to be $2.6 lg mL )1 (Rigos et al, 2003a(Rigos et al, , 2004a. Penetration of OTC in the tissue compartment of euryhaline fish is significant since the apparent volume of distribution at steady-state Table 6.…”

Section: Tetracyclinesmentioning

confidence: 99%

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Antibacterial Agents in Mediterranean Finfish Farming: A Synopsis of Drug Pharmacokinetics in Important Euryhaline Fish Species and Possible Environmental Implications

Rigos

Troisi

2005

Rev Fish Biol Fisheries

120

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“…The residue of OTC and TC has been investigated in several farmed fish species including flounder, following intramuscular or oral administration [10][11][12][18][19][20]. However, there is scarcely the research for the residue of tetracycline antibiotics in tissue of farmed fishes after dipping administration.…”

mentioning

confidence: 99%

Application of a Solid-Phase Fluorescence Immunoassay to Determine Oxytetracycline and Tetracycline Residues in Tissue of Olive Flounder (<i>Paralichthys olivaceus</i>)

Kim

Chung

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Parallux TM , a solid-phase fluorescence immunoassay (SPFIA) developed for antibotics residue detection in milk, was applied for analysis of fish tissue. The recommended therapeutic doses of oxytetracycline (OTC, 100 g/ton water, withdrawal period 30 days) and tetracycline (TC, 150 g/ton water, withdrawal period 30 days) were treated to a group of 35 olive flounders (Paralichthys olivaceus) using dipping administration. Muscle was sampled before and after drug treatment 1st, 2nd, 3rd, 5th, 7th, and 14th day. The concentration of oxytetracycline in muscle, determined by SPFIA, was compared with that of internal standard (100 ppb as oxytetracycline). The S/C ratio of sample inhibition value to cutoff inhibition value was employed as an index to determine the muscle residue in olive flounder. To investigate the recovery rate, and standard solutions were added to muscle samples to give final concentrations in muscle of 0.1 and 0.5 µg/ml. The recovery rates of all spiked samples were >89% of the spiked value. OTC and TC were detected in muscle of fishes treated until the 3rd day of withdrawal period. The present study showed that the SPFIA can be easily adopted in predicting tissue residues for OTC and TC in farmed fishes. KEY WORDS: flounder, solid-phase fluorescence immunoassay, tetracycline antibiotics.

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Bioavailability of oxytetracycline in sea bass, Dicentrarchus labrax (L.)

Cited by 21 publications

References 23 publications

Antibacterial Drugs in Fish Farms: Application and Its Effects

Antibacterial Drugs in Fish Farms: Application and Its Effects

Antibacterial Agents in Mediterranean Finfish Farming: A Synopsis of Drug Pharmacokinetics in Important Euryhaline Fish Species and Possible Environmental Implications

Application of a Solid-Phase Fluorescence Immunoassay to Determine Oxytetracycline and Tetracycline Residues in Tissue of Olive Flounder (<i>Paralichthys olivaceus</i>)

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