Biocatalyzed Production of Fine Chemicals

Hoyos, Pilar; Hernáiz, María J.; Alcántara, A.R.

doi:10.1016/b978-0-12-809633-8.09153-6

Cited by 9 publications

(6 citation statements)

References 168 publications

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“…When considering industrial applications, whole-cell and isolated enzymes approaches must be put into balance (Hoyos et al, 2017). The whole-cell approach is attractive for some enzymes like ADHs that require in situ supply and regeneration of a cofactor (Romano et al, 2012;Sheldon and Brady, 2019).…”

Section: Whole-cell Catalysismentioning

confidence: 99%

Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

Ribeaucourt

Bissaro

Lambert

et al. 2022

Biotechnology Advances

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Section: Whole-cell Catalysismentioning

confidence: 99%

Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

Ribeaucourt

Bissaro

Lambert

et al. 2022

Biotechnology Advances

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“…Biocatalysts has proven to be an excellent and greener complement for classical organic synthesis, as the employ of biocatalysts (either native, chemically, or genetically modified) allows very clean and selective procedures [97][98][99][100][101][102][103][104][105][106]. Regarding the biocatalytic synthesis of 1,3-diketones, a straightforward methodology was initially reported in 2010 by Müller and coworkers [107] by using a recombinant enzyme (YpYerE, a thiamine diphosphate (ThDP)-dependent aldolase from Yersinia pseudotuberculosis O:VI).…”

Section: Biocatalytic Synthesis Of 13-diketonesmentioning

confidence: 99%

Recent Developments in the Synthesis of β-Diketones

Gonzalo

Alcántara

2021

Pharmaceuticals

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Apart from being one of the most important intermediates in chemical synthesis, broadly used in the formation of C–C bonds among other processes, the β-dicarbonyl structure is present in a huge number of biologically and pharmaceutically active compounds. In fact, mainly derived from the well-known antioxidant capability associated with the corresponding enol tautomer, β-diketones are valuable compounds in the treatment of many pathological disorders, such as cardiovascular and liver diseases, hypertension, obesity, diabetes, neurological disorders, inflammation, skin diseases, fibrosis, or arthritis; therefore, the synthesis of these structures is an area of overwhelming interest for organic chemists. This paper is devoted to the advances achieved in the last ten years for the preparation of 1,3-diketones, using different chemical (Claisen, hydration of alkynones, decarboxylative coupling) or catalytic (biocatalysis, organocatalytic, metal-based catalysis) methodologies: Additionally, the preparation of branched β-dicarbonyl compounds by means of α-functionalization of non-substituted 1,3-diketones are also discussed.

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“…Enzymes are undoubtedly the most efficient catalysts ever known, as they can proficiently perform their catalytic function under mild conditions, in a very specific (modifying only the target physiological substrate) and selective (producing only the target product) manner [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. As a result, they are extremely useful in very diverse areas of application.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, some of these features that are necessary for microorganisms to respond to changes in the environment do not fit the requirements for large-scale industrial applications [16]. Nevertheless, enzymes have found application in many industrial processes, from fine chemistry [1,12,13] to energy production [17][18][19][20][21] or food technology [22][23][24][25]. When employed as industrial biocatalysts, the desired enzymatic capability may not be always the same; for instance, chemo-and regio-selectivity will be always necessary, while enzyme stereoselectivity would be demanded in the resolution of racemic mixtures or in the desymmetrization of prochiral compounds.…”

Section: Introductionmentioning

confidence: 99%

Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

et al. 2019

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Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that is very useful in many areas, including as a macromolecular carrier for drug delivery and other biomedical applications. In particular, it has been widely used for chemical engineering of enzymes, with the aim of designing better biocatalysts that possess improved catalytic properties, making them more stable and/or active for different catalytic reactions. This polymer possesses a very flexible hydrophilic structure, which becomes inert after chemical reduction; therefore, dexOx comes to be highly versatile in a biocatalyst design. This paper presents an overview of the multiple applications of dexOx in applied biocatalysis, e.g., to modulate the adsorption of biomolecules on carrier surfaces in affinity chromatography and biosensors design, to serve as a spacer arm between a ligand and the support in biomacromolecule immobilization procedures or to generate artificial microenvironments around the enzyme molecules or to stabilize multimeric enzymes by intersubunit crosslinking, among many other applications.

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Biocatalyzed Production of Fine Chemicals

Cited by 9 publications

References 168 publications

Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

Biocatalytic oxidation of fatty alcohols into aldehydes for the flavors and fragrances industry

Recent Developments in the Synthesis of β-Diketones

Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

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