Bioavailability of zinc from zinc-histidine complexes. I. Comparison with zinc sulfate in healthy men

Schölmerich, J; Freudemann, A; Köttgen, E.; Wietholtz, H.; Steiert, B; Löhle, E.; Häussinger, D; Gerok, W.

doi:10.1093/ajcn/45.6.1480

Cited by 69 publications

(40 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Los resultados del presente estudio pueden responder a una menor absorción intestinal del sulfato de zinc al ser administrado con leche, dada la interacción entre el zinc y el calcio descrita en algunos estudios (4,31), situación que pudo no haber ocurrido con el zinc aminoquelado debido a su estructura, la cual favoreció su absorción al no ser interferida por el calcio de la leche ni por otros micronutrientes del producto lácteo (17,18,32,33).…”

Section: Discussionunclassified

“…A pesar de su seguridad y baja toxicidad, estos compuestos pueden desencadenar efectos secundarios como náuseas, vómitos y dolor abdominal (15)(16)(17), sin mencionar su sabor desagradable, por lo que es necesario buscar vehículos que enmascaren su sabor para administrarlo a niños.…”

Section: Según El International Zinc Nutrition Consultativeunclassified

“…Existen escasos estudios con compuestos de zinc aminoquelado, los cuales muestran mayor absorción intestinal, mayor incremento en los niveles de zinc en sangre y mejor tolerancia digestiva (17,18); no se encontró información que estableciera cuál compuesto es más efectivo en niños preescolares.…”

Section: Según El International Zinc Nutrition Consultativeunclassified

See 2 more Smart Citations

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

Sánchez¹,

Villada²,

Rojas³

et al. 2013

biomedica

View full text Add to dashboard Cite

Biomédica 2014;34:79-91 El zinc en la incidencia de la infección respiratoria y la diarrea Contribución de los autores:Juliana Sánchez y Oscar Villada: análisis estadístico, interpretación de los resultados y redacción del manuscrito. Liliana Patricia Montoya, Ana Milena Herrera, Maylen Liseth Rojas, Alejandro Díaz, Javier Chica y Cristian Vargas: análisis de los resultados. Todos los autores participaron en el diseño y ejecución del estudio, la revisión y la aprobación de la versión final del manuscrito Introducción. El déficit de zinc es común en niños de poblaciones en desarrollo. La deficiencia de zinc altera el sistema inmunológico y la resistencia a las infecciones. Objetivo. Evaluar el efecto de dos compuestos de zinc en la prevención de la infección respiratoria y la diarrea agudas. Materiales y métodos. Se llevó a cabo un ensayo comunitario triple ciego en 301 niños entre dos y cinco años de edad de centros infantiles de Medellín. Fueron seis conglomerados distribuidos aleatoriamente en tres grupos de intervención que recibieron zinc aminoquelado, sulfato de zinc y placebo durante cinco días de la semana a lo largo de 16 semanas. Se evaluaron diariamente los síntomas de infección respiratoria, diarrea aguda y efectos secundarios.Resultados. La incidencia de la infección respiratoria fue menor con el zinc aminoquelado (1,42 por 1.000 días-niño) comparado con el sulfato de zinc (1,57 por 1.000 días-niño) (RR=0,90, IC 95% : 0,382 a 2,153, p=0,999) y con el placebo (3,3 por 1.000 días-niño) (RR=0,43, IC 95% : 0,196 a 0,950, p=0,049). La incidencia de diarrea aguda con el zinc aminoquelado (0,15 por 1.000 días-niño) fue menor que con el sulfato de zinc (1,18 0,78 por 1.000 días-niño) (RR=0,20, IC 95% : 0,0043 a 1,662, p=0,361) y que la del grupo placebo (0,49 por 1.000 días-niño) (RR=0,32, IC 95% : 0,006 a 3,990, p=0,346). Conclusiones. El zinc aminoquelado tuvo mejor efecto en la disminución de la incidencia de la infección respiratoria y la diarrea agudas en niños preescolares comparado con los otros grupos de estudio. Effect of zinc amino acid chelate and zinc sulfate in the incidence of respiratory infection and diarrhea among preschool children in child daycare centers Introduction: Zinc deficiency is common in children among populations in developing areas. Zinc deficiency alters the immune system and the resistance to infections. Objective: To evaluate the effect of two zinc compounds in the prevention of acute respiratory infection and acute diarrhea. Materials and methods: Randomized triple-blind community trial with 301 children between 2-5 years of age from six child daycare centers in Medellin, Colombia. Children were distributed in three groups receiving zinc amino acid chelate, zinc sulfate and placebo five days a week for 16 weeks. Daily symptoms of respiratory infection, acute diarrhea and side effects were evaluated. Results: The incidence of respiratory infection was lower with zinc amino acid chelate (1.42 per 1,000 child-days) compared with placebo (3.3 per 1,000 child-days) (RR=0.43, ...

show abstract

Section: Discussionunclassified

Section: Según El International Zinc Nutrition Consultativeunclassified

See 1 more Smart Citation

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

Sánchez¹,

Villada²,

Rojas³

et al. 2013

biomedica

View full text Add to dashboard Cite

show abstract

“…13 sulfate, acetate, carbonate or oxide. 22,23 The solubility of these zinc salts in aqueous solution is variable; zinc carbonate and oxide are basically insoluble, having a much lower absorption. 24 In the present study, we used zinc bis-histidinate chelate, which consists of zinc bound to two histidine molecules as chelate.…”

Section: Discussionmentioning

confidence: 99%

Suplementação com zinco pode recuperar apetite para refeições de sal

Campos¹,

Neto²,

Filho³

et al. 2004

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: To evaluate the effect of zinc on the appetite for salt foods in children aged 8 months to 5 years.Method: Double-blind, placebo-controlled study. Two groups of 20 children refusing to eat salt foods were followed during six months. The children in the first group received zinc chelate 1 mg/kg daily for three months. The second group received a placebo solution. The two groups were similar in terms of age, sex, weight, duration of breastfeeding, age at weaning, biochemical and hematological data. The response of children to treatment was informed by their mothers.Results: 17/20 (85%) of the children receiving zinc chelate and 10/20 (50%) of the children receiving placebo improved their appetite for salt foods. The difference was statistically significant (p < 0.05, chi-square test).Conclusion : Zinc supplementation may improve the acceptance of salt foods by children.J Pediatr (Rio J). 2004;80(1):55-9: Zinc and appetite, appetite for salt foods, zinc chelate, anorexia in children.

show abstract

“…Urinary excretion was not different with any preparation. Application of 15 mg zinc as zinc histidine complex (1:2) gave an identical serum response as 45 mg zinc sulphate suggesting that the zinc histidine complex was better absorbed and subsequently, more bioavailable than zinc sulphate (Schölmerich et al, 1987).…”

Section: Zinc Bisglycinatementioning

confidence: 95%

Opinion on certain bisglycinates as sources of copper, zinc, calcium, magnesium and glycinate nicotinate as source of chromium in foods intended for the general population (including food supplements) and foods for particular nutritional uses - Scientific

Authority¹

2008

EFSA Journal

View full text Add to dashboard Cite

SUMMARYFollowing a request from the European Commission, the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) was asked to deliver a scientific opinion on the use of copper bisglycinate chelate and chromium glycinate nicotinate as sources for respectively copper and chromium added for nutritional purposes to food supplements, and of calcium bisglycinate chelate and magnesium bisglycinate chelate as sources for respectively calcium and magnesium added for nutritional purposes to foods for particular nutritional uses and food supplements, and of zinc bisglycinate chelate when used as a source for zinc in foods intended for the general population (including food supplements) and foods for particular nutritional uses.The mineral amino acid chelates considered in this application are intended for use as a direct replacement for the permitted respective mineral forms of copper and chromium for nutritional purposes in food supplements according Council Directive 2002/46/EC, for calcium and magnesium for nutritional purposes in food supplements and the categories of PARNUTS other than for baby foods and infant formula according to Council Directive 89/398/EEC, and for zinc in foods intended for the general population (including food supplements) and foods for particular nutritional uses. The present opinion deals only with the safety of bisglycinate chelates of copper, zinc, calcium, magnesium, and of glycinate nicotinate as sources of the nutrient cations of respectively copper, zinc, calcium, magnesium and chromium and with the bioavailability of the nutrient cations from these sources. The safety of the nutrient cations themselves (copper, chromium, zinc, calcium and magnesium), in terms of amounts that may be consumed, is outside the remit of this Panel.The bisglycinates considered in this opinion consist of a bivalent metal ion, namely Cu +2 , Zn +2 , Ca +2 , and Mg +2 , linked to two molecules of glycine. The metal is bound to the carboxyl group and to the α-amino group of glycine with coordinate covalent bonds to form two heterocyclic rings. This 1:2 metal to ligand ratio restricts reaction with dietary inhibitors of the metal absorption and does not participate in oxidation reactions.Chromium(III) glycinate nicotinate chelate is also considered in this opinion.No specific use levels for the mineral bisglycinates under consideration in this opinion have been given. However, it is assumed that under the intended conditions of use, the daily intake would not exceed those levels anticipated through existing supplementation of the listed minerals and would be similar to other forms of copper, zinc, calcium, magnesium and chromium that are already approved for use in foods in the EU.Regarding the bioavailability of the different cations from their sources, data are provided showing that the minerals are bioavailable after oral administration.No genetic toxicity studies have been conducted on the compounds; however the Panel has no concern on the genotoxicity aspects of gly...

show abstract

Bioavailability of zinc from zinc-histidine complexes. I. Comparison with zinc sulfate in healthy men

Cited by 69 publications

References 33 publications

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

Efecto del zinc aminoquelado y el sulfato de zinc en la incidencia de la infección respiratoria y la diarrea en niños preescolares de centros infantiles

Suplementação com zinco pode recuperar apetite para refeições de sal

Opinion on certain bisglycinates as sources of copper, zinc, calcium, magnesium and glycinate nicotinate as source of chromium in foods intended for the general population (including food supplements) and foods for particular nutritional uses - Scientific

Contact Info

Product

Resources

About