Bioceramics in ophthalmology

Baino, Francesco; Brovarone, Chiara Vitale

doi:10.1016/j.actbio.2014.05.017

Cited by 45 publications

(24 citation statements)

References 236 publications

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“…Zirconia substrate has been coated with melted BG powder produced by conventional or sol-gel derived methods previously 19,22,26,27) . Dip coating of zirconia in the sol-gel solution followed by sintering was reported by Matsuda et al 28) and fabrication of the 45S5 BG coating by dip coating method in the sol-gel solution and its apatite formation ability in the simulated body fluid (SBF) on Mg substrates are reported previously 29,30) .…”

Section: Introductionmentioning

confidence: 99%

Bioactive glass coating on zirconia by vacuum sol-dipping method

et al. 2019

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In order to the preparation of biodegradable, bioactive and strongly adhered coating layer to the bioinert zirconia substrate, a bioactive glass (BG) was successfully coated on the zirconia plates. To achieve this goal, the zirconia plates dipped into the 45S5 BG sol in the vacuum chamber (vacuum sol-dipping method) followed by sintering to fabricate a strongly adhered BG coating on the zirconia plates. The parameters such as surface morphology and BG coating coverage ability on the zirconia plates have been assessed before and after coating with 45S5 BG. Phase structure of the BG coating based on the X-ray diffraction (XRD) result could be indexed as Na4Ca4(Si6O18). The interfacial adhesive strength between the zirconia substrate and BG coating layer was higher than the measured adhesive strength (55±7 MPa). The viability results approved the satisfying conclusion for the offered coating method on the zirconia substrates.

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Section: Introductionmentioning

confidence: 99%

Bioactive glass coating on zirconia by vacuum sol-dipping method

et al. 2019

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“…To date, β-Ca 2 SiO 4 scaffolds were prepared by conventional methods such as polyurethane foam templating [18] and porogen templating [30], which were not easy to control porous scaffolds with well pore interconnection, proper pore size, or high porosity [31,32]. 3D printing technique can control the architectures of porous scaffolds via computer-assisted design or computer-aided manufacturing.…”

Section: Introductionmentioning

confidence: 99%

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Liu

et al. 2018

Science and Technology of Advanced Materials

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Silicate bioceramic scaffolds are of great interest in bone tissue engineering, but the fabrication of silicate bioceramic scaffolds with complex geometries is still challenging. In this study, three-dimensional (3D) porous β-Ca2SiO4 scaffolds have been successfully fabricated from preceramic resin loaded with CaCO3 active filler by 3D printing. The fabricated β-Ca2SiO4 scaffolds had uniform interconnected macropores (ca. 400 μm), high porosity (>78%), enhanced mechanical strength (ca. 5.2 MPa), and excellent apatite mineralization ability. Importantly, the results showed that the increase of sintering temperature significantly enhanced the compressive strength and the scaffolds sintered at higher sintering temperature stimulated the adhesion, proliferation, alkaline phosphatase activity, and osteogenic-related gene expression of rat bone mesenchymal stem cells. Therefore, the 3D printed β-Ca2SiO4 scaffolds derived from preceramic resin and CaCO3 active fillers would be promising candidates for bone tissue engineering.

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“…[5][6][7][8][9][10] However, it is thought to be a tough challenge to regenerate the entire pulp and dentin in situ due to the anatomical arrangement of the pulp chamber, which is encased within the dentin and mainly relies on one apical foramen to allow angiogenesis for the engineered tissue. 9,[12][13][14][15][16][17] Therefore, it is of great necessity to develop a suitable and injectable scaffold that can penetrate the entire root canal space 1,4,5,8,[18][19][20][21][22] and is also suitable for clinical application. Moreover, pulp is a type of so tissue, while the surrounding dentin is relatively hard.…”

Section: Introductionmentioning

confidence: 99%

Regeneration of dentin–pulp-like tissue using an injectable tissue engineering technique

Tan

Wang

Yin³

et al. 2015

RSC Adv.

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An injectable tissue engineering method was developed for dentin-pulp complex regeneration using an injectable scaffold, crosslinked hyaluronic acid gel (HAG). A cell-scaffold composite composed of HAG, tooth bud-derived dental mesenchymal cells (DMCs), and transforming growth factor-b1 (TGF-b1) was prepared and injected subcutaneously into nude mice. Moreover, b-tricalcium phosphate (b-TCP) and polyglycolic acid (PGA) were chosen as control scaffolds for dentin-pulp regeneration. The suitability of injectable HAG for dentin-pulp complex engineering was further demonstrated in empty tooth slices and the pulp chambers of mini pigs. Histological and immunohistochemical staining was carried out to identify the distinctive tubular dentin and pulp structure, which was further confirmed by the detection of several dentinogenesis-related genes, DSPP, DMP-1, MEPE, and BSP. It was found that a recognizable dentin-pulp-like tissue with a typical well-organized dentinal tubular structure, columnar odontoblastlike cells, was successfully engineered using the injectable HAG scaffold within the subcutaneous area of nude mice, according to histological staining. High expression of the genes DSPP, DMP-1, MEPE and BSP in the above neo-tissue as well as positive immunohistochemical staining for dentin sialoprotein (DSP) confirmed the dentinal characteristics. No typical dentin-or pulp-like tissue was formed when PGA or b-TCP were used as scaffolds. The efficacy of this method was further demonstrated in empty tooth slices and pulp chambers of mini pigs that had been pretreated by the removal of total pulp and partial dentin. Through the successful delivery of DMCs and TGF-b1 by the injectable HAG scaffold, the destroyed dentin was vividly repaired along with the formation of pulp-like tissue. Hence the current strategy to engineer dentin-pulp complex can overcome the difficulty of specific anatomical arrangement of pulp and dentin with minimal invasion, finally leading to regained vitality, which is difficult to realize by the current clinical treatments.

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Bioceramics in ophthalmology

Cited by 45 publications

References 236 publications

Bioactive glass coating on zirconia by vacuum sol-dipping method

Bioactive glass coating on zirconia by vacuum sol-dipping method

3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties

Regeneration of dentin–pulp-like tissue using an injectable tissue engineering technique

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Bioceramics in ophthalmology

Cited by 45 publications

References 236 publications

Bioactive glass coating on zirconia by vacuum sol-dipping method

Bioactive glass coating on zirconia by vacuum sol-dipping method

3D printed porous β-Ca2SiO4scaffolds derived from preceramic resin and their physicochemical and biological properties

Regeneration of dentin–pulp-like tissue using an injectable tissue engineering technique

Contact Info

Product

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3D printed porous β-Ca₂SiO₄scaffolds derived from preceramic resin and their physicochemical and biological properties