Bioceramics for skeletal bone regeneration

Hardystonite‐Coated Poly(l‐lactide) Nanofibrous Scaffold and Efficient Osteogenic Differentiation of Adipose‐Derived Mesenchymal Stem Cells

“…During the development of bone and connective tissues, Si plays an essential role by increasing the mRNA expression of key osteoblastic and collagen I genes (24). However, the high degradation rate of CaO-SiO 2 three-dimensional (3D) scaffolds would deteriorate cell functions by generating an alkaline microenvironment upon the release of excessive dissolution products and result in scaffold collapse prior to generation of satisfactory quantity of bone ECM (18). However, the high degradation rate of CaO-SiO 2 three-dimensional (3D) scaffolds would deteriorate cell functions by generating an alkaline microenvironment upon the release of excessive dissolution products and result in scaffold collapse prior to generation of satisfactory quantity of bone ECM (18).…”

“…Ca-Si based materials are another class of bioactive ceramics with potential application in bone regeneration. On the other hand, Zn positively influences osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone DNA content and additionally modulates osteoclast function (18). On the other hand, Zn positively influences osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone DNA content and additionally modulates osteoclast function (18).…”

“…Since hydroxyapatite (HAp) is the major inorganic bone constituent, HAp and related Ca-P compounds such as aand b-tricalcium phosphate (TCP) are the most widely investigated ceramics for fabrication of bone tissue scaffolds (18). HAp mainly consists of the predominant bone mineral elements of calcium and phosphate and lacks other vital trace elements (19).…”

“…Ca-Si based materials are another class of bioactive ceramics with potential application in bone regeneration. However, the high degradation rate of CaO-SiO 2 three-dimensional (3D) scaffolds would deteriorate cell functions by generating an alkaline microenvironment upon the release of excessive dissolution products and result in scaffold collapse prior to generation of satisfactory quantity of bone ECM (18). On the other hand, Zn positively influences osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone DNA content and additionally modulates osteoclast function (18).…”

“…However, the high degradation rate of CaO-SiO 2 three-dimensional (3D) scaffolds would deteriorate cell functions by generating an alkaline microenvironment upon the release of excessive dissolution products and result in scaffold collapse prior to generation of satisfactory quantity of bone ECM (18). On the other hand, Zn positively influences osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone DNA content and additionally modulates osteoclast function (18). Incorporation of Zn into Ca-Si based ceramics and synthesis of hardystonite (HS, Ca 2 ZnSi 2 O 7 ) would compensate the high dissolution rate of Ca-Si and subsequently improve its mechanical properties (25,26).…”