Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion

Guo, Zehua; Wang, Tao; Rawal, Aditya; Hou, Jingwei; Cao, Zhengjun; Zhang, He; Xu, Jiangtao; Gu, Zi; Chen, Vicki; Liang, Kang

doi:10.1016/j.mattod.2019.04.022

Cited by 81 publications

(87 citation statements)

References 61 publications

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“…The porous framework of MOF significantly enhanced the biocatalytic activity of catalase, allowing O 2 bubbles to be produced at physiological conditions to propel the nanomotors. [93,94] Therefore, further multi-enzyme coencapsulation within MOFs is potent to exploit new nanomotors from diverse biochemical fuels. In addition, enzymes replacement therapies via constructing hybrid or artificial cells could be employed as organelle mimics with new biological properties or make great contribution to replacing the defective metabolic activities.…”

Section: Discussionmentioning

confidence: 99%

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Liang

2020

The Chemical Record

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Multi-enzyme cascade reactions are indispensable in biotechnology and many industrial (bio)chemical processes. However, most natural enzymes have poor stability and reusability, and tend to inactivate in toxic media or high temperature, which significantly limit their broader applications. Metal-organic frameworks (MOFs) are promising candidates for enzymes immobilization to produce nanocomposite structures that not only could shield the enzymes from harsh environments, but also facilitate selective diffusion of substrates and intermediates to the reactive site via their tailorable and ordered pore network. Multi-enzyme cascade reactions in MOFs have recently attracted considerable attention. This Personal Account discusses the different strategies for multi-enzyme-MOF interfaces and their cutting-edge applications from biosensing and catalytic nanomedicine to artificial/hybrid cells. At last, we provide a critical evaluation and future prospects to outline future research directions.

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Section: Discussionmentioning

confidence: 99%

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Liang

2020

The Chemical Record

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“…The intrinsic pores of MOFs act as channels to allow trafficking of small molecules, while the large guest molecules are prevented from leaching out. Commonly used ZIF-8 (zeolitic imidazolate frameworks 8) (including ZIF-L) and ZIF-90 frameworks are reported for encapsulating the desired guest biomolecules in aqueous solution under extremely mild synthetic conditions (70,73,75,76). Multiple enzymes can also be incorporated with one MOF particle in situ using similar preparation method (77).…”

Section: Exogenous Bioaugmentationmentioning

confidence: 99%

Nanobiohybrids: Materials approaches for bioaugmentation

et al. 2020

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Nanobiohybrids, synthesized by integrating functional nanomaterials with living systems, have emerged as an exciting branch of research at the interface of materials engineering and biological science. Nanobiohybrids use synthetic nanomaterials to impart organisms with emergent properties outside their scope of evolution. Consequently, they endow new or augmented properties that are either innate or exogenous, such as enhanced tolerance against stress, programmed metabolism and proliferation, artificial photosynthesis, or conductivity. Advances in new materials design and processing technologies made it possible to tailor the physicochemical properties of the nanomaterials coupled with the biological systems. To date, many different types of nanomaterials have been integrated with various biological systems from simple biomolecules to complex multicellular organisms. Here, we provide a critical overview of recent developments of nanobiohybrids that enable new or augmented biological functions that show promise in high-tech applications across many disciplines, including energy harvesting, biocatalysis, biosensing, medicine, and robotics.

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“…for their propulsion is highly desired and recommended . Unlike self‐propelled micromotors, light‐driven micromotors face a very challenging issue of achieving high velocities when moving. However, this can be accomplished using various combinations of materials with excellent catalytic performances .…”

Section: Introductionmentioning

confidence: 99%

Tailoring Metal/TiO₂ Interface to Influence Motion of Light‐Activated Janus Micromotors

Marić

Nasir

Webster

et al. 2020

Adv Funct Materials

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Catalytic light‐powered micromotors have become a major focus in current autonomous self‐propelled micromotors research. The attractiveness of such machines stems from the fact that these motors are “fuel‐free,” with their motion modulated by light irradiation. In order to study how different metals affect the velocities of metal/TiO2 micromachines in the presence of UV irradiation in pure water, Pt/TiO2, Cu/TiO2, Fe/TiO2, Ag/TiO2, and Au/TiO2 Janus micromotors are prepared. The metals have different chemical potentials and catalytic effects toward water splitting reaction, with both the effects expected to alter the photoelectrochemically‐induced reaction and propulsion rates. Analysis of structures, elemental compositions, motion patterns, velocities, and overall performances of different metals (Pt, Au, Ag, Fe, Cu) on TiO2 are observed by scanning electron microscopy, energy dispersive X‐ray spectroscopy, and optical microscopy. Electrochemical Tafel analysis is performed for the different metal/TiO2 structures and it is concluded that the effective velocity is a result of the synergistic effect of chemical potential and catalysis. It is found that the Pt/TiO2 Janus micromotors exhibit the fastest motion compared to the rest of the prepared materials. Furthermore, after exposure to UV light, every fabricated micromotor shows high possibility of forming assembled chains which influence their velocity.

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Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion

Cited by 81 publications

References 61 publications

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Nanobiohybrids: Materials approaches for bioaugmentation

Tailoring Metal/TiO₂ Interface to Influence Motion of Light‐Activated Janus Micromotors

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Biocatalytic self-propelled submarine-like metal-organic framework microparticles with pH-triggered buoyancy control for directional vertical motion

Cited by 81 publications

References 61 publications

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Multi‐enzyme Cascade Reactions in Metal‐organic Frameworks

Nanobiohybrids: Materials approaches for bioaugmentation

Tailoring Metal/TiO2 Interface to Influence Motion of Light‐Activated Janus Micromotors

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Tailoring Metal/TiO₂ Interface to Influence Motion of Light‐Activated Janus Micromotors