Bioavailability of resveratrol: Possibilities for enhancement

Vries, Konrad de; Strydom, Morné; Steenkamp, Vanessa

doi:10.1016/j.hermed.2017.09.002

Cited by 55 publications

(61 citation statements)

References 70 publications

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“…There are, however, comparatively fewer studies that investigated the effect of RE treatment and its consequent outcomes on cancer patients in vivo. The main limitation in such studies is poor bioavailability of RE when orally administered [191]. Indeed, despite the fact that in vitro studies showed promising results, a number of in vivo studies failed to attribute beneficial effects to RE [58,192].…”

Section: Resveratrol Impacts Cancer Onset: Clinical Studiesmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

437

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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Section: Resveratrol Impacts Cancer Onset: Clinical Studiesmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

437

293

View full text Add to dashboard Cite

show abstract

“…To improve the bioavailability of this compound, more complex formulations have been prepared, including nanoparticles and nanostructured lipid carriers containing resveratrol (Gokce et al, 2012;Peñalva et al, 2018). Enhancing resveratrol bioavailability was also attempted in rats by treating them with 3,5,4'-tri-O-acetylresveratrol (TARES), an acetylated resveratrol prodrug that can be enzymatically hydrolyzed to free trans-resveratrol in cells (de Vries et al, 2018).…”

Section: Anti-ageing Activitymentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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Resveratrol is a polyphenol which is abundant in grape skin and seeds. Sources of resveratrol in food also include wine, berries, and peanuts. This compound displays many properties including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, as well as aging. Due to the fact that resveratrol is generally well-tolerated, it is believed to be a promising compound in preventing many diseases such as diabetes and associated complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize recent information from in vitro and in vivo studies on animals and humans on the multiple effects of resveratrol on health and benefits of its intake.

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“…Various methodological approaches have been developed in recent years. These include several delivery systems such as the encapsulation of RES in lipid nanocarriers or liposomes, emulsions, micelles, insertion into polymeric nanoparticles, solid dispersions, and nanocrystals [59,60]. For example, the bioavailability of RES from the grapevine shoot extract Vineatrol30 has been significantly increased using a liquid micellar formulation, without any treatment-related adverse effects, making it a suitable system for improved supplementation [61].…”

Section: Bioavailability Of Resveratrol and Potential Side Effectsmentioning

confidence: 99%

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

et al. 2020

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Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

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Bioavailability of resveratrol: Possibilities for enhancement

Abstract: It is increasingly recognised that grape products have various potential health benefits and possible applications in a clinical setting (

Cited by 55 publications

References 70 publications

Potential Adverse Effects of Resveratrol: A Literature Review

Potential Adverse Effects of Resveratrol: A Literature Review

Health benefits of resveratrol administration

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

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