The aim of this study was to evaluate the dependence of sintering conditions on mechanical properties and microstructure of zirconia stabilized by yttria. Commercial blocks of pre-sintered of zirconia stabilized (DeguDent Dentsply, Germany-Cercon) were investigated in this study. The blocks belonging to group 1 were sintered under the recommended conditions by the manufacturer (1350°C for 6 hours). The blocks of group 2 were sintered under 1500°C for 6 hours. The blocks of group 3 were sintered under 1350 C for 14.5 hours. The results indicated that the sintering conditions influenced the mechanical properties and microstructure of zirconia. The three sintering conditions analyzed in this study produces zirconia bodies with properties adequate to be used in clinical function. However, the decisive factor for change in the sintering conditions should be the cost/benefit during the prosthetical process and longevity of clinical material to perform its function in the oral cavity.