Biocatalytic Synthesis of Flavonoid Esters by Lipases and Their Biological Benefits

Araújo, Maria Elisa Melo Branco de; Franco, Yollanda Edwirges Moreira; Messias, Márcia Cristina Fernandes; Longato, Giovanna Barbarini; Pamphile, João Alencar; Carvalho, Patrícia de Oliveira

doi:10.1055/s-0042-118883

Cited by 56 publications

(57 citation statements)

References 125 publications

(187 reference statements)

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“…Enzymatic esterification is a well‐known reaction in biological synthesis, catalyzed majorly by lipases . Some members of the plant BAHD (benzylalcohol O ‐acetyltransferase [BEAT], deacetylvindoline 4‐ O ‐acetyltransferase [DAT], anthranilate N ‐hydroxycinnamoyl/benzoyltransferase [HCBT], anthocyanin O ‐hydroxycinnamoyltransferase [AHCT]) family also catalyze esterification reactions, while others catalyze amidification .…”

Section: Methodsmentioning

confidence: 99%

Biological Synthesis of Chiral p‐Coumaroyl Glycerol

Song

Sim

Lee

et al. 2019

Bulletin Korean Chem Soc

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Section: Methodsmentioning

confidence: 99%

Biological Synthesis of Chiral p‐Coumaroyl Glycerol

Song

Sim

Lee

et al. 2019

Bulletin Korean Chem Soc

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“…Moroever, the chemical methods for the flavonoid esters synthesis lead to the formation of side products and the simultaneous decomposition of the flavonoids. However, this type of biocatalytic synthesis of flavonoids with lipase is an interesting method to obtain active molecules with different polar substituents (de Araujo et al, 2017).…”

Section: Flavonoidsmentioning

confidence: 99%

Evaluation of the status quo of polyphenols analysis: Part I—phytochemistry, bioactivity, interactions, and industrial uses

Sanches-Silva

Reboredo‐Rodríguez

Süntar

et al. 2020

Comp Rev Food Sci Food Safe

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Phytochemicals, especially polyphenols, are gaining more attention from both the scientific community and food, pharmaceutical, and cosmetics industries due to their implications in human health. In this line, lately new applications have emerged, and of great importance is the selection of accurate and reliable analytical methods for better evaluation of the quality of the end-products, which depends on diverse process variables as well as on the matrices and on the physicochemical properties of different polyphenols. The first of a two-part review on polyphenols will address the phytochemistry and biological activities of different classes of polyphenols including flavonoids, lignans and flavanolignans, stilbenoids, tannins, curcuminoids, and coumarins. Moreover, the possible interactions of polyphenols and current and potential industrial applications of polyphenols are discussed. K E Y W O R D S bioactivity, flavonoid, industrial uses, phytochemistry, plant-based food, polyphenol, possible interactions How to cite this article: Silva AS, Reboredo-Rodríguez P, Süntar I, et al. Evaluation of the status quo of polyphenols analysis: part iphytochemistry, bioactivity, interactions and industrial uses.

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“…Over the past few years, structural modifications by employing enzymatic methodology have clearly become an important topic in carbohydrate chemistry. This has been described as the preferred method, possessing a short synthetic route, impressive selectivity, and environmental friendliness compared to the multistep chemical approaches (de Araújo et al, 2017;Dunbar et al, 2017). However, it is embarrassing that the documented commercially available enzymes (e.g., Novozym 435, lipozyme TLIM, and PSIM), which act as the central role in catalytic processes, usually suffer from high cost and unsatisfactory organic solvent tolerance (Gonçalves Filho et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Regioselective Decanoylation of Hyperoside Using Nanobiocatalyst of Fe3O4@PDA-Thermomyces lanuginosus Lipase: Insights of Kinetics and Stability Evaluation

Wang

Tian

et al. 2020

Front. Bioeng. Biotechnol.

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The immobilization of Thermomyces lanuginosus lipase on polydopamine-functionalized Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 @PDA-TLL) as a nanobiocatalyst was successfully performed for the first time, and the Fe 3 O 4 @PDA-TLL was used for regioselective acylation of natural hyperoside with vinyl decanoate. The effects of several crucial factors, such as the reaction solvent, substrate molar ratio, temperature, and immobilized enzyme dosage, were investigated. Under optimum conditions, the reaction rate, 6-regioselectivity, and maximum substrate conversion were as high as 12.6 mM/h, 100%, and 100%, respectively. An operational stability study demonstrated that the immobilized enzyme could maintain 90.1% of its initial maximum conversion even after reusing it five times. In addition, further investigations on the kinetic parameters, like V max , K m , V max /K m , and E a , also revealed that the biocompatible Fe 3 O 4 @PDA could act as an alternative carrier for the immobilization of different enzymes.

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Biocatalytic Synthesis of Flavonoid Esters by Lipases and Their Biological Benefits

Abstract: Several studies have described important biological activities of flavonoids such as coronary heart disease prevention, hepatoprotective, anti-inflammatory and anticancer activities, enzyme inhibition activity, and antibacterial, antifungal, and antiviral activities.

Cited by 56 publications

References 125 publications

Biological Synthesis of Chiral p‐Coumaroyl Glycerol

Biological Synthesis of Chiral p‐Coumaroyl Glycerol

Evaluation of the status quo of polyphenols analysis: Part I—phytochemistry, bioactivity, interactions, and industrial uses

Highly Efficient Regioselective Decanoylation of Hyperoside Using Nanobiocatalyst of Fe3O4@PDA-Thermomyces lanuginosus Lipase: Insights of Kinetics and Stability Evaluation

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