Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

“…However, the percentage release of ibuprofen did not exceed 50% at pH 7.4 and did not exceed 70% at pH 2.0. In contrast to [ 102 ], in [ 103 ], the percentage of ibuprofen release from a porous hydrogel based on a copolymer of N-isopropylacrylamide and crotonic acid was more than 50% at pH 6.8, but not more than 11% in a 0.1 M HCl solution.…”

Preparation and characterization of PA/P(AA-co-AM) composite hydrogels via photopolymerization

“…4 In the medical eld, hydrogels can be used as a drug carrier to deliver drugs to specic locations in the human body, improving drug safety and efficacy. [5][6][7] In the eld of environmental protection, hydrogels can be used to absorb organic matter and heavy metal ions in wastewater, improving water quality. 8,9 However, the widespread application of most hydrogels is seriously limited due to their poor fatigue resistance and conductivity.…”

Physicochemical Properties of Temperature-/pH-Sensitive Hydrogel Materials

“…Hydrogel materials are commonly composed of natural polymers like collagen, gelatin, or cellulose, forming three-dimensional networks of hydrophilic polymer chains capable of absorbing substantial fluids, water, or bodily fluids. The structure and properties of hydrogel materials can be tailored through the selection of appropriate biomaterials, cross-linking methodologies, and fabrication techniques [4][5][6].…”