Biocatalysed synthesis of the enantiomers of the floral odorant Florhydral®

Enantioselective Copper‐Catalyzed Conjugate Addition of Trimethylaluminium to β,γ‐Unsaturated α‐Ketoesters

“…[29] The synthesis of this compound was already described in the literature but with poor yield or enantioselectivity. [30] With our strategy, we were able to obtain the (S)-florhydral (40) with very good yield, and high regio-and enantioselectivity (Scheme 3).…”

Homogeneous Asymmetric Catalysis in Fragrance Chemistry

“…Both transformations can be carried out without affecting the configuration of the stereogenic center. Oxidation of (R)- (2) or (S)-2, e.g., by pyridinium chlorochromate (PCC), smoothly affords (R)-3 or (S)-3 [28]; then Scheme 4 treatment of (R)-or (S)-3 with NH 2 OH in the presence of NaI and CH 3 CN according to [29] leads to (R)-4 or (S)-4, respectively.…”

Yeast‐Mediated Stereoselective Synthesis

“…Thus, yeast-mediated transformations have become a method of choice for producing fine chemicals, pharmaceuticals [24][25][26][27][28][29] as well as cosmetic ingredients (including flavor and fragrances) [30][31][32][33][34][35][36][37], and bioactive compounds [38][39][40][41] under mild conditions in high yields and excellent selectivity [42].…”