Biobased Thermoplastic Polyurethanes and Their Capability to Biodegradation

Alhanish, Atika; Ghalia, Mustafa Abu

doi:10.1007/978-981-33-4749-6_4

Cited by 10 publications

(6 citation statements)

References 60 publications

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“…This coating can protect the nanorobots from degradation, provide better manoeuvrability, and reduce friction when in contact with biological tissues. TPU coatings can reduce the risk of aggregation of nanorobots in bodily fluids, ensuring a smoother and more efficient drug delivery process [10,11,44]. It can be incorporated into the 4D printing process to create components with shapechanging capabilities in response to external stimuli, improving the nanorobots' ability to reach target locations and release drugs as needed.…”

Section: Overcoming the Limitations Of Endogenous And Exogenous Power...mentioning

confidence: 99%

“…Its versatility and compatibility with various drug formulations make it a popular choice for encapsulating and delivering therapeutic agents. On the other hand, TPU is another biocompatible polymer known for its flexibility and durability which can be used to create flexible components or coatings for nanorobots/microbots, allowing for improved mobility and adaptability within the body's complex environment [10]. TPU-coated nanorobots can navigate tight spaces, overcome obstacles, and potentially target specific tissues or cells more effectively.…”

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confidence: 99%

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Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review

Das,

Sultana

2024

Futur J Pharm Sci

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Background Drug delivery systems (DDSs) encompass a wide range of methods, including oral, injectable, and topical routes of administration, all tailored to meet specific patient needs. Micro and nanorobots, equipped with pioneering propulsion mechanisms that convert external energy sources into precise movements, have revolutionized drug delivery. This cutting-edge technology ensures highly efficient drug delivery, particularly when targeting specific targets within intricate physiological environments. In contrast to traditional drug delivery approaches that rely on bloodstream circulation, engineered micro/nanorobots have autonomous mobility, enabling drug delivery to previously unreachable areas. Main body of the abstract Integrating micro/nanorobots into drug delivery raises vital safety and biocompatibility issues. These encompass material selection, degradation in-vivo, overcoming biological barriers, controlled movement, external interference, immune response, chemical reactions, systemic effects, long-term impact, and real-time monitoring. While micro/nanorobots hold immense transformative potential, they confront significant hurdles in their journey toward practical applications. Chief among these challenges are concerns regarding biocompatibility, ensuring that these tiny devices do not trigger adverse reactions. Long-term safety remains a critical issue, as understanding the effects of prolonged exposure and potential accumulations within the body and navigating complex biological environments with precision is another obstacle. Short conclusion The paper summarizes how to explore the various ways in which micro/nanorobots can be employed to enhance drug delivery, including their precision, targeting capabilities, and adaptability to different physiological conditions. Additionally, the review seeks to highlight the transformative potential of these technologies and their impact on the pharmaceutical industry.

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Section: Overcoming the Limitations Of Endogenous And Exogenous Power...mentioning

confidence: 99%

mentioning

confidence: 99%

Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review

Das,

Sultana

2024

Futur J Pharm Sci

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“…Nevertheless, according to CO 2 generation, at least 5% of the TPU was biodegraded during the period of testing, which indicates that perhaps over a longer period, these blends could biodegraded. Bearing in mind the successful results obtained in improving the mechanical performance of PHBV, it would then be of great interest to explore the replacement of this TPU with some new generation bioelastomers that would not compromise biodegradability [65,66], or use special additives to promote the biodegradability of TPUs.…”

Section: Biodegradationmentioning

confidence: 99%

In Service Performance of Toughened PHBV/TPU Blends Obtained by Reactive Extrusion for Injected Parts

et al. 2022

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Moving toward a more sustainable production model based on a circular economy, biopolymers are considered as one of the most promising alternatives to reduce the dependence on oil-based plastics. Polyhydroxybutyrate-co-valerate (PHBV), a bacterial biopolyester from the polyhydroxialkanoates (PHAs) family, seems to be an attractive candidate to replace commodities in many applications such as rigid packaging, among others, due to its excellent overall physicochemical and mechanical properties. However, it presents a relatively poor thermal stability, low toughness and ductility, thus limiting its applicability with respect to other polymers such as polypropylene (PP). To improve the performance of PHBV, reactive blending with an elastomer seems to be a proper cost-effective strategy that would lead to increased ductility and toughness by rubber toughening mechanisms. Hence, the objective of this work was the development and characterization of toughness-improved blends of PHBV with thermoplastic polyurethane (TPU) using hexamethylene diisocyanate (HMDI) as a reactive extrusion agent. To better understand the role of the elastomer and the compatibilizer, the morphological, rheological, thermal, and mechanical behavior of the blends were investigated. To explore the in-service performance of the blends, mechanical and long-term creep characterization were conducted at three different temperatures (−20, 23, 50 °C). Furthermore, the biodegradability in composting conditions has also been tested. The results showed that HMDI proved its efficiency as a compatibilizer in this system, reducing the average particle size of the TPU disperse phase and enhancing the adhesion between the PHBV matrix and TPU elastomer. Although the sole incorporation of the TPU leads to slight improvements in toughness, the compatibilizer plays a key role in improving the overall performance of the blends, leading to a clear improvement in toughness and long-term behavior.

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“…Polymeric materials are commonly used for scaffold fabrication in BTE due to their excellent formability, biocompatibility, and tunable mechanical strength [ 7 , 8 ]. Several biocompatible polymeric materials, such as polycaprolactone (PCL) [ 9 , 10 , 11 , 12 ], polylactic acid (PLA) [ 13 , 14 , 15 ], polyglycolic acid (PGA) [ 13 , 16 , 17 ], polyurethane (PU) [ 18 ], and polyether ketone (PEEK) [ 19 ], have been extensively studied and employed for the production of scaffolds. PCL, a synthetic and biodegradable polymer, has gained approval from both the U.S. Food and Drug Administration and the European Medicines Agency for its applications in healthcare.…”

Section: Introductionmentioning

confidence: 99%

Development of Hydroxyapatite/Polycaprolactone Composite Biomaterials for Laser Powder Bed Fusion: Evaluation of Powder Characteristics, Mechanical Properties and Biocompatibility

Yao,

Zhu,

Zhu

et al. 2024

Polymers

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Hydroxyapatite/polycaprolactone (HA/PCL) composites have been extensively explored in laser powder bed fusion (L-PBF) for bone tissue engineering. However, conventional mechanical mixing methods for preparing composite powders often yield inhomogeneous compositions and suboptimal flowability. In this study, HA/PCL powders were prepared and optimized for L-PBF using the modified emulsion solvent evaporation method. The morphology, flowability and thermal and rheological properties of the powders were systematically investigated, along with the mechanical and biological properties of the fabricated specimens. The HA/PCL powders exhibited spherical morphologies with a homogeneous distribution of HA within the particles. The addition of small amounts of HA (5 wt% and 10 wt%) enhanced the processability and increased the maximum values of the elastic modulus and yield strength of the specimens from 129.8 MPa to 166.2 MPa and 20.2 MPa to 25.1 MPa, respectively, while also improving their biocompatibility. However, excessive addition resulted in compromised sinterability, thereby affecting both mechanical and biological properties.

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Biobased Thermoplastic Polyurethanes and Their Capability to Biodegradation

Cited by 10 publications

References 60 publications

Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review

Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review

In Service Performance of Toughened PHBV/TPU Blends Obtained by Reactive Extrusion for Injected Parts

Development of Hydroxyapatite/Polycaprolactone Composite Biomaterials for Laser Powder Bed Fusion: Evaluation of Powder Characteristics, Mechanical Properties and Biocompatibility

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