2019
DOI: 10.20944/preprints201901.0116.v1
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Bioavailable menthol (Transient Receptor Potential Melastatin-8 agonist) induces energy expending phenotype in differentiating adipocytes

Abstract: Recent evidences support a role of menthol, a TRPM8 agonist, in enhanced energy expenditure, thermogenesis and BAT-like activity in classical WAT depots in TRPM8 dependent and independent manner. The present study was designed to analyze whether oral and topical administration of menthol is bioavailable at subcutaneous adipose tissue and is sufficient to induce desired energy expenditure effects directly. GC-FID was performed to study menthol bioavailability in serum and subcutaneous white adipose tissue follo… Show more

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