BioCAST : le Bio-observatoire national du cancer bronchiques chez les patients non fumeurs (IFCT1002)

Couraud, S.; Labonne, Stéphanie; Missy, Pascale; Morin, Franck; Tran, Quan Hung; Deroy, Ángel Nazco; Milleron, B.; Blanché, Hélène; Zalcman, Gérard; Souquet, Pierre-Jean; », les membres de travail « non-fumeurs de l’IFCT du Groupe

doi:10.1016/j.rmr.2013.03.006

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…The BioCAST-IFCT1002 cohort dataset was employed, with the study design and overall results that have been previously reported [9,14]. The BioCAST study was designed to better define the clinical, pathological and molecular epidemiology of NSCLC in lifelong never-smokers in France.…”

Section: Populationmentioning

confidence: 99%

Association between lung cancer somatic mutations and occupational exposure in never-smokers

et al. 2017

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Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for and mutations, and alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of mutations (20% 44%, p=0.033), and a higher rate of mutations (18% 4%, p=0.084). alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced and mutation frequency.Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of mutations.

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Section: Populationmentioning

confidence: 99%

Association between lung cancer somatic mutations and occupational exposure in never-smokers

et al. 2017

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“…Participating centres were asked to include all consecutive newly diagnosed LCINS cases. IFCT research staff members were in charge of administrative management and quality assurance (in compliance with international research standards) [9].…”

Section: Populationmentioning

confidence: 99%

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

et al. 2015

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Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood.All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences.384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35%versus8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference):EGFRin 51%,ALKin 8%,KRASin 6%,HER2in 3%,BRAFin 3%,PI3KCAin less than 1%, and multiple in 2%.We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).

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“…Moreover, it is concerning that over 70% of participants reported having family or friends who smoke, yet only 13.7% advised them to quit. Given that second-hand smoke exposure is a well-established risk factor for LC, 28 encouraging smoking cessation through public health strategies becomes crucial for mitigating the substantial burden of LC in Saudi Arabia. 29 A London study revealed that former (14.5%) and never smokers (13%) believed LC screening was pointless if a person was still smoking.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Knowledge and Awareness of Lung Cancer and Screening in Jazan Region, Saudi Arabia

Madkhali,

Alhazmi,

Hakami

et al. 2023

JMDH

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Background Lung cancer (LC) is the most common cause of cancer-related deaths worldwide. With lung cancer often diagnosed at advanced stages, understanding the local population’s awareness levels is crucial for designing effective preventive strategies. By identifying gaps in knowledge, the research aims to inform targeted health education efforts, optimize resource allocation, influence policy development, and contribute to the limited body of research on lung cancer awareness in the region, ultimately fostering improved public health outcomes. Methods This was a cross-sectional observational study conducted in Jazan region, Saudi Arabia, from July 2022 to June 2023, 671 participants over 18 years old, encompassing both genders, were gsurveyed. Data was collected through a questionnaire covering sociodemographic characteristics and LC-related awareness. SPSS 23 was used for analysis. Factors associated with knowledge scores were explored using independent t -tests and ANOVA, with the Tukey post-hoc test identifying specific group differences. Results The study included 671 participants, most participants were between 18 and 35 years (73.5%), with 38.5% males and 61.5% females. Lung cancer (LC) awareness was high (95.1%), with 4.9% reporting a family history. Knowledge assessment revealed a mean score of 14.66, with 41.6% having low, 49.5% moderate, and 8.9% high knowledge levels. Correct responses were notable for recognizing LC as a common cancer, a leading cause of death, and associating smoking and shisha with risk. Symptoms were well identified. Screening awareness was at 63.5%, with 78.8% willing to undergo tests if at risk. Age, marital status, and occupation were associated with knowledge, while factors like gender, nationality, residency, education, income, and smoking status showed no significant associations. Conclusion The findings indicate that there are knowledge gaps related to LC and its screening in Jazan region in Saudi Arabia. Effective awareness programs targeting specific sociodemographic groups are needed to improve the early detection and outcomes.

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BioCAST : le Bio-observatoire national du cancer bronchiques chez les patients non fumeurs (IFCT1002)

Cited by 7 publications

References 32 publications

Association between lung cancer somatic mutations and occupational exposure in never-smokers

Association between lung cancer somatic mutations and occupational exposure in never-smokers

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

A Cross-Sectional Study on the Knowledge and Awareness of Lung Cancer and Screening in Jazan Region, Saudi Arabia

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