Bioavailability of phenolic acids

Lafay, Sophie; Gil‐Izquierdo, Ángel

doi:10.1007/s11101-007-9077-x

Cited by 237 publications

(195 citation statements)

References 68 publications

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“…1.4 at a concentration of 5 mM were arbitrarily recognized as having a chemoattractant activity and were further examined at lower concentrations of 1 and 0.1 mM. This was based on the following data: preliminary control experiments showed a C i ¼ 2.4 ± 0.6 (n ¼ 10) for fMLP at a concentration 50-times lower (0.1 mM), additionally human plasma levels of the vast majority of phenolics tested in our experiments did not exceed 5 mM (Guy et al, 2009;Lafay & Gil-Izquierdo, 2008;Manach et al, 2005;Vitaglione et al, 2007).…”

Section: Chemotaxis Assaymentioning

confidence: 93%

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

Nowak

Zasowska-Nowak

Białasiewicz

et al. 2015

Pharmaceutical Biology

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Context: Polymorphonuclear leukocytes (PMNs) produce oxidants, contributing to systemic oxidative stress. Diets rich in plant polyphenols seem to decrease the risk of oxidative stressinduced disorders including cardiovascular disease. Objective: The objective of this study was to examine the in vitro effect of each of the 14 polyphenols on PMNs chemotaxis, intracellular calcium response, oxidants production. Materials and methods: Blood samples and PMNs suspensions were obtained from 60 healthy non-smoking donors and incubated with a selected polyphenol (0.5-10 mM) or a control solvent. We assessed resting and fMLP-dependent changes of intracellular calcium concentration ([Ca 2+ ] i ) in PMNs with the Fura-2AM method and measured fMLP-induced luminol enhanced whole blood chemiluminescence (fMLP-LBCL). Polyphenol chemoattractant activity for PMNs was tested with Boyden chambers. Results: Polyphenols had no effect on resting [Ca 2+ ] i . Unaffected by other compounds, fMLPdependent increase of [Ca 2+ ] i was inhibited by quercetin and catechol (5 mM) by 32 ± 14 and 12 ± 10% (p50.04), respectively. Seven of the 14 tested substances (5 mM) influenced fMLP-LBCL by decreasing it. Catechol, quercetin, and gallic acid acted most potently reducing fMLP-LBCL by 49 ± 5, 42 ± 15, and 28 ± 18% (p50.05), respectively. 3,4-Dihydroxyhydrocinnamic, 3,4-dihydroxyphenylacetic, 4-hydroxybenzoic acid, and catechin (5 mM) revealed distinct (p50.02) chemoattractant activity with a chemotactic index of 1.9 ± 0.8, 1.8 ± 0.7, 1.6 ± 0.6, 1.4 ± 0.2, respectively. Conclusion and discussion: Catechol, quercetin, and gallic acid at concentrations commensurate in human plasma strongly suppressed the oxidative response of PMNs. Regarding quercetin and catechol, this could result from an inhibition of [Ca 2+ ] i response.

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Section: Chemotaxis Assaymentioning

confidence: 93%

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

Nowak

Zasowska-Nowak

Białasiewicz

et al. 2015

Pharmaceutical Biology

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“…The modifications of phytochemicals occurring in humans after ingestion of food are of difficult evaluation (Lafay & Gil-Izquierdo, 2008): such a problem increases in the case of plant products that have to be cooked before consumption (RuizRodriguez, Marìn, Ocaña, & Soler-Rivas, 2008).…”

Section: Introductionmentioning

confidence: 99%

Cooking influence on physico-chemical fruit characteristics of eggplant (Solanum melongena L.)

et al. 2016

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“…Its derivatives include p-hydroxybenzoic, protocatechuic, vannilic, syringic and gallic acids. On the other hand, the hydroxycinnamic acids ( Figure 1B) are the largest class of phenolic compounds (Huang, Johanning & O'Dell, 1986;Herrmann, 1989), represented by caffeic, p-coumaric and ferulic acids ( Figure 1A) (Crozier, Jaganath & Clifford, 2009;Lafay & Gil-Izquierdo, 2008;Karakaya, 2004). Caffeic acid (CA) is the main hydroxycinnamic acid found in foods, mainly as chlorogenic acid (CGA).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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Hydroxycinnamic acid compounds are an important source of antioxidants due to their ubiquitous occurrence in the plant kingdom and their characteristic activities. Due to their antioxidant activity, several researchers have attributed a probable role of these compounds in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular diseases. Recent evidence suggests that these compounds may also act by other mechanisms in addition to the antioxidant capacity as modulating the activity of some specific enzymes and inhibit cell proliferation. This paper is a comprehensive review of the effects of hydroxycinnamic acids on cancer. The review encompasses the occurrence and bioavailability of these compounds evidences for their effects on cancer and the various mechanisms by which may exert their effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis; effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.

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Bioavailability of phenolic acids

Cited by 237 publications

References 68 publications

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

Cooking influence on physico-chemical fruit characteristics of eggplant (Solanum melongena L.)

Anticancer Properties of Hydroxycinnamic Acids -A Review

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