Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao, Chengwei; Liu, Weiye; Zhu, Min; Wu, Chengtie; Zhu, Yufang

doi:10.1016/j.bioactmat.2022.02.010

Cited by 90 publications

(56 citation statements)

References 122 publications

(267 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concentration, quantity of the binding material drop, and viscosity of the printed scaffold are all influenced by the density of the platform or powder bed after the powder has been distributed, particle size, surface finish, and morphology, and the surface tension of the powder and the binder in 3DP [61]. The parameters given above must be substantially changed when using 3DP to create a structure out of a unique bioceramic composition.…”

Section: Methodsmentioning

confidence: 99%

“…Tissue Engineering of Biomaterial Scaffold. Tissue engineering is a technique that involves using donor healthy tissue and biomaterial scaffold techniques to produce bioartificial tissues in vitro and changing cell development and function in vivo [9][10][11]. To support effective binding, motility, and production of intrinsic extracellular matrix (ECM) components by cells, biomaterials for biomedical applications must have controlled surface shape, porosity, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Survey on Additively Manufactured Nanocomposite Biomaterial for Orthopaedic Applications

Gowtham¹,

Kumar

Devi

et al. 2022

Journal of Nanomaterials

View full text Add to dashboard Cite

The sturdy demands in orthopaedics are not yet fulfilled, in both bone replacement and joint substitution and also in other repairs of bone defects. Metals are used for bone repair and replacement for a long period of time instead of biomaterial. Most of the countries are still now practising bone replacement with metals like titanium and stainless steel only due to the lag of technology advancement. A lot of research and development paves the way to composite biomaterial, as it is evolving in the domain of treatment of orthopaedics. There was massive research undergoing in the biomaterial field recently, and various methods of fabrication have been tested and implemented. Nanocomposites provide a higher surface-to-volume ratio, surface chemistry and nanoscale reinforcement, flexible production techniques, good corrosion and erosion resistance, and cheaper costs. The nanocomposite biomaterials were intended for biomedical purposes. Because of the intricacy of biological structures (tissue or organ) and additive manufacturing techniques for tissue engineering, scaffolding has wide scope for instant remedies in bone implant. The design restrictions and physical attributes of fast prototyping structures are then evaluated in terms of input factors like design elements, material choices, and additive manufacturing processing parameters. As a result of this survey, the needs and application importance of additively manufactured implants for the regeneration of various biomaterial types as well as the attempts undertaken to mitigate their medical impairment are suggested.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Survey on Additively Manufactured Nanocomposite Biomaterial for Orthopaedic Applications

Gowtham¹,

Kumar

Devi

et al. 2022

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Additional properties, such as an antibacterial effect, are also addressed in order to prevent the risk of infection that can occur after implantation of a bone substitute. For this application, silver and copper are the most investigated elements to dope HA (Zhao et al, 2022).…”

Section: Principles Of Ionic Substitutionsmentioning

confidence: 99%

Calcium phosphate bioceramics: From cell behavior to chemical-physical properties

Magnaudeix

2022

Front. Biomater. Sci.

View full text Add to dashboard Cite

Calcium phosphate ceramics, including hydroxyapatite (HA), have been used as bone substitutes for more than 40 years. Their chemical composition, close to that of the bone mineral, confers them good biological and physical properties. However, they are not sufficient to meet all the needs in bone regenerative medicine, such as in the context of critical bone lesions. Therefore, it is essential to improve their biological performances in order to extend their application domains. In this aim, three approaches are mainly followed on the assumption that the biological response can be tuned by modifications of the chemical physical properties of the ceramic: 1) Incorporation of specific chemical species into the calcium phosphate crystalline lattice of chemical elements to stimulate bone repair. 2) Modulation of the bioceramic architecture to optimize the cellular responses at the interface. 3) Functionalization of the bioceramic surface with bioactive molecules. These approaches are supposed to act on separate parameters but, as they are implemented during different steps of the ceramic processing route, they cannot be considered as exclusive. They will ineluctably induces changes of several other physical chemical properties of the final ceramic that may also affect the biological response. Using examples of recent works from our laboratory, the present paper aims to describe how biology can be affected by the bioceramics modifications according to each one of these approaches. It shows that linking biological and chemical physical data in a rational way makes it possible to identify pertinent parameters and related processing levers to target a desired biological response and then more precisely tune the biological performance of ceramic biomaterials. This highlights the importance of integrating the biological evaluation into the heart of the processes used to manufacture optimized biomaterials.

show abstract

“…CS-based hydrogels have the advantages of simple preparation, low cost, high conductivity, and good biocompatibility [ 16 ]. At present, CS-based hydrogels have been dedicated to improving different applications such as BTE, in situ tumor therapy, and wound dressings [ 14 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability

Zhang

Yang

et al. 2022

Biomolecules

View full text Add to dashboard Cite

In recent years, multifunctional hydrogels have received a great deal of attention because they are biocompatible and can mimic the extracellular matrix. Herein, we prepared hydrogels of biocompatible cross-linked networks with photothermal properties. In this study, a chitosan/polyaniline/laponite (COL) hydrogel with photothermal conversion capability was designed. Polyaniline was firstly grafted onto chitosan and its solution was mixed with oxidized dextran, which was then cross-linked into a hydrogel via a Schiff base reaction. Furthermore, an aluminosilicate clay material, laponite (LAP), was incorporated into the hydrogel. The swelling ratio of the COL hydrogel in various solutions was greater than 580%, and it showed good degradation ability (the mass–loss ratio was over 45% after 28 days). This composite hydrogel was demonstrated to have good photothermal conversion properties and biocompatibility at both the cell (cell viability was over 97%) and animal levels. The COL hydrogel showed a photothermal conversion efficiency of 23.7% under the irradiation of a near-infrared laser. Coupled with the osteogenic differentiation-inducing potential of LAP, the COL hydrogel has the potential to kill tumors via hyperthermia or serve as scaffolds for bone tissue regeneration.

show abstract

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Cited by 90 publications

References 122 publications

A Survey on Additively Manufactured Nanocomposite Biomaterial for Orthopaedic Applications

A Survey on Additively Manufactured Nanocomposite Biomaterial for Orthopaedic Applications

Calcium phosphate bioceramics: From cell behavior to chemical-physical properties

Design of Biocompatible Chitosan/Polyaniline/Laponite Hydrogel with Photothermal Conversion Capability

Contact Info

Product

Resources

About