Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity.

Suarez, Edward C.; Williams, Robert B.; Toralles, Ricardo Peraça; Zimmerman, Elise; Schanberg, S M

doi:10.1097/00006842-199109000-00004

Cited by 66 publications

(12 citation statements)

References 26 publications

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“…Subsequent research has strongly suggested that sympathetic nervous system (SNS)-mediated hyperresponsivity to behavioral stressors is associated with elevations in serum lipids. One study by Suarez et al (1991) showed greater catecholaminergic (i.e., epinephrine and norepinephrine) responses among men exhibiting Type A hostility as opposed to Type B (low-hostility) responders. For both human and animal populations SNS excitation, in the form of an increase in circulating catecholamine, has been implicated in the elevation of cholesterol levels (Jorgensen et aL, 1988).…”

Section: Discussionmentioning

confidence: 99%

Serum cholesterol and aggression in hospitalized male forensic patients

Hillbrand

Spitz

Foster³

1995

J Behav Med

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Human studies of the link between serum cholesterol and aggression have yielded equivocal results. Depending on the type of aggression studied (e.g., criminal violence or Type A hostility), investigators have found either a negative or a positive association between cholesterol and aggressive behavior. We conducted a retrospective analysis of aggressive incidents in a sample of hospitalized male forensic patients. The whole sample had lower cholesterol levels than the general population. Patients with low cholesterol levels (< 200 mg/dl) engaged in more frequent aggressive behavior but showed no difference in severity of aggression. They also showed no difference in verbal vs physical aggression. The relationship between cholesterol and frequency of aggression was curvilinear, with the most frequent acts of aggression committed by patients with moderately low cholesterol levels. Current research findings regarding the cholesterol-aggression association suggest the need for further clarification of the behavioral parameters under investigation.

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Section: Discussionmentioning

confidence: 99%

Serum cholesterol and aggression in hospitalized male forensic patients

Hillbrand

Spitz

Foster³

1995

J Behav Med

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“…The slower stress recovery of blood type O people would decrease the amount of TxPA available to protect them from the injurious effects of VLDL after stress or emotional upset relative to blood type A individuals. Several CAD risk factors such as total serum cholesterol and blood viscosity have also been correlated with acute stress response and emotional traits/behavior patterns (7,24,25). It is unknown how TxPA correlates with these and many other CAD risk factors.…”

Section: Discussionmentioning

confidence: 99%

Effects of stress and blood type on cortisol and VLDL toxicity preventing activity.

Neumann¹,

Arbogast²,

David³

et al. 1992

Psychosomatic Medicine

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Past research has associated ABO blood type and mental stress with cardiovascular risk. We studied the effects of blood type (A vs. O) coupled with a mirror drawing stressor on very low density lipoprotein toxicity-preventing activity (TxPA) and plasma cortisol levels. Exposure to the stressor significantly decreased TxPA and increased cortisol for the total group of 25 older adult males. However, the stress response patterns of the 15 blood type A males were different from those of the 10 type O subjects. The blood type A group had higher initial levels of TxPA and cortisol as well as quicker stress recovery rates than the type O group. ABO blood type may be an important behavioral hematologic variable to assess in studies concerning biochemical stress response or cardiovascular risk.

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“…Anger states can also elevate catecholamine levels transiently [51], but it is unclear whether such increases are sustained over time or occur more frequently in persons with high trait anger scores, high anger expression, or high anger inhibition. It is also unclear whether increases in catecholamines due to anger states can actually lead to hypertension.…”

Section: Biological Plausibility Issuesmentioning

confidence: 99%

Psychologic factors as precursors to hypertension

Markovitz

Jonas

Davidson

2001

Current Science Inc

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The possibility that certain psychologic factors lead to hypertension has been considered by many investigators over the past 60 years, but prospective studies with suitable methods to evaluate this hypothesis were not available for analysis until the 1990s. There are now five large longitudinal studies demonstrating a relation between symptoms of anxiety or depression and subsequent hypertension incidence. Anger expression, long considered a major psychologic factor in hypertension, has been studied less extensively, and the findings to date are less consistent. While some evidence supports the biological plausibility of psychologic factors as risk factors for hypertension, biobehavioral mechanisms explaining the relationship have not been adequately explored. The results of these recent studies may lead to new intervention trials specifically selecting hypertensive patients with anxiety or depression for treatment with stress reduction or other appropriate psychologic therapies. Such studies would further contribute to the evaluation of anxiety and depression as risk factors for hypertension.

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Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity.

Cited by 66 publications

References 26 publications

Serum cholesterol and aggression in hospitalized male forensic patients

Serum cholesterol and aggression in hospitalized male forensic patients

Effects of stress and blood type on cortisol and VLDL toxicity preventing activity.

Psychologic factors as precursors to hypertension

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