Biobanking for Epidemiological Research and Public Health

Brand, Angela; Probst‐Hensch, Nicole

doi:10.1159/000104450

Cited by 32 publications

(28 citation statements)

References 105 publications

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“…Proponents argue that biobank-based research is an important means for further understanding the multifactorial nature of genetic and environmental factors in causing common disease. Researchers hope that the genomic knowledge gleaned from such biobanks will enable a better understanding of the role of genetics in disease [3] as well as lead to a more personalized approach to medicine with safer and more effective drug use by permitting individualized therapy (i.e. pharmacogenomics) [4].…”

Section: Biobanks – Promises and Problemsmentioning

confidence: 99%

Structuring Public Engagement for Effective Input in Policy Development on Human Tissue Biobanking

O’Doherty

Hawkins²

2010

Public Health Genomics

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We begin with the premise that human tissue biobanking is associated with ethical ambiguities and regulatory uncertainty, and that public engagement is at least one important element in addressing such challenges. One is then confronted with how to achieve public engagement that is both meaningful and effective. In particular, how can public engagement on the topic of biobanking be implemented so that (a) it is perceived broadly as legitimate and (b) the results of the engagement are relevant and useful to the institutional and regulatory context? In this paper we build on previous work that has addressed the former point and focus primarily on the latter. We argue that one way to increase the likelihood of results of public engagement being taken up in policy is through framing the issues that are deliberated by members of the public based in part on the practical policy questions for which input is sought. In this approach, we move discussion on the social and ethical implications of biobanking from abstract principles, to their consideration in the context of local biobanking practices. This is illustrated using a practical example involving a public engagement conducted to inform institutional policy for biobanking in British Columbia, Canada.

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Section: Biobanks – Promises and Problemsmentioning

confidence: 99%

Structuring Public Engagement for Effective Input in Policy Development on Human Tissue Biobanking

O’Doherty

Hawkins²

2010

Public Health Genomics

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“…Biobanking encompasses a wide range of specimen types and sample collection designs, ranging from population-based biobanking of specimens from healthy subjects in large, epidemiological cohorts to specific biobanking of diseased tissues obtained in the course of clinical interventions [2, 5–7]. Human tissue biobanking is of particular importance for implementation of novel biomarkers into clinical trials, as well as for the application of a wide range of new technologies (-“omics”) to the discovery and validation of new, molecular patterns of disease [8–12].…”

Section: Introductionmentioning

confidence: 99%

The role of the pathologist in tissue banking: European Consensus Expert Group Report

Bevilacqua

Bosman²,

Dassesse

et al. 2010

Virchows Arch

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Human tissue biobanking encompasses a wide range of activities and study designs and is critical for application of a wide range of new technologies (-“omics”) to the discovery of molecular patterns of disease and for implementation of novel biomarkers into clinical trials. Pathology is the cornerstone of hospital-based tissue biobanking. Pathologists not only provide essential information identifying the specimen but also make decisions on what should be biobanked, making sure that the timing of all operations is consistent with both the requirements of clinical diagnosis and the optimal preservation of biological products. This document summarizes the conclusions of a Pathology Expert Group Meeting within the European Biological and Biomolecular Research Infrastructure (BBMRI) Program. These recommendations are aimed at providing guidance for pathologists as well as for institutions hosting biobanks on how to better integrate and support pathological activities within the framework of biobanks that fulfill international standards.

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“…[7]. To date, biobanking and public health surveillance have been looked at independently from each other [8]. In fact, the assimilation of genomics into the public health response to conditions like ‘cancer clusters, outbreaks of infectious diseases [...] [and] effects of toxic exposure, or adverse events following vaccination’ [9] remains a great challenge.…”

Section: Introductionmentioning

confidence: 99%

Framing Genomics, Public Health Research and Policy: Points to Consider

Knoppers

Leroux²,

Doucet³

et al. 2010

Public Health Genomics

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Genetic information can be used to target interventions that improve health and prevent disease. Indeed, the results of population genomics research could be useful for public health and national pandemic plans. Yet, firm scientific evidence originating from such research and the indicators of the role of health determinants, gene-gene and gene-environment interaction remain to be assessed and validated before being integrated into pandemic plans or public health programmes. It is not clear what is the role of the State in research on the elucidation of the determinants of gene-gene and gene-environment interactions and how, when, and if such data can be accessed and used for such planning. Over a period of 3 years, we sought to address these questions by gathering data and literature relevant to research in public health genomics, preparing issues papers and, finally, consulting with stakeholders on a provisional ‘points to consider’ document at various times. Examining in turn the issues of privacy, State powers, stakeholder perceptions, and public participation, we propose in this article, for each of these themes, a series of recommendations aiming to provide guidance on the role of the State in the use of genomic information for public health research, prevention and planning.

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Biobanking for Epidemiological Research and Public Health

Cited by 32 publications

References 105 publications

Structuring Public Engagement for Effective Input in Policy Development on Human Tissue Biobanking

Structuring Public Engagement for Effective Input in Policy Development on Human Tissue Biobanking

The role of the pathologist in tissue banking: European Consensus Expert Group Report

Framing Genomics, Public Health Research and Policy: Points to Consider

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