2024
DOI: 10.1002/adsc.202400169
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Biocatalytic Regio‐ and Enantiocomplementary Synthesis of Chiral Aryloxazolidinones

Xiao‐Ying Zhou,
Yuan‐Fei Wang,
Hong‐Kang Fu
et al.

Abstract: We described the protein engineering of the halohydrin dehalogenase HheG to enhance its R enantioselectivity for the synthesis of chiral 4‐aryloxazolidinones via α‐regioselective ring‐opening of aryl epoxides with cyanate. Additionally, we achieved the inversion of its regioselectivity and enantioselectivity, resulting in a HheG variant tailored for the synthesis of chiral 5‐aryloxazolidinones via β‐regioselective and S‐enantioselective ring‐opening of aryl epoxides with cyanate. Leveraging these engineered mu… Show more

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