Biobehavioral Factors and Cancer Progression

Lutgendorf, Susan K.; Sood, Anil K.

doi:10.1097/psy.0b013e318235be76

Cited by 164 publications

(76 citation statements)

References 102 publications

(90 reference statements)

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“…45,46 In this pilot study, although other cytokines characterizing different T helper classes were evaluated, there were no significant associations with cohort or questionnaire data, possibly due to limitations of sample size and methodology. Future studies will require more stringent confirmation of biospecimen collection that should be prospective and longitudinal, thereby limiting the need for use of archived biospecimens.…”

Section: Discussionmentioning

confidence: 66%

Biopsychological Stress Factors in BRCA Mutation Carriers

et al. 2012

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Objective Cancer risk-related stressors are prominent among BRCA mutation carriers. Loss of one’s mother to a BRCA-associated cancer is an additional stressor, which may be related to an enhanced inflammatory response. This study examined the effect of mother’s vital status on psychological factors and stress-associated biomarkers among BRCA mutation carriers. The role of bereavement on biopsychological variables was also examined. Methods BRCA-carriers with known maternal transmission enrolled in the Gilda Radner Hereditary Cancer Program were invited to participate. Focus group composition was predetermined based on participants’ personal cancer history and mother’s vital status. Prior to the focus group, participants completed a Quality of Life (QOL) survey and collected a first morning saliva sample. Inflammatory biomarkers were analyzed from proximal archived serum. One day post focus group, a process survey, and morning saliva were collected. Results QOL was significantly lower for those whose mothers are deceased (n = 17) compared to those whose mothers are alive (n = 15) (P = 0.003) after adjusting for age, personal cancer history and prophylactic surgery. Similarly, those whose mothers are deceased reported significantly more perceived stress (P = 0.015), more intrusive thoughts related to cancer risk (P = 0.049), and more anxiety (P = 0.003). Higher bereavement scores were significantly associated with QOL and psychological measures. Biomarker correlates were consistent with and significantly correlated to the patient-reported psychological outcomes for those whose mothers were deceased. Conclusions BRCA mutation carriers with a known maternal transmission whose mother is deceased report higher perceived stress and anxiety, lower QOL, and a stress-associated biomarker profile that is potentially globally immune suppressive.

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Section: Discussionmentioning

confidence: 66%

Biopsychological Stress Factors in BRCA Mutation Carriers

et al. 2012

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“…Stress can have extensive physiologic effects [10], including telomere shortening, increased inflammatory cytokines and decreased cell-mediated immunity, which are associated with increased cancer risk and poorer cancer-related outcomes [4, 11-13]. Although stress may not directly cause cancer, it can promote cancer growth and progression through neuroendocrine pathways (e.g., sympathetic nervous system, hypothalamic-pituitary-adrenal axis) that increase inflammation, promote angiogenesis, reduce anoikis, and decrease the efficacy of chemotherapy [4, 6, 14].…”

Section: Psychophysiological Rationale For the Use Of Yoga During Canmentioning

confidence: 99%

“…Although stress may not directly cause cancer, it can promote cancer growth and progression through neuroendocrine pathways (e.g., sympathetic nervous system, hypothalamic-pituitary-adrenal axis) that increase inflammation, promote angiogenesis, reduce anoikis, and decrease the efficacy of chemotherapy [4, 6, 14]. Biobehavioral interventions such as yoga therefore have the potential to improve cancer outcomes by decreasing stress and disrupting its effects on cancer biology [4, 11, 15]. …”

Section: Psychophysiological Rationale For the Use Of Yoga During Canmentioning

confidence: 99%

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Review of yoga therapy during cancer treatment

Danhauer

Addington

Sohl

et al. 2017

Support Care Cancer

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Purpose Reviews of yoga research that distinguish results of trials conducted during (versus after) cancer treatment are needed to guide future research and clinical practice. We therefore conducted a review of non-randomized studies and randomized controlled trials of yoga interventions for children and adults undergoing treatment for any cancer type. Methods Studies were identified via research databases and reference lists. Inclusion criteria: (1) children or adults undergoing cancer treatment; (2) intervention stated as yoga or component of yoga; and (3) publication in English in peer-reviewed journals through October 2015. Exclusion criteria: (1) samples receiving hormone therapy only; (2) interventions involving only meditation; and (3) yoga delivered within broader cancer recovery or mindfulness-based stress reduction programs. Results Results of non-randomized (adult: n=8, pediatric: n=4) and randomized controlled trials (adult: n=13, pediatric: n=0) conducted during cancer treatment are summarized separately by age group. Findings most consistently support improvement in psychological outcomes (e.g., depression, distress, anxiety). Several studies also found that yoga enhanced quality of life, though further investigation is needed to clarify domain-specific efficacy (e.g., physical, social, cancer-specific). Regarding physical and biomedical outcomes, evidence increasingly suggests that yoga ameliorates sleep and fatigue; additional research is needed to advance preliminary findings for other treatment sequelae and stress/immunity biomarkers. Conclusions Among adults undergoing cancer treatment, evidence supports recommending yoga for improving psychological outcomes, with potential for also improving physical symptoms. Evidence is insufficient to evaluate the efficacy of yoga in pediatric oncology. We describe suggestions for strengthening yoga research methodology to inform clinical practice guidelines.

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“…The presence of cancer-related symptoms, painful treatments, diminished quality of life, disease recurrence or progression, and uncertain mortality all contribute to patients’ experience of anxiety and depression (Jacobsen & Jim, 2008). Anxiety and depression in cancer patients are associated with sleep disturbance, loss of appetite (Trask, 2004), heightened expectancy of pain (Velikova, Selby, Snaith, & Kirby, 1995), poor adherence with recommended therapy (DiMatteo, Lepper, & Croghan, 2000), tumor progression (Lutgendorf & Sood, 2011), and mortality (Giese-Davis et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Anxiety and Depression Among Cancer Survivors: The Role of Engagement With Sources of Emotional Support Information

Mello

Tan

Armstrong

et al. 2013

Health Communication

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This study explores cancer survivors’ engagement with information about emotional support from doctors, interpersonal sources, and the media and examines to what extent such engagement affects subsequent self-reported anxiety and depression. Patients with colorectal, breast, or prostate cancer (n=1,128) were surveyed over three years following diagnosis. Using lagged logistic regression, we predicted the odds of experiencing anxiety or depression based on earlier engagement with sources of emotional support, adjusting for prior symptoms and confounders. Among those reporting anxiety or depression (n=476), we also asked whether information engagement affected the severity of those symptoms. Participants obtained information about emotional support from multiple sources, but most often from physicians. Discussions with physicians about emotional support increased the odds of cancer survivors subsequently reporting anxiety or depression by 1.58 times (95% CI: 1.06 to 2.35; p=0.025), adjusted for prior symptoms and confounders. Scanning from media sources was also significantly associated with increased odds of reporting emotional symptoms (OR=1.72; 95% CI: 1.03 to 2.87; p=0.039). However, among those who reported symptoms, doctor-patient engagement predicted slightly reduced interference of these symptoms with daily activities (B=−0.198; 95% CI: −0.393 to −0.003; p=0.047). Important implications for health communication research and practice are discussed.

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Biobehavioral Factors and Cancer Progression

Cited by 164 publications

References 102 publications

Biopsychological Stress Factors in BRCA Mutation Carriers

Biopsychological Stress Factors in BRCA Mutation Carriers

Review of yoga therapy during cancer treatment

Anxiety and Depression Among Cancer Survivors: The Role of Engagement With Sources of Emotional Support Information

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