Bioavailability of suckable tablets of oral N-acetylcysteine in man

Valserra, Mario De Bernardi Di; Mautone, Giuseppe; Barindelli, Edoardo; Lualdi, P; Feletti, Fausto; Galmozzi, M. R.

doi:10.1007/bf00558514

Cited by 11 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma concentrations of total cysteine and GSH were elevated after NAC ingestion. Previous pharmacokinetic studies suggest NAC plasma levels peak 45 min after oral administration 2, 5. This was not the case in our study.…”

Section: Discussioncontrasting

confidence: 61%

Effects of N‐acetylcysteine on glutathione oxidation and fatigue during handgrip exercise

et al. 2005

View full text Add to dashboard Cite

Fatigue of hand and forearm muscle groups can limit task performance by astronauts wearing space suits. Countermeasures to delay fatigue would therefore be useful to the space program. N-acetylcysteine (NAC) has been shown to inhibit fatigue during other tasks so we tested its effects during handgrip exercise. Volunteers practiced isometric handgrip maneuvers until performance was reproducible over three successive sessions (baseline). Performance then was retested after ingesting NAC (150 mg.kg(-1)) or saline. Drug administration increased NAC and cysteine blood levels (P < 0.001). Performance of sustained maximal efforts was unaffected. During repetitive submaximal efforts, NAC delayed fatigue (130% baseline) and inhibited glutathione oxidation. Saline did not alter glutathione status or performance of sustained maneuvers; repetitive task performance was increased by 15% (P < 0.05), a placebo effect. These data indicate that NAC supports glutathione homeostasis in exercising humans and may delay muscle fatigue during repetitive handgrip exercise. Our findings support oxidative stress as a causal factor in human muscle fatigue and argue for larger translational studies to define NAC effects on human performance.

show abstract

Section: Discussioncontrasting

confidence: 61%

Effects of N‐acetylcysteine on glutathione oxidation and fatigue during handgrip exercise

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Although N-acetyl-L-cysteine does not occur naturally, it is used as a drug ("Mucomyst") to reduce lung congestion (Friedman, 1973). The compound is an excellent nutritional source of cysteine for humans and animals (De Bernardi di Valserra et al, 1989;Friedman and Gumbmann, 1984), and acts as an antimutagen and anticarcinogen (De Flora et al, 1989;Friedman et al, 1982a;Stevens et al, 1995). Efforts are continuing to develop sulfite substitutes for browning prevention in potatoes and other foods.…”

Section: Dietary Significancementioning

confidence: 99%

Chemistry, Biochemistry, and Dietary Role of Potato Polyphenols. A Review

Friedman

1997

J. Agric. Food Chem.

511

352

View full text Add to dashboard Cite

Potatoes and other plant foods accumulate a variety of secondary metabolites, including phenolic compounds, phytoalexins, protease inhibitors, and glycoalkaloids, as a protection against adverse effects of mechanical bruising, light, and injury by predators including beetles, fungi, and insects. Since these phytochemicals are consumed by insects, animals, and humans as part of their normal diet, a need exists to develop a better understanding of the role of these compounds in both the plant and the diet. To contribute to this effort, this multidisciplinary overview describes analytical and compositional aspects of phenolic compounds in potatoes; their biosynthesis, molecular genetics, and role in host-plant resistance relationships; bruising-, ferrous ion-, and heat-induced discolorations such as after-cooking blackening and blackspot formation, which affect appearance and sensory properties of potatoes; polyphenol-oxidase-catalyzed enzymatic browning reactions and their prevention by chemical and plant molecular biology techniques; and effects of baking, cooking, microwaving, light, and γ-radiation on the stability of the major potato polyphenol, chlorogenic acid. Also covered are beneficial effects of phenolic compounds in the diet as antioxidants, antimutagens, anticarcinogens, antiglycemic, and hypocholesterolemic agents; adverse effects on protein nutritional quality; and recommendations for future research. Understanding the biochemical basis of stressinduced formation of polyphenols in plants, the chemistry of their transformations in the plant and in foods, and their functions in plant physiology, food science, nutrition, and health should stimulate interest in maximizing beneficial sensory, nutritional, and health effects of polyphenols in the diet. Such efforts should lead to better foods and improved human health.

show abstract

“…and Gumbmann, 1988) relpotency (%) Our studies revealed that IV-acetyl-L-cysteine is an excellent source of L-cysteine in vivo; i.e., the ability of the IV-acetyl derivative to substitute for L-methionine for mice turned out to be even better than that of L-cysteine itself Gumbmann, 1984, 1988). N-Acetyl-Lcysteine is also well-utilized by humans (De Bernardi di Valserra et al, 1989).…”

Section: Biological Utilization and Safety Of Sulfur Amino Acidsmentioning

confidence: 99%