2021
DOI: 10.1021/acs.biomac.1c00240
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Biocatalysts Based on Peptide and Peptide Conjugate Nanostructures

Abstract: Peptides and their conjugates (to lipids, bulky N-terminals, or other groups) can self-assemble into nanostructures such as fibrils, nanotubes, coiled coil bundles, and micelles, and these can be used as platforms to present functional residues in order to catalyze a diversity of reactions. Peptide structures can be used to template catalytic sites inspired by those present in natural enzymes as well as simpler constructs using individual catalytic amino acids, especially proline and histidine. The literature … Show more

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Cited by 59 publications
(27 citation statements)
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References 208 publications
(445 reference statements)
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“…Supramolecular nanotubes formed by assembly of organic molecules such as lipids possess a one-dimensional cavity with a tunable diameter and chemically functionalizable surface. 1 Because of their high aspect ratios (length/diameter > 100–100 000), these cavities can be used as containers for the slow or sustained release of drugs, channels for the transport or separation of biomolecules, and templates for the production of conformationally controlled polymers and inorganic nanorods. 2 The confinement effect of the nanotube cavity is also useful for stabilizing proteins or accelerating their refolding.…”
Section: Introductionmentioning
confidence: 99%
“…Supramolecular nanotubes formed by assembly of organic molecules such as lipids possess a one-dimensional cavity with a tunable diameter and chemically functionalizable surface. 1 Because of their high aspect ratios (length/diameter > 100–100 000), these cavities can be used as containers for the slow or sustained release of drugs, channels for the transport or separation of biomolecules, and templates for the production of conformationally controlled polymers and inorganic nanorods. 2 The confinement effect of the nanotube cavity is also useful for stabilizing proteins or accelerating their refolding.…”
Section: Introductionmentioning
confidence: 99%
“…[140][141][142] It is important to note that apart from the above biochemical transformations, the peptide assemblies have been also exploited in promoting several other organocatalytic reactions such as Michael addition, Mannich reaction, etc. 143 Further, co-assembly between peptides and photosensitizers or photosensitizer-peptide conjugates has been shown to demonstrate artificial photosynthetic capabilities and various other phototherapeutic applications. [144][145][146][147]…”
Section: Peptide Based Self-assembly As Laccasementioning
confidence: 99%
“…68 Control of macromolecular topology with genetically encoded SpyTag-SpyCatcher chemistry 69,123,131 is also used to engineer protein hydrogels from tandem modular elastomeric and enzyme proteins that can find applications in tissue engineering, controlled drug release 132 and immobilisation of enzymes in multi-enzyme nanodevices. 129,[133][134][135][136] A single target enzyme molecule can be fused to both a SpyTag and a SpyCatcher and subsequently undergo cyclisation to form circular proteins, so-called SpyRings, through intramolecular formation of the original isopeptide bond, or This journal is © The Royal Society of Chemistry 2022 formation of enzyme aggregates through intermolecular coupling. 69 Circular proteins occur widely in nature, in plants animals and bacteria, and generally exhibit exceptional thermal stability and resistance to hydrolysis and proteolysis.…”
Section: Ligation Via Isopeptide Bonds In Tag/catcher Systemsmentioning
confidence: 99%