Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women

Zubik, Ligia; Meydani, Mohsen

doi:10.1093/ajcn/77.6.1459

Cited by 289 publications

(259 citation statements)

References 31 publications

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“…On the other hand, the decline in urinary isoflavone excretion levels could also result from a longer time period between urine collection and soy food consumption. For example, if soy foods were initially consumed in the evening and during later weeks in the morning, the overnight urine samples would contain fewer isoflavones due to the short half-life of these compounds (Franke et al, 1998a;Setchell et al, 2003;Zubik & Meydani, 2003). Furthermore, the declining trend of urinary isoflavone excretion levels might also reflect a decreasing bioavailability during continuous exposure (Lu et al, 1996).…”

Section: Soy Consumptionmentioning

confidence: 99%

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

et al. 2004

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Objective: To investigate the compliance of young girls with a soy intervention. Design: An 8-week dietary intervention and urine sample collection. Setting: Free-living girls. Subjects: A convenience sample of 8-to 14-y-old girls (20 started and 17 finished the study) recruited through flyers distributed to staff members and previous study participants. Intervention: The girls consumed one daily serving of soymilk, soy nuts, or tofu, completed 3-day food records, kept daily soy intake logs, and collected weekly urine samples. Main outcome measures: Compliance with the intervention was evaluated by daily soy intake logs, 3-day food records analyzed by the center's Food Composition and Food Groups Servings Databases, and weekly urinary isoflavone excretion using high-pressure liquid chromatography. The statistical analysis included paired t-tests, analysis of variance, and Spearman's rankorder correlation coefficients. Results: Daily soy intake logs indicated a mean intake of 6.28 servings out of a maximum of 7.0 servings per week. The food records revealed a six-fold increase in isoflavone intake during the study period (Po0.01) which was confirmed by an increase in urinary isoflavone excretion of similar magnitude (23.3-142.1 nmol/mg creatinine, P ¼ 0.02). Conclusions: This study demonstrated the ability of young girls to consume one daily soy serving and the usefulness of urinary isoflavones as a primary compliance measure. The high urinary isoflavone excretion levels detected in girls as compared to adult women suggest less intestinal degradation and/or greater absorption of isoflavones in nonadult populations. This finding requires further investigations into the pharmacokinetics of isoflavones.

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Section: Soy Consumptionmentioning

confidence: 99%

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

et al. 2004

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“…15) Study has also shown no difference in bioavailability between glycoside-form isoflavones and their aglycones. 16) Health effects of daidzin have been proved on memory impairment, hepatic failure, and glucose homeostasis. [17][18][19] It was also reported that glycitin has preventive effect on bone loss and osteonecrosis.…”

mentioning

confidence: 99%

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Zang

Igarashi

2015

Bioscience, Biotechnology, and Biochemistry

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“…Urinary isoflavonoid excretion shows the highest correlation with recent soy intake owing to the fast pharmacokinetics of isoflavonoids (Setchell et al, 2003;Zubik and Meydani, 2003). However, studies with large sample sizes that used validated diet questionnaires have consistently demonstrated significant associations in Asian and Western populations, even when urine was collected only once and soy intake was assessed over the previous year (Maskarinec et al, 1998;Seow et al, 1998;Chen et al, 1999;Atkinson et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii

et al. 2006

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Objective: To explore soy intake and urinary isoflavonoid excretion within several generations of American-Japanese women based on the hypothesis that earlier generations excrete higher levels of urinary isoflavonoids, in particular the metabolite equol, than later generations. Subjects: A convenience sample of 43 women from 19 families aged 18-78 years, all of whom reported at least 50% Japanese ancestry. Interventions: Each woman collected overnight urine samples at baseline and after consuming one serving of soymilk, both samples were analyzed for the isoflavonoids daidzein, genistein and equol using liquid chromatography-mass spectrometry. Results: Median isoflavone intakes during the last year were 7.2 mg/day for the first generation, 7.3 mg/day for the second generation and 6.3 mg/day for the third generation (P ¼ 0.36). At baseline, the median isoflavonoid excretion for the first generation was nonsignificantly higher than for later generations (190, 86 and 42 nmol/h; P ¼ 0.20) but after intervention, the median urinary isoflavonoid excretion was very similar for the three groups: 2465, 1895 and 2775 nmol/h (P ¼ 0.70). Following intervention, a nonsignificantly higher proportion of older than younger women (53 vs 32 and 33%; P ¼ 0.41) excreted the metabolite equol. The respective median equol excretion rates by generation following intervention were 39.5, 4.2 and 3.5 nmol/h (P ¼ 0.04). Conclusions: This small investigation among three generations of Japanese-Americans detected a higher equol production among older women after a soy challenge, but no difference in the excretion of total isoflavonoids after a standardized dose of soymilk was observed.

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Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women

Abstract: The apparent bioavailability of genistein and daidzein is not different when consumed as either aglycone or glucoside by American women.

Cited by 289 publications

References 31 publications

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii

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